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Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity.

Abstract

Background Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity. Methods Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. FGF21 rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group. Results The T allele of rs11665896 in the FGF21 gene was associated with obesity (odds ratio [OR] = 1.99, 95% confidence interval [CI] = 1.14-3.46; p = 0.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r = -0.232, p = 0.022) and positively with body weight (r = 0.269, p = 0.007), waist (r = 0.242, p = 0.016) and hip girth (r = 0.204, p = 0.042). FGF21 levels were lower in carriers of at least one T allele. Conclusions Genetic variants in FGF21 could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children.

Authors+Show Affiliations

Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico.Department of Planning Subdirection, General Hospital of Leon, León, Gto, Mexico.Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico.Department of Pharmacy, Natural and Exact Sciences Division, University of Guanajuato, Guanajuato Campus, Guanajuato, Gto, Mexico.Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico.Department of Medicine and Nutrition, Health Sciences Division, University of Guanajuato, Leon Campus, León, Gto, Mexico.Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico.Department of Medical Sciences, Health Sciences Division, University of Guanajuato, Leon Campus, León, Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31323006

Citation

Ruiz-Padilla, Alan Joel, et al. "Association of the 3'UTR Polymorphism (rs11665896) in the FGF21 Gene With Metabolic Status and Nutrient Intake in Children With Obesity." Journal of Pediatric Endocrinology & Metabolism : JPEM, 2019.
Ruiz-Padilla AJ, Morales-Hernandez G, Ruiz-Noa Y, et al. Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity. J Pediatr Endocrinol Metab. 2019.
Ruiz-Padilla, A. J., Morales-Hernandez, G., Ruiz-Noa, Y., Alonso-Castro, A. J., Lazo-de-la-Vega-Monroy, M. L., Preciado-Puga, M. D. C., ... Ibarra-Reynoso, L. D. R. (2019). Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity. Journal of Pediatric Endocrinology & Metabolism : JPEM, doi:10.1515/jpem-2018-0546.
Ruiz-Padilla AJ, et al. Association of the 3'UTR Polymorphism (rs11665896) in the FGF21 Gene With Metabolic Status and Nutrient Intake in Children With Obesity. J Pediatr Endocrinol Metab. 2019 Jul 16; PubMed PMID: 31323006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the 3'UTR polymorphism (rs11665896) in the FGF21 gene with metabolic status and nutrient intake in children with obesity. AU - Ruiz-Padilla,Alan Joel, AU - Morales-Hernandez,Gerardo, AU - Ruiz-Noa,Yeniley, AU - Alonso-Castro,Angel Josabad, AU - Lazo-de-la-Vega-Monroy,Maria Luisa, AU - Preciado-Puga,Monica Del Carmen, AU - Rangel-Salazar,Ruben, AU - Ibarra-Reynoso,Lorena Del Rocio, Y1 - 2019/07/16/ PY - 2018/12/10/received PY - 2019/05/18/accepted PY - 2019/7/20/pubmed PY - 2019/7/20/medline PY - 2019/7/20/entrez KW - FGF21 KW - genetic variants KW - nutrient intake KW - obesity JF - Journal of pediatric endocrinology & metabolism : JPEM JO - J. Pediatr. Endocrinol. Metab. N2 - Background Fibroblast growth factor 21 (FGF21) is considered an important regulator of lipid and glucose metabolism. However, the role of FGF21 in macronutrient intake and metabolic disease, particularly in pediatric population, still needs further clarification. This study aimed to evaluate the association of rs11665896 in the FGF21 gene with metabolic status and macronutrient intake in a cohort of Mexican children with obesity. Methods Eighty-four lean children and 113 children with obesity, from 8 to 11 years of age, were recruited. FGF21 rs11665896 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Somatometric evaluations, nutrient intake, glucose, lipids, insulin and FGF21 serum levels were measured in the obesity group. Results The T allele of rs11665896 in the FGF21 gene was associated with obesity (odds ratio [OR] = 1.99, 95% confidence interval [CI] = 1.14-3.46; p = 0.0151). Subjects with obesity carrying the TT genotype consumed less lipids and more carbohydrates compared to other genotypes. Circulating FGF21 levels correlated negatively with carbohydrate intake (r = -0.232, p = 0.022) and positively with body weight (r = 0.269, p = 0.007), waist (r = 0.242, p = 0.016) and hip girth (r = 0.204, p = 0.042). FGF21 levels were lower in carriers of at least one T allele. Conclusions Genetic variants in FGF21 could influence metabolic status, food preferences and qualitative changes in nutritional behavior in children. SN - 2191-0251 UR - https://www.unboundmedicine.com/medline/citation/31323006/Association_of_the_3'UTR_polymorphism_(rs11665896)_in_the_FGF21_gene_with_metabolic_status_and_nutrient_intake_in_children_with_obesity L2 - https://www.degruyter.com/doi/10.1515/jpem-2018-0546 DB - PRIME DP - Unbound Medicine ER -