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Menetrier's disease (protein-losing gastropathy) in a child with acute lymphoblastic leukemia.
Int J Pediatr Adolesc Med 2019; 6(1):38-40IJ

Abstract

A 3-year-old boy with high-risk precursor-B ALL presented with abdominal pain, vomiting, and hypoalbuminemia just before his second scheduled course of high-dose methotrexate in interim maintenance. Examination was significant for epigastric tenderness and periorbital edema. Abdominal imaging revealed a circumferential thickening of the stomach with an increased mucosal enhancement and a mild circumferential thickening of segments of small bowel loops. Cytomegalovirus (CMV) of the patient, determined by PCR, in blood was positive with a low titer and was subsequently negative. Upper endoscopy revealed hypertrophic rugae and folds in the stomach and duodenum, and biopsy showed giant gastric folds and foveolar hyperplasia but was negative for CMV. He received supportive care and a 2-week course of ganciclovir and Cytogam with clinical improvement. We report a case of Menetrier's disease (Protein-losing gastropathy), which was diagnosed in a child with acute leukemia. Menetrier's disease should be considered in any patient with symptoms referable to the gastrointestinal tract and thickened stomach and bowel loops detected by radiologic imaging.

Authors+Show Affiliations

Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada. Mansoura University Children Hospital, Pediatric Department, Faculty of Medicine, Mansoura University, Al-Mansoura, 35516, Egypt.Department Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.Department Paediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.Division of Haematology/Oncology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8, Canada.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31304227

Citation

Fouda, Ashraf, et al. "Menetrier's Disease (protein-losing Gastropathy) in a Child With Acute Lymphoblastic Leukemia." International Journal of Pediatrics & Adolescent Medicine, vol. 6, no. 1, 2019, pp. 38-40.
Fouda A, Kamath B, Chung C, et al. Menetrier's disease (protein-losing gastropathy) in a child with acute lymphoblastic leukemia. Int J Pediatr Adolesc Med. 2019;6(1):38-40.
Fouda, A., Kamath, B., Chung, C., & Punnett, A. (2019). Menetrier's disease (protein-losing gastropathy) in a child with acute lymphoblastic leukemia. International Journal of Pediatrics & Adolescent Medicine, 6(1), pp. 38-40. doi:10.1016/j.ijpam.2019.01.002.
Fouda A, et al. Menetrier's Disease (protein-losing Gastropathy) in a Child With Acute Lymphoblastic Leukemia. Int J Pediatr Adolesc Med. 2019;6(1):38-40. PubMed PMID: 31304227.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Menetrier's disease (protein-losing gastropathy) in a child with acute lymphoblastic leukemia. AU - Fouda,Ashraf, AU - Kamath,Binita, AU - Chung,Catherine, AU - Punnett,Angela, Y1 - 2019/01/07/ PY - 2018/08/29/received PY - 2018/11/20/revised PY - 2019/01/06/accepted PY - 2019/7/16/entrez PY - 2019/7/16/pubmed PY - 2019/7/16/medline KW - Acute lymphoblastic leukemia KW - Menetrier's disease KW - Protein-losing gastropathy SP - 38 EP - 40 JF - International journal of pediatrics & adolescent medicine JO - Int J Pediatr Adolesc Med VL - 6 IS - 1 N2 - A 3-year-old boy with high-risk precursor-B ALL presented with abdominal pain, vomiting, and hypoalbuminemia just before his second scheduled course of high-dose methotrexate in interim maintenance. Examination was significant for epigastric tenderness and periorbital edema. Abdominal imaging revealed a circumferential thickening of the stomach with an increased mucosal enhancement and a mild circumferential thickening of segments of small bowel loops. Cytomegalovirus (CMV) of the patient, determined by PCR, in blood was positive with a low titer and was subsequently negative. Upper endoscopy revealed hypertrophic rugae and folds in the stomach and duodenum, and biopsy showed giant gastric folds and foveolar hyperplasia but was negative for CMV. He received supportive care and a 2-week course of ganciclovir and Cytogam with clinical improvement. We report a case of Menetrier's disease (Protein-losing gastropathy), which was diagnosed in a child with acute leukemia. Menetrier's disease should be considered in any patient with symptoms referable to the gastrointestinal tract and thickened stomach and bowel loops detected by radiologic imaging. SN - 2352-6467 UR - https://www.unboundmedicine.com/medline/citation/31304227/Menetrier's_disease_(protein-losing_gastropathy)_in_a_child_with_acute_lymphoblastic_leukemia L2 - https://linkinghub.elsevier.com/retrieve/pii/S2352-6467(18)30150-9 DB - PRIME DP - Unbound Medicine ER -