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Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review.
J Evid Based Dent Pract 2019; 19(2):166-176JE

Abstract

PURPOSE

The purpose of this study was to determine whether the adjunctive use of plasma rich in growth factors in postextraction sites could be beneficial in terms of hard- and soft-tissue healing and patients' comfort.

MATERIALS AND METHODS

An electronic search was performed on MEDLINE, EMBASE, Scopus, and CENTRAL. Only controlled clinical trials or randomized clinical trials that used plasma rich in growth factors in the test group were included. The primary outcomes were pain assessment, complications, and adverse events. Secondary outcomes were hard-tissue healing, bone remodeling, and soft-tissue healing.

RESULTS

Eight comparative studies (5 randomized clinical trials) were included. Four studies had a split-mouth design. Six hundred fourteen teeth were extracted in 338 patients. Only qualitative analysis could be performed. Postoperative pain and the incidence of complications such as alveolar osteitis were consistently lower in the test group. Hard-tissue healing, evaluated by clinical, radiographic, histologic, and histomorphometric techniques, showed significantly better results for the test group in almost all studies. Better epithelialization, keratinized tissue thickness, and healing score were also reported.

CONCLUSION

Plasma rich in growth factors may bring advantages in some relevant clinical and radiographic outcomes, such as bone density and soft-tissue healing, after tooth extraction. It could also represent a useful tool for reducing adverse events, complications, and patients' discomfort, although it is still not quantifiable.

Authors+Show Affiliations

Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italy; I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy. Electronic address: massimo.delfabbro@unimi.it.Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italy; Department of Periodontics and Oral Implantology, Institute of Dental Science and SUM Hospital, Siksha O Anusandhan, Bhubaneswar, India.Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Milano, Italy; I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31326048

Citation

Del Fabbro, Massimo, et al. "Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: a Systematic Review." The Journal of Evidence-based Dental Practice, vol. 19, no. 2, 2019, pp. 166-176.
Del Fabbro M, Panda S, Taschieri S. Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review. J Evid Based Dent Pract. 2019;19(2):166-176.
Del Fabbro, M., Panda, S., & Taschieri, S. (2019). Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review. The Journal of Evidence-based Dental Practice, 19(2), pp. 166-176. doi:10.1016/j.jebdp.2018.11.003.
Del Fabbro M, Panda S, Taschieri S. Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: a Systematic Review. J Evid Based Dent Pract. 2019;19(2):166-176. PubMed PMID: 31326048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review. AU - Del Fabbro,Massimo, AU - Panda,Sourav, AU - Taschieri,Silvio, Y1 - 2018/11/26/ PY - 2018/09/19/received PY - 2018/11/13/revised PY - 2018/11/19/accepted PY - 2019/7/22/entrez PY - 2019/7/22/pubmed PY - 2019/7/22/medline KW - Platelet rich in growth factors KW - Postextraction healing KW - Systematic review SP - 166 EP - 176 JF - The journal of evidence-based dental practice JO - J Evid Based Dent Pract VL - 19 IS - 2 N2 - PURPOSE: The purpose of this study was to determine whether the adjunctive use of plasma rich in growth factors in postextraction sites could be beneficial in terms of hard- and soft-tissue healing and patients' comfort. MATERIALS AND METHODS: An electronic search was performed on MEDLINE, EMBASE, Scopus, and CENTRAL. Only controlled clinical trials or randomized clinical trials that used plasma rich in growth factors in the test group were included. The primary outcomes were pain assessment, complications, and adverse events. Secondary outcomes were hard-tissue healing, bone remodeling, and soft-tissue healing. RESULTS: Eight comparative studies (5 randomized clinical trials) were included. Four studies had a split-mouth design. Six hundred fourteen teeth were extracted in 338 patients. Only qualitative analysis could be performed. Postoperative pain and the incidence of complications such as alveolar osteitis were consistently lower in the test group. Hard-tissue healing, evaluated by clinical, radiographic, histologic, and histomorphometric techniques, showed significantly better results for the test group in almost all studies. Better epithelialization, keratinized tissue thickness, and healing score were also reported. CONCLUSION: Plasma rich in growth factors may bring advantages in some relevant clinical and radiographic outcomes, such as bone density and soft-tissue healing, after tooth extraction. It could also represent a useful tool for reducing adverse events, complications, and patients' discomfort, although it is still not quantifiable. SN - 1532-3390 UR - https://www.unboundmedicine.com/medline/citation/31326048/Adjunctive_Use_of_Plasma_Rich_in_Growth_Factors_for_Improving_Alveolar_Socket_Healing:_A_Systematic_Review L2 - https://linkinghub.elsevier.com/retrieve/pii/S1532-3382(18)30267-7 DB - PRIME DP - Unbound Medicine ER -