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Intravenous immunoglobulin therapy: a snapshot for the internist.

Abstract

Intravenous immunoglobulins are the cornerstone for the treatment of primary humoral immunodeficiencies and may be used for a great number of other autoimmune, neurological and hematological conditions as well. Given their wide application, the possibility of running across a patient who needs this kind of therapy is becoming increasingly common. Generally, intravenous immunoglobulins are well tolerated. However, numerous adverse reactions ranging from mild to severe have been reported and linked to patient- and product-related factors. For all these reasons, we present herein a comprehensive review of the on- and off-label applications of intravenous immunoglobulins and provide a guide for the internist how to minimize the risk of adverse reactions and manage them.

Authors+Show Affiliations

Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy. gianfranco.vitiello@unifi.it.Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy.Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy.Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy.Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy.Experimental and Clinical Medicine Department, University of Firenze, Largo Brambilla 3, 50100, Firenze, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31309519

Citation

Vitiello, Gianfranco, et al. "Intravenous Immunoglobulin Therapy: a Snapshot for the Internist." Internal and Emergency Medicine, 2019.
Vitiello G, Emmi G, Silvestri E, et al. Intravenous immunoglobulin therapy: a snapshot for the internist. Intern Emerg Med. 2019.
Vitiello, G., Emmi, G., Silvestri, E., Di Scala, G., Palterer, B., & Parronchi, P. (2019). Intravenous immunoglobulin therapy: a snapshot for the internist. Internal and Emergency Medicine, doi:10.1007/s11739-019-02150-z.
Vitiello G, et al. Intravenous Immunoglobulin Therapy: a Snapshot for the Internist. Intern Emerg Med. 2019 Jul 15; PubMed PMID: 31309519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravenous immunoglobulin therapy: a snapshot for the internist. AU - Vitiello,Gianfranco, AU - Emmi,Giacomo, AU - Silvestri,Elena, AU - Di Scala,Gerardo, AU - Palterer,Boaz, AU - Parronchi,Paola, Y1 - 2019/07/15/ PY - 2019/05/24/received PY - 2019/07/05/accepted PY - 2019/7/17/entrez KW - Adverse drug reactions KW - Autoimmune diseases KW - IVIg KW - Immunodeficiency KW - Immunoglobulins JF - Internal and emergency medicine JO - Intern Emerg Med N2 - Intravenous immunoglobulins are the cornerstone for the treatment of primary humoral immunodeficiencies and may be used for a great number of other autoimmune, neurological and hematological conditions as well. Given their wide application, the possibility of running across a patient who needs this kind of therapy is becoming increasingly common. Generally, intravenous immunoglobulins are well tolerated. However, numerous adverse reactions ranging from mild to severe have been reported and linked to patient- and product-related factors. For all these reasons, we present herein a comprehensive review of the on- and off-label applications of intravenous immunoglobulins and provide a guide for the internist how to minimize the risk of adverse reactions and manage them. SN - 1970-9366 UR - https://www.unboundmedicine.com/medline/citation/31309519/Intravenous_immunoglobulin_therapy:_a_snapshot_for_the_internist L2 - https://dx.doi.org/10.1007/s11739-019-02150-z DB - PRIME DP - Unbound Medicine ER -