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Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial.

Abstract

White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss.

Authors+Show Affiliations

Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia. Electronic address: venkatraman.vk@gmail.com.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.Medical School, University of Western Australia, Perth, Australia.Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia; Melbourne EpiCenter, Royal Melbourne Hospital, Melbourne, Australia.School of Health Sciences, University of Tasmania, Launceston, Australia.Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia; National Ageing Research Institute, Melbourne, Victoria, Australia.National Ageing Research Institute, Melbourne, Victoria, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia; National Ageing Research Institute, Melbourne, Victoria, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.Department of Molecular Imaging & Therapy, Austin Health, Melbourne, Australia; Melbourne Dementia Research Centre, University of Melbourne, Melbourne, Australia.The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia.Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Melbourne, Australia; NorthWestern Mental Health, Melbourne Health, Melbourne, Victoria, Australia.Department of Medicine and Radiology, The University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31324405

Citation

Venkatraman, Vijay K., et al. "Effect of a 24-month Physical Activity Program On Brain Changes in Older Adults at Risk of Alzheimer's Disease: the AIBL Active Trial." Neurobiology of Aging, 2019.
Venkatraman VK, Sanderson A, Cox KL, et al. Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial. Neurobiol Aging. 2019.
Venkatraman, V. K., Sanderson, A., Cox, K. L., Ellis, K. A., Steward, C., Phal, P. M., ... Desmond, P. M. (2019). Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial. Neurobiology of Aging, doi:10.1016/j.neurobiolaging.2019.02.030.
Venkatraman VK, et al. Effect of a 24-month Physical Activity Program On Brain Changes in Older Adults at Risk of Alzheimer's Disease: the AIBL Active Trial. Neurobiol Aging. 2019 May 27; PubMed PMID: 31324405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a 24-month physical activity program on brain changes in older adults at risk of Alzheimer's disease: the AIBL active trial. AU - Venkatraman,Vijay K, AU - Sanderson,Andrew, AU - Cox,Kay L, AU - Ellis,Kathryn A, AU - Steward,Christopher, AU - Phal,Pramit M, AU - Gorelik,Alexandra, AU - Sharman,Matthew J, AU - Villemagne,Victor L, AU - Lai,Michelle, AU - Cyarto,Elizabeth V, AU - Merkel,Bernd, AU - Ames,David, AU - Szoeke,Cassandra, AU - Rowe,Christopher C, AU - Masters,Colin L, AU - Lautenschlager,Nicola T, AU - Desmond,Patricia M, Y1 - 2019/05/27/ PY - 2018/01/02/received PY - 2019/01/30/revised PY - 2019/02/03/accepted PY - 2019/7/21/entrez PY - 2019/7/22/pubmed PY - 2019/7/22/medline KW - Cognitive impairment KW - Hippocampal loss KW - Intervention KW - Physical activity KW - White matter hyperintensity JF - Neurobiology of aging JO - Neurobiol. Aging N2 - White matter hyperintensities (WMHs) are a risk factor for cognitive decline. Physical activity (PA) is associated with lower WMH. Whether long-term exposure to PA programs has beneficial effects on WMH progression in older adults with memory complaints and comorbid conditions has had limited exploration. This study explored whether a 24-month moderate-intensity PA intervention can delay the progression of WMH and hippocampus loss in older adults at risk for cognitive decline. Data acquired on magnetic resonance imaging were used to measure the progression of WMH and hippocampus loss. The results of this study showed no effect of intervention on either the primary outcome measure "WMH" or the secondary outcome measure "hippocampal volume." In addition, neither beta amyloid status nor the adherence to the intervention had any effect on the outcome. In this cohort of subjective memory complaints and mild cognitive impairment participants with vascular risk factors, there was no effect of long-term moderate-intensity PA on WMH or hippocampal loss. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/31324405/Effect_of_a_24_month_physical_activity_program_on_brain_changes_in_older_adults_at_risk_of_Alzheimer's_disease:_the_AIBL_active_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(19)30155-1 DB - PRIME DP - Unbound Medicine ER -