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Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations.

Abstract

Background The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions), even considering the altitude (lowland <2500 m and highland >2500 m). Methods The polymorphism was analyzed by TaqMan genotyping assays in a group of 181 healthy unrelated Peruvian individuals. The comparison of genotype and allele frequencies of 3435C>T polymorphism was made with the Pearson test (X2), and, to calculate the genotype distributions, the Hardy-Weinberg equilibrium (HWE) was used. Results In all populations evaluated in this study, the genotype frequency distributions met HWE assumptions. The comparison between genotype and allele frequencies showed significant differences (p < 0.05), when the Andean, Coastal and Amazonian populations were compared. Also, significant differences (p < 0.05) were obtained when these populations were compared considering their altitudes. Likewise, in comparison with countries like USA, Finland, Nigeria and Kenya, the results showed significant differences (p < 0.05). Conclusions This investigation allowed us to establish the genotype and allele frequencies of 3435C>T polymorphism in different Peruvian populations, considering the geographic localization and even the altitude.

Authors+Show Affiliations

Universidad de San Martin de Porres, Facultad de Medicina Humana, Instituto de Investigación, Centro de Investigación en Infectología e Inmunología, Centro de Investigación de Medicina Tradicional y Farmacología, Avenida El Corregidor N°1531, Las Viñas, La Molina, Lima, Peru.Universidad Peruana Unión, Universidad de San Martin de Porres, Escuela Profesional de Medicina Humana, Laboratorio de Investigación en Biología Molecular, Facultad de Medicina Humana, Instituto de Investigación, Centro de Investigación de Medicina de Altura, Centro de Investigación de Medicina Tradicional y Farmacología, Km 19 Carretera Central, Ñaña, Lurigancho, Avenida El Corregidor N°1531, Las Viñas, La Molina Lima, Peru.Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Clinica Médica, Laboratório de Hipertensao Expermental e Farmacogenetica, Av. Bandeirantes, 3900 - Vila Monte Alegre, Ribeirão Preto - SP, 14049-900 São Paulo, Brazil.Universidad de San Martin de Porres, Facultad de Medicina Humana, Instituto de Investigación, Centro de Investigación de Genética y Biología Molecular, Avenida El Corregidor N°1531, Las Viñas, La Molina Lima, Peru.Universidad de San Martin de Porres, Facultad de Medicina Humana, Instituto de Investigación, Centro de Investigación de Medicina de Altura, Centro de Investigación de Medicina Tradicional y Farmacología, Av. Alameda del Corregidor 1531, La Molina, Lima CP 15026, Peru, Phone: (051) (01) 3652300 extension 151.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31323002

Citation

Valencia Ayala, Edward, et al. "Geographic Distribution of the 3435C>T Polymorphism of the MDR1 Gene in Peruvian Populations." Drug Metabolism and Personalized Therapy, 2019.
Valencia Ayala E, Marcos Carbajal P, Coelho EB, et al. Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations. Drug Metab Pers Ther. 2019.
Valencia Ayala, E., Marcos Carbajal, P., Coelho, E. B., Sandoval, J. S., & Salazar Granara, A. (2019). Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations. Drug Metabolism and Personalized Therapy, doi:10.1515/dmpt-2018-0041.
Valencia Ayala E, et al. Geographic Distribution of the 3435C>T Polymorphism of the MDR1 Gene in Peruvian Populations. Drug Metab Pers Ther. 2019 Jul 19; PubMed PMID: 31323002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geographic distribution of the 3435C>T polymorphism of the MDR1 gene in Peruvian populations. AU - Valencia Ayala,Edward, AU - Marcos Carbajal,Pool, AU - Coelho,Eduardo Barbosa, AU - Sandoval,Jose Sandoval, AU - Salazar Granara,Alberto, Y1 - 2019/07/19/ PY - 2018/12/08/received PY - 2019/05/20/accepted PY - 2019/7/20/pubmed PY - 2019/7/20/medline PY - 2019/7/20/entrez KW - ethnic population KW - gene polymorphism KW - genotyping KW - pharmacokinetics JF - Drug metabolism and personalized therapy JO - Drug Metab Pers Ther N2 - Background The MDR1 gene presents several genetic polymorphisms with pharmacological implications. Therefore, the aim of the present study is to establish the genotype and allele frequencies of 3435C>T polymorphism of MDR1 gene into Peruvian populations (Coastal, Andean and Amazonian ecoregions), even considering the altitude (lowland <2500 m and highland >2500 m). Methods The polymorphism was analyzed by TaqMan genotyping assays in a group of 181 healthy unrelated Peruvian individuals. The comparison of genotype and allele frequencies of 3435C>T polymorphism was made with the Pearson test (X2), and, to calculate the genotype distributions, the Hardy-Weinberg equilibrium (HWE) was used. Results In all populations evaluated in this study, the genotype frequency distributions met HWE assumptions. The comparison between genotype and allele frequencies showed significant differences (p < 0.05), when the Andean, Coastal and Amazonian populations were compared. Also, significant differences (p < 0.05) were obtained when these populations were compared considering their altitudes. Likewise, in comparison with countries like USA, Finland, Nigeria and Kenya, the results showed significant differences (p < 0.05). Conclusions This investigation allowed us to establish the genotype and allele frequencies of 3435C>T polymorphism in different Peruvian populations, considering the geographic localization and even the altitude. SN - 2363-8915 UR - https://www.unboundmedicine.com/medline/citation/31323002/Geographic_distribution_of_the_3435C>T_polymorphism_of_the_MDR1_gene_in_Peruvian_populations L2 - https://www.degruyter.com/doi/10.1515/dmpt-2018-0041 DB - PRIME DP - Unbound Medicine ER -