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Ameliorative effects of ginseng and ginsenosides on rheumatic diseases.
J Ginseng Res 2019; 43(3):335-341JG

Abstract

Background

Inflammation is a host-defensive innate immune response to protect the body from pathogenic agents and danger signals induced by cellular changes. Although inflammation is a host-defense mechanism, chronic inflammation is considered a major risk factor for the development of a variety of inflammatory autoimmune diseases, such as rheumatic diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases that primarily affect connective tissues and are characterized by severe chronic inflammation and degeneration of connective tissues. Ginseng and its bioactive ingredients, genocides, have been demonstrated to have antiinflammatory activity and pharmacological effects on various rheumatic diseases by inhibiting the expression and production of inflammatory mediators.

Methods

Literature in this review was searched in a PubMed site of National Center for Biotechnology Information.

Results

The studies reporting the preventive and therapeutic effects of ginseng and ginsenosides on the pathogenesis of rheumatic diseases were discussed and summarized.

Conclusion

Ginseng and ginsenosides play an ameliorative role on rheumatic diseases, and this review provides new insights into ginseng and ginsenosides as promising agents to prevent and treat rheumatic diseases.

Authors+Show Affiliations

Department of Pharmaceutical Engineering, Cheongju University, Cheongju, Republic of Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31308803

Citation

Yi, Young-Su. "Ameliorative Effects of Ginseng and Ginsenosides On Rheumatic Diseases." Journal of Ginseng Research, vol. 43, no. 3, 2019, pp. 335-341.
Yi YS. Ameliorative effects of ginseng and ginsenosides on rheumatic diseases. J Ginseng Res. 2019;43(3):335-341.
Yi, Y. S. (2019). Ameliorative effects of ginseng and ginsenosides on rheumatic diseases. Journal of Ginseng Research, 43(3), pp. 335-341. doi:10.1016/j.jgr.2018.04.004.
Yi YS. Ameliorative Effects of Ginseng and Ginsenosides On Rheumatic Diseases. J Ginseng Res. 2019;43(3):335-341. PubMed PMID: 31308803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effects of ginseng and ginsenosides on rheumatic diseases. A1 - Yi,Young-Su, Y1 - 2018/04/28/ PY - 2018/03/06/received PY - 2018/04/23/accepted PY - 2019/7/17/entrez PY - 2019/7/17/pubmed PY - 2019/7/17/medline KW - ACAN, Aggrecan KW - ACLT, Anterior cruciate ligament transection KW - BMP, Bone morphogenetic protein KW - CIA, Collagen-induced arthritic KW - CK, Compound K KW - COL, Collagen KW - DAMP, Danger-associated molecular pattern KW - Ginseng KW - Ginsenosides KW - Inflammation KW - LTMMR, Ligament transection and medial meniscus resection KW - Macrophages KW - OA, Osteoarthritis KW - PAMP, Pathogen-associated molecular pattern KW - PPD, Protopanaxadiol KW - PPT, Protopanaxatriol KW - PRR, Pattern-recognition receptor KW - RA, Rheumatoid arthritis KW - RNAKL, Receptor activator of NF-κB ligand KW - Rheumatic diseases KW - SLE, Systemic lupus erythematosus SP - 335 EP - 341 JF - Journal of ginseng research JO - J Ginseng Res VL - 43 IS - 3 N2 - Background: Inflammation is a host-defensive innate immune response to protect the body from pathogenic agents and danger signals induced by cellular changes. Although inflammation is a host-defense mechanism, chronic inflammation is considered a major risk factor for the development of a variety of inflammatory autoimmune diseases, such as rheumatic diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases that primarily affect connective tissues and are characterized by severe chronic inflammation and degeneration of connective tissues. Ginseng and its bioactive ingredients, genocides, have been demonstrated to have antiinflammatory activity and pharmacological effects on various rheumatic diseases by inhibiting the expression and production of inflammatory mediators. Methods: Literature in this review was searched in a PubMed site of National Center for Biotechnology Information. Results: The studies reporting the preventive and therapeutic effects of ginseng and ginsenosides on the pathogenesis of rheumatic diseases were discussed and summarized. Conclusion: Ginseng and ginsenosides play an ameliorative role on rheumatic diseases, and this review provides new insights into ginseng and ginsenosides as promising agents to prevent and treat rheumatic diseases. SN - 1226-8453 UR - https://www.unboundmedicine.com/medline/citation/31308803/Ameliorative_effects_of_ginseng_and_ginsenosides_on_rheumatic_diseases L2 - https://linkinghub.elsevier.com/retrieve/pii/S1226-8453(18)30062-9 DB - PRIME DP - Unbound Medicine ER -
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