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Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study.
J Ethnopharmacol 2019; 243:112091JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Polycystic ovary syndrome (PCOS) is a common condition that affects 5%-10% of women of reproductive age worldwide. Patients with PCOS have a high degree of insulin resistance and are at an increased risk of developing type 2 diabetes mellitus (T2DM). The currently available therapeutic approaches for PCOS mainly focus on symptomatic treatment.

AIM OF THE STUDY

This study aimed to determine whether Chinese herbal medicine (CMH)-based interventions could reduce the risk of T2DM in PCOS patients.

MATERIALS AND METHODS

This retrospective study randomly selected 1 million enrollees from the National Health Insurance Database and identified 3797 patients who were newly diagnosed with PCOS in 1997-2010. After 1:1 frequency-matched by age, diagnosis of PCOS year and index days, we selected 342 eligible patients in each group.

RESULTS

The incidence of T2DM in the CHM group was significantly lower than that in the non-CHM group (hazard ratio = 0.31; 95% confidence interval, 0.15-0.64; p = 0.0014) after a mean follow-up period of 5.2 years (4.20 years for the comparison cohort). Five herbal formulas and two single herbs showed protective effects, and Paeonia lactiflora was a common ingredient in the five formulas.

CONCLUSIONS

Thus, CHM may help prevent T2DM-related complications in patients with PCOS. Further clinical and pharmacological analysis based on these findings is expected in the future.

Authors+Show Affiliations

Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 404, Taiwan; Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. Electronic address: enolainsky@gmail.com.Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. Electronic address: yakultaxel@gmail.com.Research Assistant Center, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. Electronic address: lee6717kimo@yahoo.com.tw.Research Assistant Center, Show Chwan Memorial Hospital, Changhua, 500, Taiwan. Electronic address: nigel6761@gmail.com.Management Office for Health Data, China Medical University Hospital, Taichung, 404, Taiwan. Electronic address: orangechengli@gmail.com.Management Office for Health Data, China Medical University Hospital, Taichung, 404, Taiwan; College of Medicine, China Medical University, Taichung, 404, Taiwan. Electronic address: zinvii@gmail.com.Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 404, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung, 404, Taiwan; Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, 404, Taiwan; Research Center for Chinese Herbal Medicine, China Medical University, Taichung, 404, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, 404, Taiwan; Department of Biotechnology, Asia University, Taichung, 413, Taiwan. Electronic address: hungrongyen@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31325604

Citation

Liao, Wan-Ting, et al. "Integrative Chinese Herbal Medicine Therapy Reduced the Risk of Type 2 Diabetes Mellitus in Patients With Polycystic Ovary Syndrome: a Nationwide Matched Cohort Study." Journal of Ethnopharmacology, vol. 243, 2019, p. 112091.
Liao WT, Su CC, Lee MT, et al. Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study. J Ethnopharmacol. 2019;243:112091.
Liao, W. T., Su, C. C., Lee, M. T., Li, C. J., Lin, C. L., Chiang, J. H., & Yen, H. R. (2019). Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study. Journal of Ethnopharmacology, 243, p. 112091. doi:10.1016/j.jep.2019.112091.
Liao WT, et al. Integrative Chinese Herbal Medicine Therapy Reduced the Risk of Type 2 Diabetes Mellitus in Patients With Polycystic Ovary Syndrome: a Nationwide Matched Cohort Study. J Ethnopharmacol. 2019 Oct 28;243:112091. PubMed PMID: 31325604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrative Chinese herbal medicine therapy reduced the risk of type 2 diabetes mellitus in patients with polycystic ovary syndrome: A nationwide matched cohort study. AU - Liao,Wan-Ting, AU - Su,Cheng-Chiung, AU - Lee,Ming-Tsung, AU - Li,Chia-Jung, AU - Lin,Cheng-Li, AU - Chiang,Jen-Huai, AU - Yen,Hung-Rong, Y1 - 2019/07/17/ PY - 2019/02/14/received PY - 2019/07/03/revised PY - 2019/07/13/accepted PY - 2019/7/22/pubmed PY - 2019/7/22/medline PY - 2019/7/21/entrez KW - National health insurance research database KW - Polycystic ovary syndrome KW - Traditional Chinese medicine KW - Type 2 diabetes mellitus SP - 112091 EP - 112091 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 243 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Polycystic ovary syndrome (PCOS) is a common condition that affects 5%-10% of women of reproductive age worldwide. Patients with PCOS have a high degree of insulin resistance and are at an increased risk of developing type 2 diabetes mellitus (T2DM). The currently available therapeutic approaches for PCOS mainly focus on symptomatic treatment. AIM OF THE STUDY: This study aimed to determine whether Chinese herbal medicine (CMH)-based interventions could reduce the risk of T2DM in PCOS patients. MATERIALS AND METHODS: This retrospective study randomly selected 1 million enrollees from the National Health Insurance Database and identified 3797 patients who were newly diagnosed with PCOS in 1997-2010. After 1:1 frequency-matched by age, diagnosis of PCOS year and index days, we selected 342 eligible patients in each group. RESULTS: The incidence of T2DM in the CHM group was significantly lower than that in the non-CHM group (hazard ratio = 0.31; 95% confidence interval, 0.15-0.64; p = 0.0014) after a mean follow-up period of 5.2 years (4.20 years for the comparison cohort). Five herbal formulas and two single herbs showed protective effects, and Paeonia lactiflora was a common ingredient in the five formulas. CONCLUSIONS: Thus, CHM may help prevent T2DM-related complications in patients with PCOS. Further clinical and pharmacological analysis based on these findings is expected in the future. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/31325604/Integrative_Chinese_herbal_medicine_therapy_reduced_the_risk_of_type_2_diabetes_mellitus_in_patients_with_polycystic_ovary_syndrome:_A_nationwide_matched_cohort_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(19)30615-4 DB - PRIME DP - Unbound Medicine ER -