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Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification.
Pathol Res Pract 2019; :152535PR

Abstract

Inflammatory myofibroblastic tumor (IMT) is a neoplastic proliferation of myofibroblastic/fibroblastic cells with a variable admixture of inflammatory cells. It primarily affects soft tissue and viscera of children and young adults. IMT occurring in bone is extremely rare. Approximately 50% of IMTs carry a clonal rearrangement of the anaplastic lymphoma kinase (ALK) gene, while other receptor tyrosine kinase gene rearrangements have been seen in a small subset of IMT. Herein, we report the first case of IMT which harbors an ALK gene amplification rather than a rearrangement thus resulting in overexpression of the protein, arising from the femur of a 24-year-old man. Our case provides a novel pathogenesis for IMT. An overview of cytogenetic abnormalities of IMT is also integrated into this report.

Authors+Show Affiliations

Department of Pathology, the University of Alabama at Birmingham, Birmingham, AL 35249, United States.Department of Pathology, the University of Alabama at Birmingham, Birmingham, AL 35249, United States.Department of Pathology, the University of Alabama at Birmingham, Birmingham, AL 35249, United States; Department of Genetics, the University of Alabama at Birmingham, Birmingham, AL 35249, United States.Department of Pathology, the University of Alabama at Birmingham, Birmingham, AL 35249, United States. Electronic address: swei@uabmc.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31326196

Citation

Wang, Kai, et al. "Inflammatory Myofibroblastic Tumor of Bone Harboring an ALK Gene Amplification." Pathology, Research and Practice, 2019, p. 152535.
Wang K, Guo R, Siegal GP, et al. Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification. Pathol Res Pract. 2019.
Wang, K., Guo, R., Siegal, G. P., & Wei, S. (2019). Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification. Pathology, Research and Practice, p. 152535. doi:10.1016/j.prp.2019.152535.
Wang K, et al. Inflammatory Myofibroblastic Tumor of Bone Harboring an ALK Gene Amplification. Pathol Res Pract. 2019 Jul 13;152535. PubMed PMID: 31326196.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory myofibroblastic tumor of bone harboring an ALK gene amplification. AU - Wang,Kai, AU - Guo,Rongjun, AU - Siegal,Gene P, AU - Wei,Shi, Y1 - 2019/07/13/ PY - 2019/05/04/received PY - 2019/06/14/revised PY - 2019/07/12/accepted PY - 2019/7/22/entrez PY - 2019/7/22/pubmed PY - 2019/7/22/medline KW - Amplification KW - Anaplastic lymphoma kinase KW - Gene KW - Inflammatory myofibroblastic tumor KW - Rearrangement SP - 152535 EP - 152535 JF - Pathology, research and practice JO - Pathol. Res. Pract. N2 - Inflammatory myofibroblastic tumor (IMT) is a neoplastic proliferation of myofibroblastic/fibroblastic cells with a variable admixture of inflammatory cells. It primarily affects soft tissue and viscera of children and young adults. IMT occurring in bone is extremely rare. Approximately 50% of IMTs carry a clonal rearrangement of the anaplastic lymphoma kinase (ALK) gene, while other receptor tyrosine kinase gene rearrangements have been seen in a small subset of IMT. Herein, we report the first case of IMT which harbors an ALK gene amplification rather than a rearrangement thus resulting in overexpression of the protein, arising from the femur of a 24-year-old man. Our case provides a novel pathogenesis for IMT. An overview of cytogenetic abnormalities of IMT is also integrated into this report. SN - 1618-0631 UR - https://www.unboundmedicine.com/medline/citation/31326196/Inflammatory_myofibroblastic_tumor_of_bone_harboring_an_ALK_gene_amplification L2 - https://linkinghub.elsevier.com/retrieve/pii/S0344-0338(19)30839-8 DB - PRIME DP - Unbound Medicine ER -