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Physiological Significance of NAD Kinases in Cyanobacteria.
Front Plant Sci 2019; 10:847FP

Abstract

Unicellular cyanobacteria are thought to be the evolutionary ancestors of plant chloroplasts and are widely used both for chemical production and as model organisms in studies of photosynthesis. Although most research focused on increasing reducing power (that is, NADPH) as target of metabolic engineering, the physiological roles of NAD(P)(H) in cyanobacteria poorly understood. In cyanobacteria such as the model species Synechocystis sp. PCC 6803, most metabolic pathways share a single compartment. This complex metabolism raises the question of how cyanobacteria control the amounts of the redox pairs NADH/NAD+ and NADPH/NADP+ in the cyanobacterial metabolic pathways. For example, photosynthetic and respiratory electron transport chains share several redox components in the thylakoid lumen, including plastoquinone, cytochrome b6f (cyt b6f), and the redox carriers plastocyanin and cytochrome c6. In the case of photosynthesis, NADP+ acts as an important electron mediator on the acceptor-side of photosystem I (PSI) in the linear electron chain as well as in the plant chloroplast. Meanwhile, in respiration, most electrons derived from NADPH and NADH are transferred by NAD(P)H dehydrogenases. Therefore, it is expected that Synechocystis employs unique NAD(P)(H) -pool control mechanisms to regulate the mixed metabolic systems involved in photosynthesis and respiration. This review article summarizes the current state of knowledge of NAD(P)(H) metabolism in Synechocystis. In particular, we focus on the physiological function in Synechocystis of NAD kinase, the enzyme that phosphorylates NAD+ to NADP+.

Authors+Show Affiliations

Graduate School of Science and Engineering, Saitama University, Saitama, Japan.Graduate School of Science and Engineering, Saitama University, Saitama, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31316540

Citation

Ishikawa, Yuuma, and Maki Kawai-Yamada. "Physiological Significance of NAD Kinases in Cyanobacteria." Frontiers in Plant Science, vol. 10, 2019, p. 847.
Ishikawa Y, Kawai-Yamada M. Physiological Significance of NAD Kinases in Cyanobacteria. Front Plant Sci. 2019;10:847.
Ishikawa, Y., & Kawai-Yamada, M. (2019). Physiological Significance of NAD Kinases in Cyanobacteria. Frontiers in Plant Science, 10, p. 847. doi:10.3389/fpls.2019.00847.
Ishikawa Y, Kawai-Yamada M. Physiological Significance of NAD Kinases in Cyanobacteria. Front Plant Sci. 2019;10:847. PubMed PMID: 31316540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physiological Significance of NAD Kinases in Cyanobacteria. AU - Ishikawa,Yuuma, AU - Kawai-Yamada,Maki, Y1 - 2019/06/27/ PY - 2019/03/20/received PY - 2019/06/13/accepted PY - 2019/7/19/entrez PY - 2019/7/19/pubmed PY - 2019/7/19/medline KW - NAD KW - NAD kinase KW - Synechocystis KW - cyanobacteria KW - metabolism SP - 847 EP - 847 JF - Frontiers in plant science JO - Front Plant Sci VL - 10 N2 - Unicellular cyanobacteria are thought to be the evolutionary ancestors of plant chloroplasts and are widely used both for chemical production and as model organisms in studies of photosynthesis. Although most research focused on increasing reducing power (that is, NADPH) as target of metabolic engineering, the physiological roles of NAD(P)(H) in cyanobacteria poorly understood. In cyanobacteria such as the model species Synechocystis sp. PCC 6803, most metabolic pathways share a single compartment. This complex metabolism raises the question of how cyanobacteria control the amounts of the redox pairs NADH/NAD+ and NADPH/NADP+ in the cyanobacterial metabolic pathways. For example, photosynthetic and respiratory electron transport chains share several redox components in the thylakoid lumen, including plastoquinone, cytochrome b6f (cyt b6f), and the redox carriers plastocyanin and cytochrome c6. In the case of photosynthesis, NADP+ acts as an important electron mediator on the acceptor-side of photosystem I (PSI) in the linear electron chain as well as in the plant chloroplast. Meanwhile, in respiration, most electrons derived from NADPH and NADH are transferred by NAD(P)H dehydrogenases. Therefore, it is expected that Synechocystis employs unique NAD(P)(H) -pool control mechanisms to regulate the mixed metabolic systems involved in photosynthesis and respiration. This review article summarizes the current state of knowledge of NAD(P)(H) metabolism in Synechocystis. In particular, we focus on the physiological function in Synechocystis of NAD kinase, the enzyme that phosphorylates NAD+ to NADP+. SN - 1664-462X UR - https://www.unboundmedicine.com/medline/citation/31316540/Physiological_Significance_of_NAD_Kinases_in_Cyanobacteria L2 - https://dx.doi.org/10.3389/fpls.2019.00847 DB - PRIME DP - Unbound Medicine ER -