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Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice.
Mol Nutr Food Res. 2019 09; 63(18):e1801417.MN

Abstract

SCOPE

The gut microbiota plays an important role in the development of diet-induced obesity and metabolic syndrome. Glycerol monolaurate (GML), a widely consumed food emulsifier, is reported to promote metabolic disorder and gut microbiota dysbiosis in low-dose supplementation upon low-fat-diet feeding. However, little is known about whether GML produce the same effects in mice fed a high-fat diet (HFD).

METHODS AND RESULTS

C57BL/6 mice are fed a HFD with or without GML supplementation (150, 300, and 450 mg kg-1) for 10 weeks. The results demonstrated that higher GML treatment (450 mg kg-1) ameliorates HFD-induced metabolic disorders, supported by prevented visceral fat deposition, improved hyperlipidemia, modulated hepatic lipid metabolism, and reduced serum proinflammatory cytokine, TNF-α. Additionally, all doses of GML attenuated circulating lipopolysaccharide load and insulin resistance. Notably, GML ameliorates HFD-induced gut microbiota dysbiosis, with increases in Bacteroides uniformis, Akkermansia, Bifidobacterium, and Lactobacillus and decreases in Escherichia coli, Lactococcus, and Flexispira. Spearman's correlation analysis indicates that these enriched specific genera are significantly associated with the metabolic improvements of GML.

CONCLUSION

The findings identify the links between gut microbiota and GML-induced metabolic improvements, suggesting that the attenuation of HFD-induced metabolic disorders by higher GML supplementation may occur through targeting gut microbiota.

Authors+Show Affiliations

College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.Zhejiang Key Lab for Chem & Bio Processing Technology of Farm Product, Zhejiang University of Science and Technology, Hangzhou, 310023, China.Institute of Basic Medical Sciences, School of Life Sciences, Westlake University, Hangzhou, 310024, China.College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.College of Biosystems Engineering and Food Science, National Engineering Laboratory of Intelligent Food Technology and Equipment, Key Laboratory for Agro-Products Postharvest Handling of Ministry of Agriculture, Key Laboratory for Agro-Products Nutritional Evaluation of Ministry of Agriculture, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, 310058, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31318165

Citation

Zhao, Minjie, et al. "Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome Is Associated With the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice." Molecular Nutrition & Food Research, vol. 63, no. 18, 2019, pp. e1801417.
Zhao M, Cai H, Jiang Z, et al. Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice. Mol Nutr Food Res. 2019;63(18):e1801417.
Zhao, M., Cai, H., Jiang, Z., Li, Y., Zhong, H., Zhang, H., & Feng, F. (2019). Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice. Molecular Nutrition & Food Research, 63(18), e1801417. https://doi.org/10.1002/mnfr.201801417
Zhao M, et al. Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome Is Associated With the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice. Mol Nutr Food Res. 2019;63(18):e1801417. PubMed PMID: 31318165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycerol-Monolaurate-Mediated Attenuation of Metabolic Syndrome is Associated with the Modulation of Gut Microbiota in High-Fat-Diet-Fed Mice. AU - Zhao,Minjie, AU - Cai,Haiying, AU - Jiang,Zengliang, AU - Li,Yang, AU - Zhong,Hao, AU - Zhang,Hui, AU - Feng,Fengqin, Y1 - 2019/08/29/ PY - 2018/12/24/received PY - 2019/05/09/revised PY - 2019/7/19/pubmed PY - 2019/7/19/medline PY - 2019/7/19/entrez KW - glycerol monolaurate KW - gut microbiota KW - high-fat diet KW - lipid metabolism KW - metabolic syndrome SP - e1801417 EP - e1801417 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 63 IS - 18 N2 - SCOPE: The gut microbiota plays an important role in the development of diet-induced obesity and metabolic syndrome. Glycerol monolaurate (GML), a widely consumed food emulsifier, is reported to promote metabolic disorder and gut microbiota dysbiosis in low-dose supplementation upon low-fat-diet feeding. However, little is known about whether GML produce the same effects in mice fed a high-fat diet (HFD). METHODS AND RESULTS: C57BL/6 mice are fed a HFD with or without GML supplementation (150, 300, and 450 mg kg-1) for 10 weeks. The results demonstrated that higher GML treatment (450 mg kg-1) ameliorates HFD-induced metabolic disorders, supported by prevented visceral fat deposition, improved hyperlipidemia, modulated hepatic lipid metabolism, and reduced serum proinflammatory cytokine, TNF-α. Additionally, all doses of GML attenuated circulating lipopolysaccharide load and insulin resistance. Notably, GML ameliorates HFD-induced gut microbiota dysbiosis, with increases in Bacteroides uniformis, Akkermansia, Bifidobacterium, and Lactobacillus and decreases in Escherichia coli, Lactococcus, and Flexispira. Spearman's correlation analysis indicates that these enriched specific genera are significantly associated with the metabolic improvements of GML. CONCLUSION: The findings identify the links between gut microbiota and GML-induced metabolic improvements, suggesting that the attenuation of HFD-induced metabolic disorders by higher GML supplementation may occur through targeting gut microbiota. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/31318165/Glycerol_Monolaurate-Mediated_Attenuation_of_Metabolic_Syndrome_is_Associated_with_the_Modulation_of_Gut_Microbiota_in_High_Fat_diet-fed_Mice L2 - https://doi.org/10.1002/mnfr.201801417 DB - PRIME DP - Unbound Medicine ER -
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