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Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst.
Clin Pathol 2019 Jan-Dec; 12:2632010X19861109CP

Abstract

Fibrous dysplasia is a benign, mass-forming disease of bone composed of abnormal fibrous and osseous elements that can be accompanied by endocrine dysfunction, skin pigmentation, and intramuscular myxomas. It is usually encountered as a solitary lesion in the tibia or femur but can develop in any bone and can be unifocal or multifocal. Difficulty arises when a solitary lesion is identified in an uncommon site or when there are prominent secondary changes, such as aneurysmal bone cyst (ABC). Molecular studies are available as an adjunct to histomorphology to aid distinction from other entities. GNAS mutations, present in greater than 70% of fibrous dysplasia cases, help in the distinction from primary ABC and low-grade osteosarcoma, which exhibit different molecular abnormalities. We report a case of monostotic fibrous dysplasia in a lumbar vertebral body with secondary change consisting of the solid variant of ABC.

Authors+Show Affiliations

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31321388

Citation

Maloney, Nolan, and Konstantinos Linos. "Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst." Clinical Pathology (Thousand Oaks, Ventura County, Calif.), vol. 12, 2019, p. 2632010X19861109.
Maloney N, Linos K. Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst. Clin Pathol. 2019;12:2632010X19861109.
Maloney, N., & Linos, K. (2019). Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst. Clinical Pathology (Thousand Oaks, Ventura County, Calif.), 12, p. 2632010X19861109. doi:10.1177/2632010X19861109.
Maloney N, Linos K. Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst. Clin Pathol. 2019;12:2632010X19861109. PubMed PMID: 31321388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst. AU - Maloney,Nolan, AU - Linos,Konstantinos, Y1 - 2019/07/03/ PY - 2019/05/31/received PY - 2019/06/07/accepted PY - 2019/7/20/entrez PY - 2019/7/20/pubmed PY - 2019/7/20/medline KW - ABC KW - CDH11 KW - Fibrous dysplasia KW - GNAS KW - Mazabraud KW - McCune-Albright KW - aneurysmal bone cyst SP - 2632010X19861109 EP - 2632010X19861109 JF - Clinical pathology (Thousand Oaks, Ventura County, Calif.) JO - Clin Pathol VL - 12 N2 - Fibrous dysplasia is a benign, mass-forming disease of bone composed of abnormal fibrous and osseous elements that can be accompanied by endocrine dysfunction, skin pigmentation, and intramuscular myxomas. It is usually encountered as a solitary lesion in the tibia or femur but can develop in any bone and can be unifocal or multifocal. Difficulty arises when a solitary lesion is identified in an uncommon site or when there are prominent secondary changes, such as aneurysmal bone cyst (ABC). Molecular studies are available as an adjunct to histomorphology to aid distinction from other entities. GNAS mutations, present in greater than 70% of fibrous dysplasia cases, help in the distinction from primary ABC and low-grade osteosarcoma, which exhibit different molecular abnormalities. We report a case of monostotic fibrous dysplasia in a lumbar vertebral body with secondary change consisting of the solid variant of ABC. SN - 2632-010X UR - https://www.unboundmedicine.com/medline/citation/31321388/Monostotic_Fibrous_Dysplasia_of_the_Lumbar_Spine_With_Secondary_Features_of_Solid_Variant_Aneurysmal_Bone_Cyst L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31321388/ DB - PRIME DP - Unbound Medicine ER -