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Specific inter-stimulus interval effect of NMDA receptor activation in the insular cortex during conditioned taste aversion.
Neurobiol Learn Mem. 2019 10; 164:107043.NL

Abstract

Taste memory recognition is crucial for species survival; thus, the acquisition of conditioned taste aversion (CTA) protects animals against consuming poisons or toxins. In nature, food and poison are confined in the same edible item; however, in the laboratory these food constituents are usually presented separately for experimental analysis. The taste, or conditioned stimulus (CS), can be hours apart from the gastric malaise, or unconditioned stimulus (US); this extended inter-stimulus interval (ISI) allows the analysis of a particular learning phase. Evidence indicates a relevant function of glutamatergic activity in the insular cortex (IC) throughout the ISI. N-methyl-D-aspartate receptors (NMDAR) are crucial during CTA acquisition and retrieval. However, the exact participation of NMDAR in the IC during the ISI has not been demonstrated. Thus, the aim of this work was to evaluate the effects of temporal NMDAR activation during four time frames throughout the ISI of conditioned sugar aversion with bilateral injections of NMDA at a physiological dose (1 µg/µl) in the IC, given (1) immediately before or (2) immediately after sugar presentation, or (3) immediately before or (4) immediately after LiCl i.p. injection. The results showed that NMDAR activation in the IC had a specific ISI effect during CTA acquisition, increasing aversive memory formation and delaying extinction only after CS presentation. Overall, these results demonstrate that NMDAR in the IC have a particular enhancing associative effect after CS and suggest that there is a precise coincidence in neurochemical events in the IC that correlates with the stimulus to be associated and the glutamate NMDAR activity that must be finely tuned in the ISI during CTA acquisition.

Authors+Show Affiliations

Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro 76230, Mexico.Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus Juriquilla, Querétaro 76230, Mexico. Electronic address: mirandami@unam.mx.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31325496

Citation

Olvera, María-José, and María-Isabel Miranda. "Specific Inter-stimulus Interval Effect of NMDA Receptor Activation in the Insular Cortex During Conditioned Taste Aversion." Neurobiology of Learning and Memory, vol. 164, 2019, p. 107043.
Olvera MJ, Miranda MI. Specific inter-stimulus interval effect of NMDA receptor activation in the insular cortex during conditioned taste aversion. Neurobiol Learn Mem. 2019;164:107043.
Olvera, M. J., & Miranda, M. I. (2019). Specific inter-stimulus interval effect of NMDA receptor activation in the insular cortex during conditioned taste aversion. Neurobiology of Learning and Memory, 164, 107043. https://doi.org/10.1016/j.nlm.2019.107043
Olvera MJ, Miranda MI. Specific Inter-stimulus Interval Effect of NMDA Receptor Activation in the Insular Cortex During Conditioned Taste Aversion. Neurobiol Learn Mem. 2019;164:107043. PubMed PMID: 31325496.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific inter-stimulus interval effect of NMDA receptor activation in the insular cortex during conditioned taste aversion. AU - Olvera,María-José, AU - Miranda,María-Isabel, Y1 - 2019/07/17/ PY - 2019/02/28/received PY - 2019/05/30/revised PY - 2019/07/10/accepted PY - 2019/7/22/pubmed PY - 2020/4/9/medline PY - 2019/7/21/entrez KW - Conditioning KW - Extinction KW - Glutamate KW - Long-term memory KW - Sugar SP - 107043 EP - 107043 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 164 N2 - Taste memory recognition is crucial for species survival; thus, the acquisition of conditioned taste aversion (CTA) protects animals against consuming poisons or toxins. In nature, food and poison are confined in the same edible item; however, in the laboratory these food constituents are usually presented separately for experimental analysis. The taste, or conditioned stimulus (CS), can be hours apart from the gastric malaise, or unconditioned stimulus (US); this extended inter-stimulus interval (ISI) allows the analysis of a particular learning phase. Evidence indicates a relevant function of glutamatergic activity in the insular cortex (IC) throughout the ISI. N-methyl-D-aspartate receptors (NMDAR) are crucial during CTA acquisition and retrieval. However, the exact participation of NMDAR in the IC during the ISI has not been demonstrated. Thus, the aim of this work was to evaluate the effects of temporal NMDAR activation during four time frames throughout the ISI of conditioned sugar aversion with bilateral injections of NMDA at a physiological dose (1 µg/µl) in the IC, given (1) immediately before or (2) immediately after sugar presentation, or (3) immediately before or (4) immediately after LiCl i.p. injection. The results showed that NMDAR activation in the IC had a specific ISI effect during CTA acquisition, increasing aversive memory formation and delaying extinction only after CS presentation. Overall, these results demonstrate that NMDAR in the IC have a particular enhancing associative effect after CS and suggest that there is a precise coincidence in neurochemical events in the IC that correlates with the stimulus to be associated and the glutamate NMDAR activity that must be finely tuned in the ISI during CTA acquisition. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/31325496/Specific_inter-stimulus_interval_effect_of_NMDA_receptor_activation_in_the_insular_cortex_during_conditioned_taste_aversion L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(19)30110-8 DB - PRIME DP - Unbound Medicine ER -