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Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology.
Autops Case Rep 2019 Apr-Jun; 9(2):e2018092AC

Abstract

Fibrous dysplasia (FD) is a relatively rare osseous disease of unknown etiology, wherein the normal bone is replaced by collagen-rich tissue, comprising of fibroblasts and variably abundant immature woven bone. Clinically, it may involve a single bone or multiple bones. It commonly arises in the jaw bone, skull, rib, and proximal femur. Those arising in the skull and the jaw are together termed "craniofacial fibrous dysplasia." The differential diagnosis at this location includes meningioma and metastatic carcinoma. In this report, we highlight two diagnostically challenging cases presenting with orbital swelling and headache as the main complaints. Our first case was misinterpreted as meningioma on intraoperative squash smear, and paraffin sections revealed characteristic features of FD. The second case highlights the morphological feature of non-specific cystic degeneration occurring in FD. Radiographs in such cases show cystic swelling, which is indicative of a secondary aneurysmal bone cyst.

Authors+Show Affiliations

Postgraduate Institute of Medical Education and Research (PGIMER), Departments of Histopathology. Chandigarh, India.Postgraduate Institute of Medical Education and Research (PGIMER), Departments of Histopathology. Chandigarh, India.Postgraduate Institute of Medical Education and Research (PGIMER), Departments of Neurosurgery. Chandigarh, India.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31321219

Citation

Singh, Vikram, et al. "Monostotic Craniofacial Fibrous Dysplasia: Report of Two Cases With Interesting Histology." Autopsy & Case Reports, vol. 9, no. 2, 2019, pp. e2018092.
Singh V, Gupta K, Salunke P. Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology. Autops Case Rep. 2019;9(2):e2018092.
Singh, V., Gupta, K., & Salunke, P. (2019). Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology. Autopsy & Case Reports, 9(2), pp. e2018092. doi:10.4322/acr.2018.092.
Singh V, Gupta K, Salunke P. Monostotic Craniofacial Fibrous Dysplasia: Report of Two Cases With Interesting Histology. Autops Case Rep. 2019;9(2):e2018092. PubMed PMID: 31321219.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monostotic craniofacial fibrous dysplasia: report of two cases with interesting histology. AU - Singh,Vikram, AU - Gupta,Kirti, AU - Salunke,Pravin, Y1 - 2019/06/11/ PY - 2019/01/26/received PY - 2019/03/31/accepted PY - 2019/7/20/entrez PY - 2019/7/20/pubmed PY - 2019/7/20/medline KW - Bone Cysts, Aneurysmal KW - Fibrous Dysplasia, Monostotic KW - Meningioma SP - e2018092 EP - e2018092 JF - Autopsy & case reports JO - Autops Case Rep VL - 9 IS - 2 N2 - Fibrous dysplasia (FD) is a relatively rare osseous disease of unknown etiology, wherein the normal bone is replaced by collagen-rich tissue, comprising of fibroblasts and variably abundant immature woven bone. Clinically, it may involve a single bone or multiple bones. It commonly arises in the jaw bone, skull, rib, and proximal femur. Those arising in the skull and the jaw are together termed "craniofacial fibrous dysplasia." The differential diagnosis at this location includes meningioma and metastatic carcinoma. In this report, we highlight two diagnostically challenging cases presenting with orbital swelling and headache as the main complaints. Our first case was misinterpreted as meningioma on intraoperative squash smear, and paraffin sections revealed characteristic features of FD. The second case highlights the morphological feature of non-specific cystic degeneration occurring in FD. Radiographs in such cases show cystic swelling, which is indicative of a secondary aneurysmal bone cyst. SN - 2236-1960 UR - https://www.unboundmedicine.com/medline/citation/31321219/Monostotic_craniofacial_fibrous_dysplasia:_report_of_two_cases_with_interesting_histology L2 - http://dx.doi.org/10.4322/acr.2018.092 DB - PRIME DP - Unbound Medicine ER -
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