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Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models.

Abstract

Cnidium officinale, widely cultivated in East Asia, has been reported to exhibit pharmacological efficacy in various disorders. However, little has been reported on its role as a pain killer. In this study, we reveal that the C. officinale extract (COE) has great efficacy as a novel analgesic in various in vivo pain models. Administration of COE attenuated hypersensitivity in all postoperative, neuropathic, and menopausal pain models. Decreased hyperalgesia was confirmed by a mechanical withdrawal threshold assay and ultrasonic vocalization call analysis. In addition, application of COE inhibited the induction of the proinflammatory cytokines and calpain-3 on dorsal root ganglion neurons in a spared nerve injury rat model. Treatment with ferulic acid, which was identified as one of the components of COE by HPLC analysis, alleviated nociceptive behaviors. Our findings suggest that ferulic acid is an active compound from COE, and COE is a potential phytomedical source for pain relief by inhibiting the process of inflammation.

Authors+Show Affiliations

Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea. Department of Food Biotechnology, Korea University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea.Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea.Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea.Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea.Division of Functional Food Research, Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Republic of Korea. Department of Food Biotechnology, Korea University of Science & Technology, 217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31316578

Citation

Lim, Eun Yeong, et al. "Analgesic Effects of Cnidium Officinale Extracts On Postoperative, Neuropathic, and Menopausal Pain in Rat Models." Evidence-based Complementary and Alternative Medicine : ECAM, vol. 2019, 2019, p. 9698727.
Lim EY, Kim JG, Lee J, et al. Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evid Based Complement Alternat Med. 2019;2019:9698727.
Lim, E. Y., Kim, J. G., Lee, J., Lee, C., Shim, J., & Kim, Y. T. (2019). Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evidence-based Complementary and Alternative Medicine : ECAM, 2019, p. 9698727. doi:10.1155/2019/9698727.
Lim EY, et al. Analgesic Effects of Cnidium Officinale Extracts On Postoperative, Neuropathic, and Menopausal Pain in Rat Models. Evid Based Complement Alternat Med. 2019;2019:9698727. PubMed PMID: 31316578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models. AU - Lim,Eun Yeong, AU - Kim,Jae Goo, AU - Lee,Jaekwang, AU - Lee,Changho, AU - Shim,Jaewon, AU - Kim,Yun Tai, Y1 - 2019/06/16/ PY - 2019/02/22/received PY - 2019/06/02/accepted PY - 2019/7/19/entrez PY - 2019/7/19/pubmed PY - 2019/7/19/medline SP - 9698727 EP - 9698727 JF - Evidence-based complementary and alternative medicine : eCAM JO - Evid Based Complement Alternat Med VL - 2019 N2 - Cnidium officinale, widely cultivated in East Asia, has been reported to exhibit pharmacological efficacy in various disorders. However, little has been reported on its role as a pain killer. In this study, we reveal that the C. officinale extract (COE) has great efficacy as a novel analgesic in various in vivo pain models. Administration of COE attenuated hypersensitivity in all postoperative, neuropathic, and menopausal pain models. Decreased hyperalgesia was confirmed by a mechanical withdrawal threshold assay and ultrasonic vocalization call analysis. In addition, application of COE inhibited the induction of the proinflammatory cytokines and calpain-3 on dorsal root ganglion neurons in a spared nerve injury rat model. Treatment with ferulic acid, which was identified as one of the components of COE by HPLC analysis, alleviated nociceptive behaviors. Our findings suggest that ferulic acid is an active compound from COE, and COE is a potential phytomedical source for pain relief by inhibiting the process of inflammation. SN - 1741-427X UR - https://www.unboundmedicine.com/medline/citation/31316578/Analgesic_Effects_of_Cnidium_officinale_Extracts_on_Postoperative,_Neuropathic,_and_Menopausal_Pain_in_Rat_Models L2 - https://dx.doi.org/10.1155/2019/9698727 DB - PRIME DP - Unbound Medicine ER -