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Variations in sleep associated with different types of hormonal contraceptives.
Gynecol Endocrinol 2019; :1-5GE

Abstract

Progesterone and some of its metabolites are neuroactive steroids that affect sleep by increasing melatonin secretion and stimulating GABA-A receptors. The effect of progestogens in hormonal contraceptives on sleep has not been thoroughly investigated. This observational study assessed possible associations in sleep changes induced by estrogen-progestogens in contraceptives in 108 women between the ages of 20 and 50 years. We assessed mean nightly sleep time with a 31-day sleep diary, and subjective sleep quality with the five subjective subscores of the Pittsburgh Sleep Quality Index (PSQI). Included women were of childbearing age, healthy, sexually active and had been using a hormonal contraceptive method (pill, intrauterine system (IUS), subcutaneous implant, vaginal ring) for at least six months. Results were compared to a matched control group that did not use hormonal contraceptives. The longest mean nightly sleep time, compared to control (450 min), occurred in women who used progestogen-only oral contraception (510 min), followed by IUS delivery of levonorgestrel 13.5 mg (480 min) and oral ethinylestradiol 0.02/0.03 mg plus gestodene 0.075 mg (475 min). Global subjective sleep quality was influenced most by the administration of etonorgestrel 0.120 mg/ethinylestradiol 0.015 mg via the vaginal route. Our results show that low-doses of progestins affect various aspects of sleep, and that this is influenced by the route of administration.

Authors+Show Affiliations

a Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana" , Università degli Studi di Salerno , Salerno , Italy.a Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana" , Università degli Studi di Salerno , Salerno , Italy.a Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana" , Università degli Studi di Salerno , Salerno , Italy.b Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine , University of Naples "Federico II" , Naples , Italy.b Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine , University of Naples "Federico II" , Naples , Italy.c Department of Experimental and Clinical Medicine Unit of Obstetrics , Gynecology University of Catanzaro "Magna Graecia" , Catanzaro , Italy.a Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana" , Università degli Studi di Salerno , Salerno , Italy.a Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana" , Università degli Studi di Salerno , Salerno , Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31311352

Citation

Guida, Maurizio, et al. "Variations in Sleep Associated With Different Types of Hormonal Contraceptives." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2019, pp. 1-5.
Guida M, Rega A, Vivone I, et al. Variations in sleep associated with different types of hormonal contraceptives. Gynecol Endocrinol. 2019.
Guida, M., Rega, A., Vivone, I., Saccone, G., Sarno, L., Di Carlo, C., ... Troisi, J. (2019). Variations in sleep associated with different types of hormonal contraceptives. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, pp. 1-5. doi:10.1080/09513590.2019.1640204.
Guida M, et al. Variations in Sleep Associated With Different Types of Hormonal Contraceptives. Gynecol Endocrinol. 2019 Jul 17;1-5. PubMed PMID: 31311352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Variations in sleep associated with different types of hormonal contraceptives. AU - Guida,Maurizio, AU - Rega,Alessia, AU - Vivone,Imma, AU - Saccone,Gabriele, AU - Sarno,Laura, AU - Di Carlo,Costantino, AU - Aquino,Carmen Imma, AU - Troisi,Jacopo, Y1 - 2019/07/17/ PY - 2019/7/18/entrez KW - Hormonal contraceptives KW - administration route KW - progestin KW - sleep duration KW - sleep quality SP - 1 EP - 5 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. N2 - Progesterone and some of its metabolites are neuroactive steroids that affect sleep by increasing melatonin secretion and stimulating GABA-A receptors. The effect of progestogens in hormonal contraceptives on sleep has not been thoroughly investigated. This observational study assessed possible associations in sleep changes induced by estrogen-progestogens in contraceptives in 108 women between the ages of 20 and 50 years. We assessed mean nightly sleep time with a 31-day sleep diary, and subjective sleep quality with the five subjective subscores of the Pittsburgh Sleep Quality Index (PSQI). Included women were of childbearing age, healthy, sexually active and had been using a hormonal contraceptive method (pill, intrauterine system (IUS), subcutaneous implant, vaginal ring) for at least six months. Results were compared to a matched control group that did not use hormonal contraceptives. The longest mean nightly sleep time, compared to control (450 min), occurred in women who used progestogen-only oral contraception (510 min), followed by IUS delivery of levonorgestrel 13.5 mg (480 min) and oral ethinylestradiol 0.02/0.03 mg plus gestodene 0.075 mg (475 min). Global subjective sleep quality was influenced most by the administration of etonorgestrel 0.120 mg/ethinylestradiol 0.015 mg via the vaginal route. Our results show that low-doses of progestins affect various aspects of sleep, and that this is influenced by the route of administration. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/31311352/Variations_in_sleep_associated_with_different_types_of_hormonal_contraceptives L2 - http://www.tandfonline.com/doi/full/10.1080/09513590.2019.1640204 DB - PRIME DP - Unbound Medicine ER -