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The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service.
Osteoporos Int. 2019 Sep; 30(9):1789-1797.OI

Abstract

We evaluated the association between prevalent vertebral fractures and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women with a recent non-vertebral fracture visiting the Fracture Liaison Service. The presence and severity of prevalent vertebral fracture reflect generalized bone deterioration.

INTRODUCTION

We evaluated the association between prevalent vertebral fractures (VFs) and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women visiting the Fracture Liaison Service.

METHODS

In this cross-sectional study in women aged 50-90 with a recent non-vertebral fracture (NVF), VFs were identified on lateral spine images by dual-energy X-ray absorptiometry. Bone micro-architecture and strength were measured at the non-dominant distal radius and distal tibia using HR-pQCT. Linear regression analyses were used to estimate the association between prevalent VFs and HR-pQCT parameters.

RESULTS

We included 338 women of whom 74 (21.9%) women had at least one prevalent VF. After adjustment for femoral neck aBMD (FN aBMD) and other parameters, women with at least one prevalent vertebral fracture had significantly lower total and trabecular vBMD and trabecular number (β - 16.7, - 11.8, and - 7.8 in the radius and - 21.4, - 16.6, and - 7.2 in the tibia, respectively), higher trabecular separation at the radius and tibia (β 9.0 and 9.3, respectively), and lower cortical thickness and calculated ultimate failure load and compressive bone strength at the tibia (β - 5.9, - 0.6, and - 10.9, respectively) as compared with those without prevalent VFs. Furthermore, more severe prevalent VFs were associated with even lower total and trabecular vBMD and lower ultimate failure load and compressive stiffness at the radius and tibia, and lower trabecular number and higher trabecular separation at the radius.

CONCLUSION

This study indicates that the presence and severity of prevalent VFs reflect generalized bone deterioration in women with a recent NVF, independently of FN aBMD.

Authors+Show Affiliations

Department of Internal Medicine, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands. Department of Internal Medicine, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.Department of Internal Medicine, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands. Department of Internal Medicine, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.Faculty of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Department of Orthopaedic Surgery, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. Department of Clinical Pharmacy and Toxicology, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands.CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. Department of Internal Medicine, Subdivision Rheumatology, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Biomedical Research Center, Hasselt University, Agoralaan, Gebouw D, 3590, Diepenbeek, Belgium.Department of Surgery, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands.Department of Internal Medicine, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands. Department of Internal Medicine, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.Department of Internal Medicine, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands. jvdbergh@viecuri.nl. Department of Internal Medicine, Maastricht University Medical Center +, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. jvdbergh@viecuri.nl. NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands. jvdbergh@viecuri.nl. Biomedical Research Center, Hasselt University, Agoralaan, Gebouw D, 3590, Diepenbeek, Belgium. jvdbergh@viecuri.nl. Department of Surgery, VieCuri Medical Center, P.O. Box 1926, 5900 BX, Venlo, The Netherlands. jvdbergh@viecuri.nl.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31312863

Citation

Vranken, L, et al. "The Association Between Prevalent Vertebral Fractures and Bone Quality of the Distal Radius and Distal Tibia as Measured With HR-pQCT in Postmenopausal Women With a Recent Non-vertebral Fracture at the Fracture Liaison Service." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 30, no. 9, 2019, pp. 1789-1797.
Vranken L, Wyers CE, van Rietbergen B, et al. The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service. Osteoporos Int. 2019;30(9):1789-1797.
Vranken, L., Wyers, C. E., van Rietbergen, B., Driessen, J. H. M., Geusens, P. P. M. M., Janzing, H. M. J., van der Velde, R. Y., & van den Bergh, J. P. W. (2019). The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30(9), 1789-1797. https://doi.org/10.1007/s00198-019-05081-9
Vranken L, et al. The Association Between Prevalent Vertebral Fractures and Bone Quality of the Distal Radius and Distal Tibia as Measured With HR-pQCT in Postmenopausal Women With a Recent Non-vertebral Fracture at the Fracture Liaison Service. Osteoporos Int. 2019;30(9):1789-1797. PubMed PMID: 31312863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service. AU - Vranken,L, AU - Wyers,C E, AU - van Rietbergen,B, AU - Driessen,J H M, AU - Geusens,P P M M, AU - Janzing,H M J, AU - van der Velde,R Y, AU - van den Bergh,J P W, Y1 - 2019/07/17/ PY - 2018/10/17/received PY - 2019/07/03/accepted PY - 2019/7/18/pubmed PY - 2020/2/11/medline PY - 2019/7/18/entrez KW - Fracture Liaison Service KW - HR-pQCT KW - Vertebral fractures SP - 1789 EP - 1797 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 30 IS - 9 N2 - : We evaluated the association between prevalent vertebral fractures and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women with a recent non-vertebral fracture visiting the Fracture Liaison Service. The presence and severity of prevalent vertebral fracture reflect generalized bone deterioration. INTRODUCTION: We evaluated the association between prevalent vertebral fractures (VFs) and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women visiting the Fracture Liaison Service. METHODS: In this cross-sectional study in women aged 50-90 with a recent non-vertebral fracture (NVF), VFs were identified on lateral spine images by dual-energy X-ray absorptiometry. Bone micro-architecture and strength were measured at the non-dominant distal radius and distal tibia using HR-pQCT. Linear regression analyses were used to estimate the association between prevalent VFs and HR-pQCT parameters. RESULTS: We included 338 women of whom 74 (21.9%) women had at least one prevalent VF. After adjustment for femoral neck aBMD (FN aBMD) and other parameters, women with at least one prevalent vertebral fracture had significantly lower total and trabecular vBMD and trabecular number (β - 16.7, - 11.8, and - 7.8 in the radius and - 21.4, - 16.6, and - 7.2 in the tibia, respectively), higher trabecular separation at the radius and tibia (β 9.0 and 9.3, respectively), and lower cortical thickness and calculated ultimate failure load and compressive bone strength at the tibia (β - 5.9, - 0.6, and - 10.9, respectively) as compared with those without prevalent VFs. Furthermore, more severe prevalent VFs were associated with even lower total and trabecular vBMD and lower ultimate failure load and compressive stiffness at the radius and tibia, and lower trabecular number and higher trabecular separation at the radius. CONCLUSION: This study indicates that the presence and severity of prevalent VFs reflect generalized bone deterioration in women with a recent NVF, independently of FN aBMD. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/31312863/The_association_between_prevalent_vertebral_fractures_and_bone_quality_of_the_distal_radius_and_distal_tibia_as_measured_with_HR_pQCT_in_postmenopausal_women_with_a_recent_non_vertebral_fracture_at_the_Fracture_Liaison_Service_ L2 - https://doi.org/10.1007/s00198-019-05081-9 DB - PRIME DP - Unbound Medicine ER -