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Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster.
Neurochem Res. 2019 Aug; 44(8):1986-1998.NR

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with oxidative stress. Therefore, finding new antioxidant sources might be beneficial for its treatment. Avocado Persea americana is a fruit widely cultivated in tropical and subtropical climates worldwide. Although avocado by-products in the form of peel, seed coat and seeds are currently of no commercial use, they constitute a natural source of bioactive compounds. Methanolic (80%) extract obtained from lyophilized ground peels, seed coats, and seeds of the avocado Hass, Fuerte, Reed and Colinred varieties were analyzed for their total phenolic content (TPC) and their correlations with antioxidant capacity (AC) were assessed by ABTS, FRAP, and ORAC assays. For all varieties, the var. Colinred peel shows the highest TPC and AC. Further analysis showed that the var. Colinred peel presented major phenolic compounds B-type procyanidins and epicatechin according to HPLC-MS. The antioxidant effect of peel extract was evaluated upon in vivo oxidative stress (OS) model. We show for the first time that the peel extract can protect and/or prevent transgenic parkinDrosophila melanogaster fly against paraquat-induced OS, movement impairment and lipid peroxidation, as model of PD. Our findings offer an exceptional opportunity to test natural disease-modifying substances from avocado's by-products.

Authors+Show Affiliations

Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, and Calle 62 # 52-59, Building 1, Room 412, SIU, Medellin, Colombia.Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, and Calle 62 # 52-59, Building 1, Room 412, SIU, Medellin, Colombia.Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), Calle 70 No. 52-21, and Calle 62 # 52-59, Building 1, Room 412, SIU, Medellin, Colombia. calberto.velez@udea.edu.co.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31309393

Citation

Ortega-Arellano, Hector Flavio, et al. "Neuroprotective Effects of Methanolic Extract of Avocado Persea Americana (var. Colinred) Peel On Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic Knockdown Parkin Drosophila Melanogaster." Neurochemical Research, vol. 44, no. 8, 2019, pp. 1986-1998.
Ortega-Arellano HF, Jimenez-Del-Rio M, Velez-Pardo C. Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster. Neurochem Res. 2019;44(8):1986-1998.
Ortega-Arellano, H. F., Jimenez-Del-Rio, M., & Velez-Pardo, C. (2019). Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster. Neurochemical Research, 44(8), 1986-1998. https://doi.org/10.1007/s11064-019-02835-z
Ortega-Arellano HF, Jimenez-Del-Rio M, Velez-Pardo C. Neuroprotective Effects of Methanolic Extract of Avocado Persea Americana (var. Colinred) Peel On Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic Knockdown Parkin Drosophila Melanogaster. Neurochem Res. 2019;44(8):1986-1998. PubMed PMID: 31309393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster. AU - Ortega-Arellano,Hector Flavio, AU - Jimenez-Del-Rio,Marlene, AU - Velez-Pardo,Carlos, Y1 - 2019/07/15/ PY - 2019/05/09/received PY - 2019/06/20/accepted PY - 2019/06/13/revised PY - 2019/7/17/pubmed PY - 2020/1/7/medline PY - 2019/7/17/entrez KW - Antioxidant capacity KW - Avocado KW - HPLC–MS KW - Methanolic extracts KW - Persea americana KW - Total phenolic content SP - 1986 EP - 1998 JF - Neurochemical research JO - Neurochem. Res. VL - 44 IS - 8 N2 - Parkinson's disease (PD) is a progressive neurodegenerative disorder associated with oxidative stress. Therefore, finding new antioxidant sources might be beneficial for its treatment. Avocado Persea americana is a fruit widely cultivated in tropical and subtropical climates worldwide. Although avocado by-products in the form of peel, seed coat and seeds are currently of no commercial use, they constitute a natural source of bioactive compounds. Methanolic (80%) extract obtained from lyophilized ground peels, seed coats, and seeds of the avocado Hass, Fuerte, Reed and Colinred varieties were analyzed for their total phenolic content (TPC) and their correlations with antioxidant capacity (AC) were assessed by ABTS, FRAP, and ORAC assays. For all varieties, the var. Colinred peel shows the highest TPC and AC. Further analysis showed that the var. Colinred peel presented major phenolic compounds B-type procyanidins and epicatechin according to HPLC-MS. The antioxidant effect of peel extract was evaluated upon in vivo oxidative stress (OS) model. We show for the first time that the peel extract can protect and/or prevent transgenic parkinDrosophila melanogaster fly against paraquat-induced OS, movement impairment and lipid peroxidation, as model of PD. Our findings offer an exceptional opportunity to test natural disease-modifying substances from avocado's by-products. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/31309393/Neuroprotective_Effects_of_Methanolic_Extract_of_Avocado_Persea_americana__var__Colinred__Peel_on_Paraquat_Induced_Locomotor_Impairment_Lipid_Peroxidation_and_Shortage_of_Life_Span_in_Transgenic_knockdown_Parkin_Drosophila_melanogaster_ L2 - https://doi.org/10.1007/s11064-019-02835-z DB - PRIME DP - Unbound Medicine ER -