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The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes.
BMC Endocr Disord 2019; 19(1):76BE

Abstract

BACKGROUND

Sarcopenic obesity, central obesity combined with decreased skeletal muscle mass, is identified to be associated with metabolic syndrome and cardiovascular diseases; however, its role in the occurrence of non-alcoholic fatty liver disease (NAFLD) among patients with type 2 diabetes mellitus (T2DM) remains unclear. Therefore, this study aimed to investigate the value of the skeletal-to-visceral ratio (SVR) in the prediction of NAFLD in T2DM.

METHODS

T2DM patients (n = 445) were recruited into the current study. Hepatic steatosis was diagnosed based on ultrasonic results, while skeletal muscle mass as well as visceral fat area (VFA) was estimated based on bioimpedance analysis measurements.

RESULTS

NAFLD prevalence increased with the decreased SVR tertiles: statistically significant differences were observed in the highest tertiles (21.5% in men, and 30.4% in women) and the lowest tertiles (53.9% in men and 60.0% in women) (both P < 0.01). The decreased SVR tertiles were independently associated with the presence of NAFLD in female T2DM patients, with the odds ratio (OR) of 3.43 and 2.31 in the lowest and middle tertiles, respectively. Besides, the areas under the curve (AUC) for identifying NAFLD were 0.675 and 0.63 in men and women, respectively (P < 0.05).

CONCLUSIONS

T2DM patients who have lower SVR levels are associated with higher risks of developing the NAFLD-related complications. Besides, SVR shows independent correlation with NAFLD in female T2DM patients, suggesting that SVR may be a useful index to predict the high risk of hepatic steatosis in T2DM.

Authors+Show Affiliations

Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District Wenzhou, Wenzhou, Zhejiang Province, People's Republic of China.Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District Wenzhou, Wenzhou, Zhejiang Province, People's Republic of China.Diabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Lucheng District Wenzhou, Wenzhou, Zhejiang Province, People's Republic of China. zhengchao_3@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31315613

Citation

Su, Xiaoyou, et al. "The Relationship Between Non-alcoholic Fatty Liver and Skeletal Muscle Mass to Visceral Fat Area Ratio in Women With Type 2 Diabetes." BMC Endocrine Disorders, vol. 19, no. 1, 2019, p. 76.
Su X, Xu J, Zheng C. The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocr Disord. 2019;19(1):76.
Su, X., Xu, J., & Zheng, C. (2019). The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. BMC Endocrine Disorders, 19(1), p. 76. doi:10.1186/s12902-019-0404-1.
Su X, Xu J, Zheng C. The Relationship Between Non-alcoholic Fatty Liver and Skeletal Muscle Mass to Visceral Fat Area Ratio in Women With Type 2 Diabetes. BMC Endocr Disord. 2019 Jul 17;19(1):76. PubMed PMID: 31315613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between non-alcoholic fatty liver and skeletal muscle mass to visceral fat area ratio in women with type 2 diabetes. AU - Su,Xiaoyou, AU - Xu,Jing, AU - Zheng,Chao, Y1 - 2019/07/17/ PY - 2019/02/16/received PY - 2019/07/10/accepted PY - 2019/7/19/entrez PY - 2019/7/19/pubmed PY - 2019/7/19/medline KW - Non-alcoholic fatty liver KW - Skeletal muscle mass KW - Skeletal muscle mass to visceral fat area ratio KW - Type 2 diabetes KW - Visceral fat area SP - 76 EP - 76 JF - BMC endocrine disorders JO - BMC Endocr Disord VL - 19 IS - 1 N2 - BACKGROUND: Sarcopenic obesity, central obesity combined with decreased skeletal muscle mass, is identified to be associated with metabolic syndrome and cardiovascular diseases; however, its role in the occurrence of non-alcoholic fatty liver disease (NAFLD) among patients with type 2 diabetes mellitus (T2DM) remains unclear. Therefore, this study aimed to investigate the value of the skeletal-to-visceral ratio (SVR) in the prediction of NAFLD in T2DM. METHODS: T2DM patients (n = 445) were recruited into the current study. Hepatic steatosis was diagnosed based on ultrasonic results, while skeletal muscle mass as well as visceral fat area (VFA) was estimated based on bioimpedance analysis measurements. RESULTS: NAFLD prevalence increased with the decreased SVR tertiles: statistically significant differences were observed in the highest tertiles (21.5% in men, and 30.4% in women) and the lowest tertiles (53.9% in men and 60.0% in women) (both P < 0.01). The decreased SVR tertiles were independently associated with the presence of NAFLD in female T2DM patients, with the odds ratio (OR) of 3.43 and 2.31 in the lowest and middle tertiles, respectively. Besides, the areas under the curve (AUC) for identifying NAFLD were 0.675 and 0.63 in men and women, respectively (P < 0.05). CONCLUSIONS: T2DM patients who have lower SVR levels are associated with higher risks of developing the NAFLD-related complications. Besides, SVR shows independent correlation with NAFLD in female T2DM patients, suggesting that SVR may be a useful index to predict the high risk of hepatic steatosis in T2DM. SN - 1472-6823 UR - https://www.unboundmedicine.com/medline/citation/31315613/The_relationship_between_non-alcoholic_fatty_liver_and_skeletal_muscle_mass_to_visceral_fat_area_ratio_in_women_with_type_2_diabetes L2 - https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s12902-019-0404-1 DB - PRIME DP - Unbound Medicine ER -