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MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO AND RIEDEL'S THYROIDITIS.
Georgian Med News. 2019 MayGM

Abstract

Investigated 62 sample of thyroid gland obtained after surgical intervention, including: HT (n=27), RT (n=9), Graves' disease (n=17) and papillary thyroid carcinoma (n = 10). The slides were studied using classical histological and immunohistochemical methods: H&E, TTF1, TSH, S100-protein, CD56 and p63. Dispite of the histological and immunohistochemical heterogeneity of Thyroiditis HT and RT, the progressive involution of the glandular tissue with the replacement by the sever fibrosis, in some cases by the scar tissue is observed as damage sign. In Hashimoto thyroiditis, the foci of follicular epithelium dysplasia were determined, with p63 positive and CD56 negative reactions. Graves' disease is characterized by high TSH expression as well as lymphoproliferation with the formation of large fused nodules with germinative centers. With Riedel's thyroiditis, there is a moderate expression of TTF-1 in the stroma and capillary endotheliocytes, as well as diffuse-focal moderate expression of S100 protein in cells of neuroectodermal population. The reaction to malignant transformation markers - CD56 and p63 - in the tissue of Thyroid gland with Thyroiditis, Riedel was definitely negative.

Authors+Show Affiliations

1Ivane Javakhishvili Tbilisi State University.1Ivane Javakhishvili Tbilisi State University.2Akaki Tsereteli Kutaisi State University, Georgia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31322526

Citation

Gvianishvili, T, et al. "MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO and RIEDEL'S THYROIDITIS." Georgian Medical News, 2019, pp. 116-120.
Gvianishvili T, Gogiashvili L, Chkhobadze M. MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO AND RIEDEL'S THYROIDITIS. Georgian Med News. 2019.
Gvianishvili, T., Gogiashvili, L., & Chkhobadze, M. (2019). MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO AND RIEDEL'S THYROIDITIS. Georgian Medical News, (290), 116-120.
Gvianishvili T, Gogiashvili L, Chkhobadze M. MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO and RIEDEL'S THYROIDITIS. Georgian Med News. 2019;(290)116-120. PubMed PMID: 31322526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MOLECULAR-BIOLOGICAL THYROID PROFILE DURING AUTOIMMUNE DISEASE - HASHIMOTO AND RIEDEL'S THYROIDITIS. AU - Gvianishvili,T, AU - Gogiashvili,L, AU - Chkhobadze,M, PY - 2019/7/20/entrez PY - 2019/7/20/pubmed PY - 2019/10/30/medline SP - 116 EP - 120 JF - Georgian medical news JO - Georgian Med News IS - 290 N2 - Investigated 62 sample of thyroid gland obtained after surgical intervention, including: HT (n=27), RT (n=9), Graves' disease (n=17) and papillary thyroid carcinoma (n = 10). The slides were studied using classical histological and immunohistochemical methods: H&E, TTF1, TSH, S100-protein, CD56 and p63. Dispite of the histological and immunohistochemical heterogeneity of Thyroiditis HT and RT, the progressive involution of the glandular tissue with the replacement by the sever fibrosis, in some cases by the scar tissue is observed as damage sign. In Hashimoto thyroiditis, the foci of follicular epithelium dysplasia were determined, with p63 positive and CD56 negative reactions. Graves' disease is characterized by high TSH expression as well as lymphoproliferation with the formation of large fused nodules with germinative centers. With Riedel's thyroiditis, there is a moderate expression of TTF-1 in the stroma and capillary endotheliocytes, as well as diffuse-focal moderate expression of S100 protein in cells of neuroectodermal population. The reaction to malignant transformation markers - CD56 and p63 - in the tissue of Thyroid gland with Thyroiditis, Riedel was definitely negative. SN - 1512-0112 UR - https://www.unboundmedicine.com/medline/citation/31322526/MOLECULAR-BIOLOGICAL_THYROID_PROFILE_DURING_AUTOIMMUNE_DISEASE_-_HASHIMOTO_AND_RIEDEL'S_THYROIDITIS L2 - http://www.diseaseinfosearch.org/result/3247 DB - PRIME DP - Unbound Medicine ER -