Tags

Type your tag names separated by a space and hit enter

Development and validation of a new intraocular pressure estimate for patients with soft corneas.

Abstract

PURPOSE

To introduce and clinically validate a new method of estimating intraocular pressure (IOP) in patients with keratoconus and soft corneas with the aim of significantly reducing dependence on corneal biomechanics.

SETTING

Vincieye Clinic, Milan, Italy, and Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil.

DESIGN

Retrospective case series.

METHOD

This study comprised participants enrolled at two hospitals on two continents. Numerical analysis based on the finite element method was performed to simulate the effect of tonometric air pressure of the Corvis ST dynamic Scheimpflug analyzer on eye globes with wide variations in thickness, geometry, and tissue. The numerical predictions of ocular behavior were used to develop a new algorithm to produce predictions of the biomechanically corrected IOP (bIOP) in eyes with a soft cornea (bIOPs). Predictions of the bIOPs were assessed in the keratoconic clinical datasets (because on average these corneas are softer) and compared with the previously developed bIOP algorithm predictions obtained for normal healthy eyes.

RESULTS

The study comprised 722 eyes (722 participants). The main outcome was the absence of a significant difference in IOP between healthy eyes and keratoconic eyes when the bIOP and bIOPs algorithms were used (P > .05). There was, however, a significant difference with the uncorrected Scheimpflug analyzer IOP in both groups (P < .001). Furthermore, the bIOPs predictions were significantly less affected by corneal thickness and patient age than the Scheimpflug analyzer IOP.

CONCLUSION

The bIOPs algorithm was more reliable at estimating the IOP in eyes with a soft cornea and was validated for use in eyes with keratoconus.

Authors+Show Affiliations

School of Engineering, University of Liverpool, United Kingdom.School of Engineering, University of Liverpool, United Kingdom. Electronic address: eliasy.ashkan@gmail.com.School of Engineering, University of Liverpool, United Kingdom; Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals, Birmingham, United Kingdom.School of Engineering, University of Liverpool, United Kingdom.School of Engineering, University of Liverpool, United Kingdom; Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil; Department of Ophthalmology, Federal University of São Paulo, Brazil.Department of Biomedical Science-Humanitas University, Rozzano, Milan, Italy; Eye Center, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil; Department of Ophthalmology, Federal University of São Paulo, Brazil.Department of Ophthalmology & Visual Science, Department of Biomedical Engineering, Ohio State University, Columbus, Ohio, USA.School of Engineering, University of Liverpool, United Kingdom; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, United Kingdom; School of Biological Science and Biomedical Engineering, Beihang University (Elsheikh), Beijing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31326228

Citation

Chen, Kai-Jung, et al. "Development and Validation of a New Intraocular Pressure Estimate for Patients With Soft Corneas." Journal of Cataract and Refractive Surgery, 2019.
Chen KJ, Eliasy A, Vinciguerra R, et al. Development and validation of a new intraocular pressure estimate for patients with soft corneas. J Cataract Refract Surg. 2019.
Chen, K. J., Eliasy, A., Vinciguerra, R., Abass, A., Lopes, B. T., Vinciguerra, P., ... Elsheikh, A. (2019). Development and validation of a new intraocular pressure estimate for patients with soft corneas. Journal of Cataract and Refractive Surgery, doi:10.1016/j.jcrs.2019.04.004.
Chen KJ, et al. Development and Validation of a New Intraocular Pressure Estimate for Patients With Soft Corneas. J Cataract Refract Surg. 2019 Jul 17; PubMed PMID: 31326228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and validation of a new intraocular pressure estimate for patients with soft corneas. AU - Chen,Kai-Jung, AU - Eliasy,Ashkan, AU - Vinciguerra,Riccardo, AU - Abass,Ahmed, AU - Lopes,Bernardo T, AU - Vinciguerra,Paolo, AU - Ambrósio,Renato,Jr AU - Roberts,Cynthia J, AU - Elsheikh,Ahmed, Y1 - 2019/07/17/ PY - 2018/07/23/received PY - 2019/03/20/revised PY - 2019/04/01/accepted PY - 2019/7/22/entrez PY - 2019/7/22/pubmed PY - 2019/7/22/medline JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg N2 - PURPOSE: To introduce and clinically validate a new method of estimating intraocular pressure (IOP) in patients with keratoconus and soft corneas with the aim of significantly reducing dependence on corneal biomechanics. SETTING: Vincieye Clinic, Milan, Italy, and Rio de Janeiro Corneal Tomography and Biomechanics Study Group, Brazil. DESIGN: Retrospective case series. METHOD: This study comprised participants enrolled at two hospitals on two continents. Numerical analysis based on the finite element method was performed to simulate the effect of tonometric air pressure of the Corvis ST dynamic Scheimpflug analyzer on eye globes with wide variations in thickness, geometry, and tissue. The numerical predictions of ocular behavior were used to develop a new algorithm to produce predictions of the biomechanically corrected IOP (bIOP) in eyes with a soft cornea (bIOPs). Predictions of the bIOPs were assessed in the keratoconic clinical datasets (because on average these corneas are softer) and compared with the previously developed bIOP algorithm predictions obtained for normal healthy eyes. RESULTS: The study comprised 722 eyes (722 participants). The main outcome was the absence of a significant difference in IOP between healthy eyes and keratoconic eyes when the bIOP and bIOPs algorithms were used (P > .05). There was, however, a significant difference with the uncorrected Scheimpflug analyzer IOP in both groups (P < .001). Furthermore, the bIOPs predictions were significantly less affected by corneal thickness and patient age than the Scheimpflug analyzer IOP. CONCLUSION: The bIOPs algorithm was more reliable at estimating the IOP in eyes with a soft cornea and was validated for use in eyes with keratoconus. SN - 1873-4502 UR - https://www.unboundmedicine.com/medline/citation/31326228/Development_and_validation_of_a_new_intraocular_pressure_estimate_for_patients_with_soft_corneas L2 - https://linkinghub.elsevier.com/retrieve/pii/S0886-3350(19)30273-1 DB - PRIME DP - Unbound Medicine ER -