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Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China.
PLoS One 2019; 14(7):e0217607Plos

Abstract

Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), an active surveillance program has been conducted from 2013 to 2015 in Guangdong, China. The phylogenetic analyses showed that the external genes of the isolates were assigned to the Eurasian avian-like swine (EA) H1N1 and/or human-like H3N2 lineages with multiple substitutions, indicating a notable genetic shift. Moreover, the internal genes derived from different origins (PB2, PB1, PA, NP: pdm/09 (pandemic influenza virus 2009)-origin, M: pdm/09- or EA-origin, NS: North American Triple Reassortant (TR)-origin have become the dominant backbone of IAV-S in southern China. According to the origins of the eight gene segments, the isolates can be categorized into five genotypes. The results of mice experiment showed that the YJ4 (genotype 1) and DG2 (genotype 4) are the most pathogenic to mice, and the viruses are observed in kidneys and brains, indicating the systemic infection. The alterations of the IAV-S gene composition supported the continued implementation of the intensive surveillance of IAV-S and the greater attention focused on potential shifts toward transmission to humans.

Authors+Show Affiliations

College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. National Engineering Research Center for Breeding Swine Industry, Guangzhou, China. Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. National Engineering Research Center for Breeding Swine Industry, Guangzhou, China. Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. National Engineering Research Center for Breeding Swine Industry, Guangzhou, China. Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. National Engineering Research Center for Breeding Swine Industry, Guangzhou, China. Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31323023

Citation

Cao, Zhenpeng, et al. "Continuous Evolution of Influenza a Viruses of Swine From 2013 to 2015 in Guangdong, China." PloS One, vol. 14, no. 7, 2019, pp. e0217607.
Cao Z, Zeng W, Hao X, et al. Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China. PLoS ONE. 2019;14(7):e0217607.
Cao, Z., Zeng, W., Hao, X., Huang, J., Cai, M., Zhou, P., & Zhang, G. (2019). Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China. PloS One, 14(7), pp. e0217607. doi:10.1371/journal.pone.0217607.
Cao Z, et al. Continuous Evolution of Influenza a Viruses of Swine From 2013 to 2015 in Guangdong, China. PLoS ONE. 2019;14(7):e0217607. PubMed PMID: 31323023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous evolution of influenza A viruses of swine from 2013 to 2015 in Guangdong, China. AU - Cao,Zhenpeng, AU - Zeng,Weijie, AU - Hao,Xiangqi, AU - Huang,Junming, AU - Cai,Mengkai, AU - Zhou,Pei, AU - Zhang,Guihong, Y1 - 2019/07/19/ PY - 2019/03/14/received PY - 2019/05/16/accepted PY - 2019/7/20/entrez PY - 2019/7/20/pubmed PY - 2019/7/20/medline SP - e0217607 EP - e0217607 JF - PloS one JO - PLoS ONE VL - 14 IS - 7 N2 - Southern China is considered an important source of influenza virus pandemics because of the large, diverse viral reservoirs in poultry and swine. To examine the trend in influenza A virus of swine (IAV-S), an active surveillance program has been conducted from 2013 to 2015 in Guangdong, China. The phylogenetic analyses showed that the external genes of the isolates were assigned to the Eurasian avian-like swine (EA) H1N1 and/or human-like H3N2 lineages with multiple substitutions, indicating a notable genetic shift. Moreover, the internal genes derived from different origins (PB2, PB1, PA, NP: pdm/09 (pandemic influenza virus 2009)-origin, M: pdm/09- or EA-origin, NS: North American Triple Reassortant (TR)-origin have become the dominant backbone of IAV-S in southern China. According to the origins of the eight gene segments, the isolates can be categorized into five genotypes. The results of mice experiment showed that the YJ4 (genotype 1) and DG2 (genotype 4) are the most pathogenic to mice, and the viruses are observed in kidneys and brains, indicating the systemic infection. The alterations of the IAV-S gene composition supported the continued implementation of the intensive surveillance of IAV-S and the greater attention focused on potential shifts toward transmission to humans. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/31323023/Continuous_evolution_of_influenza_A_viruses_of_swine_from_2013_to_2015_in_Guangdong,_China L2 - http://dx.plos.org/10.1371/journal.pone.0217607 DB - PRIME DP - Unbound Medicine ER -