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Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet-fed Mice.
Mol Nutr Food Res 2019; :e1801417MN

Abstract

SCOPE

Gut microbiota plays an important role in the development of diet-induced obesity and metabolic syndrome. Glycerol monolaurate (GML), a widely consumed food emulsifier, has been reported to promote metabolic disorder and gut microbiota dysbiosis in low-dose supplementation upon low fat diet feeding. However, little is known about whether GML produce the same effects in mice fed a high fat diet (HFD).

METHODS AND RESULTS

C57BL/6 mice were fed a HFD with or without GML supplementation (150, 300 and 450 mg/kg) for 10 weeks. Our results demonstrated that higher GML treatment (450 mg/kg) ameliorated HFD-induced metabolic disorders, supported by prevented visceral fat deposition, improved serum hyperlipidemia, modulated hepatic lipid metabolism and reduced serum levels of proinflammatory cytokine, TNF-α. Additionally, circulating LPS load and insulin resistance were attenuated by all doses of GML supplementation. Notably, GML ameliorated HFD-induced gut microbiota dysbiosis, with increases in Bacteroides uniformis, Akkermansia, Bifidobacterium and Lactobacillus and decreases in Escherichia coli, Lactococcus and Flexispira. Spearman's correlation analysis indicated that these enriched specific genera are significantly associated with the metabolic improvements of GML.

CONCLUSION

Our findings identify the links between gut microbiota and GML-induced metabolic improvements, suggesting that the attenuation of HFD-induced metabolic disorders by higher GML supplementation might occur through targeting gut microbiota. This article is protected by copyright. All rights reserved.

Authors+Show Affiliations

M. Zhao, Y. Li, H. Zhong, H. Zhang, F. Feng, College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.H. Cai, Zhejiang Key Lab for Chem & Bio Processing Technology of Farm Product, Zhejiang University of Science and Technology, Hangzhou, 310023, China.Z. Jiang, Institute of Basic Medical Sciences, School of Life Sciences, Westlake University, Hangzhou, 310024, China.M. Zhao, Y. Li, H. Zhong, H. Zhang, F. Feng, College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.M. Zhao, Y. Li, H. Zhong, H. Zhang, F. Feng, College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.M. Zhao, Y. Li, H. Zhong, H. Zhang, F. Feng, College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.M. Zhao, Y. Li, H. Zhong, H. Zhang, F. Feng, College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31318165

Citation

Zhao, Minjie, et al. "Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome Is Associated With the Modulation of Gut Microbiota in High Fat Diet-fed Mice." Molecular Nutrition & Food Research, 2019, pp. e1801417.
Zhao M, Cai H, Jiang Z, et al. Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet-fed Mice. Mol Nutr Food Res. 2019.
Zhao, M., Cai, H., Jiang, Z., Li, Y., Zhong, H., Zhang, H., & Feng, F. (2019). Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet-fed Mice. Molecular Nutrition & Food Research, pp. e1801417. doi:10.1002/mnfr.201801417.
Zhao M, et al. Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome Is Associated With the Modulation of Gut Microbiota in High Fat Diet-fed Mice. Mol Nutr Food Res. 2019 Jul 18;e1801417. PubMed PMID: 31318165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycerol Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High Fat diet-fed Mice. AU - Zhao,Minjie, AU - Cai,Haiying, AU - Jiang,Zengliang, AU - Li,Yang, AU - Zhong,Hao, AU - Zhang,Hui, AU - Feng,Fengqin, Y1 - 2019/07/18/ PY - 2018/12/24/received PY - 2019/05/09/revised PY - 2019/7/19/entrez KW - glycerol monolaurate KW - gut microbiota KW - high fat diet KW - lipid metabolism KW - metabolic syndrome SP - e1801417 EP - e1801417 JF - Molecular nutrition & food research JO - Mol Nutr Food Res N2 - SCOPE: Gut microbiota plays an important role in the development of diet-induced obesity and metabolic syndrome. Glycerol monolaurate (GML), a widely consumed food emulsifier, has been reported to promote metabolic disorder and gut microbiota dysbiosis in low-dose supplementation upon low fat diet feeding. However, little is known about whether GML produce the same effects in mice fed a high fat diet (HFD). METHODS AND RESULTS: C57BL/6 mice were fed a HFD with or without GML supplementation (150, 300 and 450 mg/kg) for 10 weeks. Our results demonstrated that higher GML treatment (450 mg/kg) ameliorated HFD-induced metabolic disorders, supported by prevented visceral fat deposition, improved serum hyperlipidemia, modulated hepatic lipid metabolism and reduced serum levels of proinflammatory cytokine, TNF-α. Additionally, circulating LPS load and insulin resistance were attenuated by all doses of GML supplementation. Notably, GML ameliorated HFD-induced gut microbiota dysbiosis, with increases in Bacteroides uniformis, Akkermansia, Bifidobacterium and Lactobacillus and decreases in Escherichia coli, Lactococcus and Flexispira. Spearman's correlation analysis indicated that these enriched specific genera are significantly associated with the metabolic improvements of GML. CONCLUSION: Our findings identify the links between gut microbiota and GML-induced metabolic improvements, suggesting that the attenuation of HFD-induced metabolic disorders by higher GML supplementation might occur through targeting gut microbiota. This article is protected by copyright. All rights reserved. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/31318165/Glycerol_Monolaurate-Mediated_Attenuation_of_Metabolic_Syndrome_is_Associated_with_the_Modulation_of_Gut_Microbiota_in_High_Fat_diet-fed_Mice L2 - https://doi.org/10.1002/mnfr.201801417 DB - PRIME DP - Unbound Medicine ER -