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Association between ambient particulate matter concentration and fetal growth restriction stratified by maternal employment.
BMC Pregnancy Childbirth. 2019 Jul 15; 19(1):246.BP

Abstract

BACKGROUND

Fetal growth has been known to be associated with particulate matter (PM) air pollution during gestation. Given that regular working may deviate outdoor air pollution exposure, the association between air pollution and fetal growth restriction can be different across maternal working status. This study was to assess possible effect modification by maternal employment in the association between exposure to PM during pregnancy and fetal growth restriction.

METHODS

Using hourly PM less than or equal to 10 and 2.5 μm in diameter (PM10 and PM2.5) regulatory monitoring data for 2001-2012 and 2008-2012, respectively, and birth certificate data for 2002-2012, we computed maternal exposures with district-level averages of PM10 and PM2.5 during one year before birth, entire pregnancy, and the 1st, 2nd and 3rd trimesters. The outcomes of fetal growth restriction were assessed by small for gestational age (SGA, weighted <10th percentile in the same gestational age) as well as low birth weight (LBW, < 2.5 kg) at term. We performed logistic regression to examine the association between PM and each of fetal growth restriction outcomes adjusting for individual risk factors. For effect modification by maternal employment, we estimated adjusted odds ratio (OR) of SGA or LBW for interquartile (IQR) increases in PM10 or PM2.5 stratified by employed and non-employed mothers. We also computed relative excess risk due to interaction (RERI) to investigate additive interaction.

RESULTS

Among 824,011 singleton term births, 34.0% (279,856) were employed and 66.0% (544,155) were non-employed mothers. Proportions of LBW were 1.5% in employed and 1.6% in non-employed (P < 0.001). SGA occurred in 12.7% of employed and 12.8% of non- employed (P = 0.124) mothers. For non-employed mothers, we observed increased odds of SGA per IQR increase in PM10 for one year before birth (OR = 1.02, 95% confidence intervals (CI): 1.00-1.04, P = 0.028). ORs of SGA for full pregnancy period and the 3rd trimester were also positive but did not reach statistical significance. We did not observe positive association for PM2.5. RERI was not significant both for PM10 and PM2.5.

CONCLUSIONS

We did not observe evidence of effect modification by maternal employment in the association between ambient PM and fetal growth restriction. Future studies using more refined exposure measures should confirm this finding.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, CHA University School of Medicine, Gyeonggi-do, 11160, Korea. Department of Epidemiology, Graduate School of Public Health, Brown University, Providence, RI, 02903, USA.Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, IL, 60607, USA.Department of Statistics, Seoul National University, Seoul, 08826, South Korea.Department of Statistics, Seoul National University, Seoul, 08826, South Korea.Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Korea. sykim@ncc.re.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31307418

Citation

Choe, Seung-Ah, et al. "Association Between Ambient Particulate Matter Concentration and Fetal Growth Restriction Stratified By Maternal Employment." BMC Pregnancy and Childbirth, vol. 19, no. 1, 2019, p. 246.
Choe SA, Jang J, Kim MJ, et al. Association between ambient particulate matter concentration and fetal growth restriction stratified by maternal employment. BMC Pregnancy Childbirth. 2019;19(1):246.
Choe, S. A., Jang, J., Kim, M. J., Jun, Y. B., & Kim, S. Y. (2019). Association between ambient particulate matter concentration and fetal growth restriction stratified by maternal employment. BMC Pregnancy and Childbirth, 19(1), 246. https://doi.org/10.1186/s12884-019-2401-9
Choe SA, et al. Association Between Ambient Particulate Matter Concentration and Fetal Growth Restriction Stratified By Maternal Employment. BMC Pregnancy Childbirth. 2019 Jul 15;19(1):246. PubMed PMID: 31307418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between ambient particulate matter concentration and fetal growth restriction stratified by maternal employment. AU - Choe,Seung-Ah, AU - Jang,Jiyeong, AU - Kim,Min Jung, AU - Jun,Yoon-Bae, AU - Kim,Sun-Young, Y1 - 2019/07/15/ PY - 2019/01/03/received PY - 2019/07/04/accepted PY - 2019/7/17/entrez PY - 2019/7/17/pubmed PY - 2020/1/31/medline KW - Air pollution KW - Employment KW - Low birth weight KW - Particulate matter KW - Small for gestational age SP - 246 EP - 246 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 19 IS - 1 N2 - BACKGROUND: Fetal growth has been known to be associated with particulate matter (PM) air pollution during gestation. Given that regular working may deviate outdoor air pollution exposure, the association between air pollution and fetal growth restriction can be different across maternal working status. This study was to assess possible effect modification by maternal employment in the association between exposure to PM during pregnancy and fetal growth restriction. METHODS: Using hourly PM less than or equal to 10 and 2.5 μm in diameter (PM10 and PM2.5) regulatory monitoring data for 2001-2012 and 2008-2012, respectively, and birth certificate data for 2002-2012, we computed maternal exposures with district-level averages of PM10 and PM2.5 during one year before birth, entire pregnancy, and the 1st, 2nd and 3rd trimesters. The outcomes of fetal growth restriction were assessed by small for gestational age (SGA, weighted <10th percentile in the same gestational age) as well as low birth weight (LBW, < 2.5 kg) at term. We performed logistic regression to examine the association between PM and each of fetal growth restriction outcomes adjusting for individual risk factors. For effect modification by maternal employment, we estimated adjusted odds ratio (OR) of SGA or LBW for interquartile (IQR) increases in PM10 or PM2.5 stratified by employed and non-employed mothers. We also computed relative excess risk due to interaction (RERI) to investigate additive interaction. RESULTS: Among 824,011 singleton term births, 34.0% (279,856) were employed and 66.0% (544,155) were non-employed mothers. Proportions of LBW were 1.5% in employed and 1.6% in non-employed (P < 0.001). SGA occurred in 12.7% of employed and 12.8% of non- employed (P = 0.124) mothers. For non-employed mothers, we observed increased odds of SGA per IQR increase in PM10 for one year before birth (OR = 1.02, 95% confidence intervals (CI): 1.00-1.04, P = 0.028). ORs of SGA for full pregnancy period and the 3rd trimester were also positive but did not reach statistical significance. We did not observe positive association for PM2.5. RERI was not significant both for PM10 and PM2.5. CONCLUSIONS: We did not observe evidence of effect modification by maternal employment in the association between ambient PM and fetal growth restriction. Future studies using more refined exposure measures should confirm this finding. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/31307418/Association_between_ambient_particulate_matter_concentration_and_fetal_growth_restriction_stratified_by_maternal_employment_ L2 - https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-019-2401-9 DB - PRIME DP - Unbound Medicine ER -