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Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly.
AJR Am J Roentgenol. 2019 10; 213(4):925-931.AA

Abstract

OBJECTIVE.

The purpose of our study was to assess whether linear ventricular dimensions-specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)-are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND

METHODS.

We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio.

RESULTS.

Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95% CI, -0.04 to 0.14) and 0.03 (95% CI, -0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86-0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79-0.87).

CONCLUSION.

FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly.

Authors+Show Affiliations

Department of Radiology and Imaging Sciences, Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Dr, Indianapolis, IN 46202. Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.Department of Radiology and Imaging Sciences, Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Dr, Indianapolis, IN 46202. Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.Department of Radiology, Texas Children's Hospital, Houston, TX.Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.Department of Neurological Surgery, Indiana University School of Medicine, Riley Hospital for Children at Indiana University Health, Indianapolis, IN.Department of Radiology and Imaging Sciences, Riley Hospital for Children at Indiana University Health, 705 Riley Hospital Dr, Indianapolis, IN 46202. Department of Radiology and imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.

Pub Type(s)

Comparative Study
Journal Article
Validation Study

Language

eng

PubMed ID

31310185

Citation

Radhakrishnan, Rupa, et al. "Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly." AJR. American Journal of Roentgenology, vol. 213, no. 4, 2019, pp. 925-931.
Radhakrishnan R, Brown BP, Kralik SF, et al. Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly. AJR Am J Roentgenol. 2019;213(4):925-931.
Radhakrishnan, R., Brown, B. P., Kralik, S. F., Bain, D., Persohn, S., Territo, P. R., Jea, A., & Karmazyn, B. (2019). Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly. AJR. American Journal of Roentgenology, 213(4), 925-931. https://doi.org/10.2214/AJR.19.21261
Radhakrishnan R, et al. Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly. AJR Am J Roentgenol. 2019;213(4):925-931. PubMed PMID: 31310185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile Ventriculomegaly. AU - Radhakrishnan,Rupa, AU - Brown,Brandon Patrick, AU - Kralik,Stephen F, AU - Bain,Danielle, AU - Persohn,Scott, AU - Territo,Paul R, AU - Jea,Andrew, AU - Karmazyn,Boaz, Y1 - 2019/07/16/ PY - 2019/7/17/pubmed PY - 2020/1/22/medline PY - 2019/7/17/entrez KW - hydrocephalus KW - interobserver concordance KW - posthemorrhagic hydrocephalus KW - preterm brain imaging KW - ventriculomegaly SP - 925 EP - 931 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 213 IS - 4 N2 - OBJECTIVE. The purpose of our study was to assess whether linear ventricular dimensions-specifically, the frontal occipital horn ratio (FOHR) and frontal temporal horn ratio (FTHR) obtained from ultrasound (US)-are reliable measures of ventriculomegaly in infants. Our hypothesis was that these US measures would show good correlation with linear ventricular indexes and ventricular volumes obtained from MRI. MATERIALS AND METHODS. We retrospectively identified 90 infants (age ≤ 6 months corrected gestational age) with ventriculomegaly from 2014 to 2017 who had a total of 100 sets of US and MRI studies performed in a 3-day period. FOHR and FTHR were independently measured on US and MRI by two pediatric radiologists and two pediatric neuroradiologists, respectively. Ventricular and brain volumes were segmented from the MR images, and the ventricle-to-intracranial volume ratio was calculated. MRI served as the reference standard. Intraclass correlation coefficients and Bland-Altman analyses were generated to evaluate interobserver and US-MRI concordance. We assessed correlation of the FOHR and FTHR with the ventricle-to-intracranial volume ratio. RESULTS. Bland-Altman plots of the FOHR and FTHR between US and MRI showed excellent concordance with a bias of 0.05 (95% CI, -0.04 to 0.14) and 0.03 (95% CI, -0.06 to 0.13), respectively. There was good-to-excellent interobserver concordance for FOHR and FTHR on head US or MRI (r = 0.86-0.96). There was good correlation between ventricle-to-intracranial volume ratios and US- and MRI-derived FOHRs and FTHRs (r = 0.79-0.87). CONCLUSION. FOHR and FTHR obtained from US in infants with ventriculomegaly have excellent interobserver concordance, are concordant with MRI-derived linear ratios, and correlate with MRI-derived ventricular volumes. Therefore, US-derived FOHR and FTHR are reliable indexes for clinical follow-up of infantile ventriculomegaly. SN - 1546-3141 UR - https://www.unboundmedicine.com/medline/citation/31310185/Frontal_Occipital_and_Frontal_Temporal_Horn_Ratios:_Comparison_and_Validation_of_Head_Ultrasound_Derived_Indexes_With_MRI_and_Ventricular_Volumes_in_Infantile_Ventriculomegaly_ L2 - http://www.ajronline.org/doi/full/10.2214/AJR.19.21261 DB - PRIME DP - Unbound Medicine ER -