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Antiphospholipid syndrome's genetic and epigenetic aspects.
Autoimmun Rev 2019; :102352AR

Abstract

Studies on last genetic and epigenetic predisposition to APS are summarized. It is well known that genetic predisposition is in HLA system (DR4 and DRw53) and that lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are both associated with the same HLA antigens. Other genes, outside the MHC, give their contribution to the development of this autoimmune syndrome, such as IRF5, STAT4 and those related to inherited thrombophilia - factor V Leiden and G20210A prothrombin polymorphisms. Finally, post-transcriptional modifications of anti-beta2GPI antibodies could be implicated too. The most important discovery of last years is that altered microRNAs' expression is linked to autoimmunity, thrombosis, early atherosclerosis, and oxidative stress in APS.

Authors+Show Affiliations

Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy.Rheumatology Institute, University of Siena, Italy.Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy. Electronic address: gsebastiani@scamilloforlanini.rm.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31323355

Citation

Iuliano, Annamaria, et al. "Antiphospholipid Syndrome's Genetic and Epigenetic Aspects." Autoimmunity Reviews, 2019, p. 102352.
Iuliano A, Galeazzi M, Sebastiani GD. Antiphospholipid syndrome's genetic and epigenetic aspects. Autoimmun Rev. 2019.
Iuliano, A., Galeazzi, M., & Sebastiani, G. D. (2019). Antiphospholipid syndrome's genetic and epigenetic aspects. Autoimmunity Reviews, p. 102352. doi:10.1016/j.autrev.2019.102352.
Iuliano A, Galeazzi M, Sebastiani GD. Antiphospholipid Syndrome's Genetic and Epigenetic Aspects. Autoimmun Rev. 2019 Jul 16;102352. PubMed PMID: 31323355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiphospholipid syndrome's genetic and epigenetic aspects. AU - Iuliano,Annamaria, AU - Galeazzi,Mauro, AU - Sebastiani,Gian Domenico, Y1 - 2019/07/16/ PY - 2019/03/20/received PY - 2019/03/26/accepted PY - 2019/7/20/pubmed PY - 2019/7/20/medline PY - 2019/7/20/entrez KW - Anti-beta2glycoprotein I antibodies KW - Anticardiolipin antibodies KW - Antiphospholipid syndrome KW - HLA KW - Lupus anticoagulant KW - MHC KW - Thrombofilic hereditary factors KW - microRNA SP - 102352 EP - 102352 JF - Autoimmunity reviews JO - Autoimmun Rev N2 - Studies on last genetic and epigenetic predisposition to APS are summarized. It is well known that genetic predisposition is in HLA system (DR4 and DRw53) and that lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are both associated with the same HLA antigens. Other genes, outside the MHC, give their contribution to the development of this autoimmune syndrome, such as IRF5, STAT4 and those related to inherited thrombophilia - factor V Leiden and G20210A prothrombin polymorphisms. Finally, post-transcriptional modifications of anti-beta2GPI antibodies could be implicated too. The most important discovery of last years is that altered microRNAs' expression is linked to autoimmunity, thrombosis, early atherosclerosis, and oxidative stress in APS. SN - 1873-0183 UR - https://www.unboundmedicine.com/medline/citation/31323355/Antiphospholipid_syndrome's_genetic_and_epigenetic_aspects L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-9972(19)30152-1 DB - PRIME DP - Unbound Medicine ER -