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Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet.

Abstract

Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made in a gastroenterology practice. From a conventional pathophysiological perspective GERD is conceptualized as incompetence of the antireflux barrier at the esophagogastric junction; the more severe that incompetence, the worse the disease. However, it is increasingly clear that many presentations of GERD represent distinct phenotypes with unique predisposing cofactors and pathophysiology outside of this paradigm. Three major consensus initiatives have grappled with this dilemma (the Montreal Consensus, The Rome Foundation, and the Lyon Consensus), each from a different perspective. Montreal struggled to define the disease, Rome sought to characterize its "functional" attributes, while Lyon examined its physiological attributes. Our objective in this review is to merge the three, developing the concept that what has come to be known as GERD is actually a family of syndromes with a complex matrix of contributing pathophysiology. A corollary to this is that the concept of one size fits all to therapeutics does not apply and that while escalating treatment with proton pump inhibitors (PPIs) may be pertinent to healing esophagitis, its applicability beyond that is highly questionable. Similarly, failing to recognize the modulating effects of anxiety, hypervigilance, visceral and central hypersensitivity on symptom severity has greatly over-simplified the problem. That over-simplification has led to excessive use of PPIs for everything captured under the GERD umbrella and revealed a broad spectrum of syndromes less amenable to PPI therapy in any dose. It is with this in mind that we delineate this precision medicine concept of GERD.

Authors+Show Affiliations

Mayo Clinic, Division of Gastroenterology and Hepatology, 200 First St., S.W., Rochester, MN 55905.Northwestern University, Feinberg School of Medicine, Department of Medicine, 676 St Clair Street, 14(th) floor, Chicago, Illinois 60611-2951, USA.Northwestern University, Feinberg School of Medicine, Department of Medicine, 676 St Clair Street, 14(th) floor, Chicago, Illinois 60611-2951, USA. Electronic address: p-kahrilas@northwestern.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31319183

Citation

Katzka, David A., et al. "Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 2019.
Katzka DA, Pandolfino JE, Kahrilas PJ. Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. Clin Gastroenterol Hepatol. 2019.
Katzka, D. A., Pandolfino, J. E., & Kahrilas, P. J. (2019). Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, doi:10.1016/j.cgh.2019.07.015.
Katzka DA, Pandolfino JE, Kahrilas PJ. Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. Clin Gastroenterol Hepatol. 2019 Jul 15; PubMed PMID: 31319183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet. AU - Katzka,David A, AU - Pandolfino,John E, AU - Kahrilas,Peter J, Y1 - 2019/07/15/ PY - 2019/05/17/received PY - 2019/06/25/revised PY - 2019/07/03/accepted PY - 2019/7/19/entrez PY - 2019/7/19/pubmed PY - 2019/7/19/medline JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. N2 - Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made in a gastroenterology practice. From a conventional pathophysiological perspective GERD is conceptualized as incompetence of the antireflux barrier at the esophagogastric junction; the more severe that incompetence, the worse the disease. However, it is increasingly clear that many presentations of GERD represent distinct phenotypes with unique predisposing cofactors and pathophysiology outside of this paradigm. Three major consensus initiatives have grappled with this dilemma (the Montreal Consensus, The Rome Foundation, and the Lyon Consensus), each from a different perspective. Montreal struggled to define the disease, Rome sought to characterize its "functional" attributes, while Lyon examined its physiological attributes. Our objective in this review is to merge the three, developing the concept that what has come to be known as GERD is actually a family of syndromes with a complex matrix of contributing pathophysiology. A corollary to this is that the concept of one size fits all to therapeutics does not apply and that while escalating treatment with proton pump inhibitors (PPIs) may be pertinent to healing esophagitis, its applicability beyond that is highly questionable. Similarly, failing to recognize the modulating effects of anxiety, hypervigilance, visceral and central hypersensitivity on symptom severity has greatly over-simplified the problem. That over-simplification has led to excessive use of PPIs for everything captured under the GERD umbrella and revealed a broad spectrum of syndromes less amenable to PPI therapy in any dose. It is with this in mind that we delineate this precision medicine concept of GERD. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/31319183/Phenotypes_of_Gastroesophageal_Reflux_Disease:_Where_Rome,_Lyon,_and_Montreal_Meet L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(19)30748-7 DB - PRIME DP - Unbound Medicine ER -