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Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation.

Abstract

Prospective studies concerning sleep architecture and cognitive function have focused on individual sleep measures per se, without considering the complementary role of non-REM (NREM) and REM sleep. We explored the association between NREM/REM cycle-related sleep architecture and cognitive decline. Community-dwelling elderly people in Korea from the Korean Longitudinal Study on Cognitive Aging and Dementia were enrolled. They were cognitively normal and underwent an overnight polysomnography at baseline. A NREM/REM cycle is a sequence of NREM and REM sleep, uninterrupted by a waking period of >2 min. After 4 years, the development of mild cognitive impairment (MCI) or dementia was related to the measures of sleep architecture, including NREM/REM cycle parameters by logistic regression analyses. Of 235 participants (mean [SD] age 68 [5] years; 60% female) at baseline, 14 (5.9%) developed MCI/dementia at follow-up. A short average cycle length (OR, 0.97 [95% CI, 0.94-0.99]; p = 0.02) was significantly associated with cognitive decline. When its substructure and NREM and REM sleep outside of cycles were considered simultaneously, the average REM sleep duration per cycle (OR, 0.87 [95% CI, 0.76-0.98]; p = 0.03) was significantly related to the outcome. In conclusion, a short average duration of NREM/REM cycles, especially average REM sleep duration in each cycle, in cognitively normal elderly might be used as an early marker of cognitive decline.

Authors+Show Affiliations

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Psychiatry, Dongguk University Gyeongju Hospital, Gyeongju, Korea.Department of Psychiatry, Gyeongsang National University School of Medicine, Jinju, Korea.Department of Neuropsychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea.Department of Psychiatry, Yonsei University Wonju Severance Christian Hospital, Wonju, Korea.Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Medical Center, Seoul, Korea.Department of Psychiatry, School of Medicine, Konkuk University, Konkuk University Chungju Hospital, Chungju, Korea.Department of Neuropsychiatry, Jeju National University Hospital, Jeju, Korea.Department of Psychiatry, Gyeongsang National University Hospital, Jinju, Korea.Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Korea.Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.Department of Neuropsychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea.Department of Psychiatry, Dankook University Hospital, Cheonan, Korea.Department of Psychiatry, Dankook University Hospital, Cheonan, Korea.Department of Psychiatry, Kangwon National University, School of Medicine, Chuncheon, Korea.Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea.Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea. Department of Psychiatry, Seoul National University, College of Medicine, Seoul, Korea. Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, Korea. National Institute of Dementia, Seongnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31322573

Citation

Suh, Seung Wan, et al. "Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: an Exploratory Investigation." Journal of Alzheimer's Disease : JAD, 2019.
Suh SW, Han JW, Lee JR, et al. Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation. J Alzheimers Dis. 2019.
Suh, S. W., Han, J. W., Lee, J. R., Byun, S., Kwak, K. P., Kim, B. J., ... Kim, K. W. (2019). Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation. Journal of Alzheimer's Disease : JAD, doi:10.3233/JAD-190399.
Suh SW, et al. Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: an Exploratory Investigation. J Alzheimers Dis. 2019 Jul 15; PubMed PMID: 31322573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short Average Duration of NREM/REM Cycle Is Related to Cognitive Decline in an Elderly Cohort: An Exploratory Investigation. AU - Suh,Seung Wan, AU - Han,Ji Won, AU - Lee,Ju Ri, AU - Byun,Seonjeong, AU - Kwak,Kyung Phil, AU - Kim,Bong-Jo, AU - Kim,Shin Gyeom, AU - Kim,Jeong Lan, AU - Kim,Tae Hui, AU - Ryu,Seung-Ho, AU - Moon,Seok Woo, AU - Park,Joon Hyuk, AU - Seo,Jiyeong, AU - Youn,Jong Chul, AU - Lee,Dong Young, AU - Lee,Dong Woo, AU - Lee,Seok Bum, AU - Lee,Jung Jae, AU - Jhoo,Jin Hyeong, AU - Yoon,In Young, AU - Kim,Ki Woong, Y1 - 2019/07/15/ PY - 2019/7/20/entrez KW - Dementia KW - mild cognitive impairment KW - sequential hypothesis KW - sleep JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. N2 - Prospective studies concerning sleep architecture and cognitive function have focused on individual sleep measures per se, without considering the complementary role of non-REM (NREM) and REM sleep. We explored the association between NREM/REM cycle-related sleep architecture and cognitive decline. Community-dwelling elderly people in Korea from the Korean Longitudinal Study on Cognitive Aging and Dementia were enrolled. They were cognitively normal and underwent an overnight polysomnography at baseline. A NREM/REM cycle is a sequence of NREM and REM sleep, uninterrupted by a waking period of >2 min. After 4 years, the development of mild cognitive impairment (MCI) or dementia was related to the measures of sleep architecture, including NREM/REM cycle parameters by logistic regression analyses. Of 235 participants (mean [SD] age 68 [5] years; 60% female) at baseline, 14 (5.9%) developed MCI/dementia at follow-up. A short average cycle length (OR, 0.97 [95% CI, 0.94-0.99]; p = 0.02) was significantly associated with cognitive decline. When its substructure and NREM and REM sleep outside of cycles were considered simultaneously, the average REM sleep duration per cycle (OR, 0.87 [95% CI, 0.76-0.98]; p = 0.03) was significantly related to the outcome. In conclusion, a short average duration of NREM/REM cycles, especially average REM sleep duration in each cycle, in cognitively normal elderly might be used as an early marker of cognitive decline. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/31322573/Short_Average_Duration_of_NREM/REM_Cycle_Is_Related_to_Cognitive_Decline_in_an_Elderly_Cohort:_An_Exploratory_Investigation L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-190399 DB - PRIME DP - Unbound Medicine ER -