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A network approach to investigate the bi-hemispheric synchrony in absence epilepsy.
Clin Neurophysiol 2019; 130(9):1611-1619CN

Abstract

OBJECTIVE

Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy.

METHODS

SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset.

RESULTS

A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset.

CONCLUSIONS

The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region.

SIGNIFICANCE

The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control.

Authors+Show Affiliations

Department of Mathematics & Computer Science, Eindhoven University of Technology, Eindhoven, The Netherlands; Academic Center for Epileptology Kempenhaeghe & Maastricht University Medical Center, Heeze, The Netherlands. Electronic address: possenblok@sein.nl.Academic Center for Epileptology Kempenhaeghe & Maastricht University Medical Center, Heeze, The Netherlands.Academic Center for Epileptology Kempenhaeghe & Maastricht University Medical Center, Heeze, The Netherlands.Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.Biological Psychology, Donders Centre of Cognition, Radboud University, Nijmegen, The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31319290

Citation

Ossenblok, Pauly, et al. "A Network Approach to Investigate the Bi-hemispheric Synchrony in Absence Epilepsy." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 130, no. 9, 2019, pp. 1611-1619.
Ossenblok P, van Houdt P, Colon A, et al. A network approach to investigate the bi-hemispheric synchrony in absence epilepsy. Clin Neurophysiol. 2019;130(9):1611-1619.
Ossenblok, P., van Houdt, P., Colon, A., Stroink, H., & van Luijtelaar, G. (2019). A network approach to investigate the bi-hemispheric synchrony in absence epilepsy. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 130(9), pp. 1611-1619. doi:10.1016/j.clinph.2019.05.034.
Ossenblok P, et al. A Network Approach to Investigate the Bi-hemispheric Synchrony in Absence Epilepsy. Clin Neurophysiol. 2019;130(9):1611-1619. PubMed PMID: 31319290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A network approach to investigate the bi-hemispheric synchrony in absence epilepsy. AU - Ossenblok,Pauly, AU - van Houdt,Petra, AU - Colon,Albert, AU - Stroink,Hans, AU - van Luijtelaar,Gilles, Y1 - 2019/07/01/ PY - 2019/02/11/received PY - 2019/05/11/revised PY - 2019/05/22/accepted PY - 2019/7/19/pubmed PY - 2019/7/19/medline PY - 2019/7/19/entrez KW - Childhood absence epilepsy KW - Driving sources KW - Local connectivity mapping KW - Treatment response SP - 1611 EP - 1619 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 130 IS - 9 N2 - OBJECTIVE: Our objective was to unravel the dynamics underlying spike-and-wave discharges (SWDs) characteristic for childhood absence epilepsy. METHODS: SWDs were recorded for a cohort of 28 children using magnetoencephalography. Non-linear association analyses and a graph theoretical metric of local connectedness (LoC) were utilized in a sliding window starting one s before till four s after ictal onset. RESULTS: A focal pattern of bilateral frontal and parietal areas with high LoC during the spikes alternated by generalized patterns during the waves was found for all children studied during generalization of the SWDs. In the interval preceding the generalization a focal parietal region was most often (16/28) encountered and less often an occipital (4/28), temporal (5/28) or frontal (3/28) region. 55% of the children with a parietal/occipital focal onset became seizure free after the administration of two anti-epileptic drugs, and only 12.5% with a temporal/frontal focal onset. CONCLUSIONS: The transition from the interictal to the ictal state is for some of the children characterized by dominant LoC at either the parietal/occipital and for others at the frontal/temporal region. SIGNIFICANCE: The focal onset of the SWDs varies in location among the children with a clinical similar profile, who, however, seemingly are differing with regard to seizure control. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/31319290/A_network_approach_to_investigate_the_bi-hemispheric_synchrony_in_absence_epilepsy L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(19)30918-6 DB - PRIME DP - Unbound Medicine ER -