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Developmental lung anomalies in adults: A pictorial review.
Respir Med 2019; 155:86-96RM

Abstract

Developmental lung anomalies represent a heterogeneous group of diverse, yet related abnormalities that involve the lung parenchyma, pulmonary vasculature or a combination of both-which usually present prenatally and in early childhood. However, a substantial number of cases go unnoticed during childhood and present either incidentally or with recurrent respiratory infections progressing into adulthood. Defective development of the tracheobronchial tree and the pulmonary vasculature are proposed to cause these developmental anomalies. Encountering these lung anomalies in adults is a diagnostic challenge given their rarity and they are often mistaken as other serious pathological conditions, resulting in unnecessary diagnostic tests and procedures. The developmental lung anomalies in adults can be broadly divided into three categories: bronchopulmonary anomalies encompassing congenital bronchial atresia, bronchogenic cysts, congenital lobar emphysema and congenital pulmonary airway malformations. Vascular anomalies include pulmonary agenesis-aplasia- hypoplasia complex, unilateral absence of the pulmonary artery, pulmonary artery sling, partial anomalous pulmonary venous return, pulmonary venous varix and pulmonary arteriovenous malformations. Finally combined lung parenchymal-vascular anomalies of the lung involve hypogenetic lung (scimitar) syndrome and bronchopulmonary sequestration. This article discusses the spectrum of these developmental anomalies of the lung, their etiopathogenesis, clinical and radiographic presentations in adults and management in brief.

Authors+Show Affiliations

Divisions of Pulmonary, Critical Care and Sleep Medicine, USA; McGovern Medical School, The University of Texas Health Science Center at Houston, TX, 77030, USA. Electronic address: sujith.v.cherian@uth.tmc.edu.Divisions of Pulmonary, Critical Care and Sleep Medicine, USA; Spectrum Health-Michigan State University College of Human Medicine, Grand Rapids, MI, 49503, USA. Electronic address: anupamkumarmd@gmail.com.McGovern Medical School, The University of Texas Health Science Center at Houston, TX, 77030, USA; Department of Diagnostic and Interventional Imaging, USA. Electronic address: Daniel.OcazionezTrujillo@uth.tmc.edu.McGovern Medical School, The University of Texas Health Science Center at Houston, TX, 77030, USA; Divisions of Pulmonary, Critical Care and Sleep Medicine, USA. Electronic address: rosa.m.estrada.y.martin@uth.tmc.edu.Vice Chair of Education, Director, Cardio-Thoracic Radiology, USA; University of Texas Health Science Center -UT Health, San Antonio, TX, USA. Electronic address: restrepoc@uthscsa.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31326738

Citation

Cherian, Sujith V., et al. "Developmental Lung Anomalies in Adults: a Pictorial Review." Respiratory Medicine, vol. 155, 2019, pp. 86-96.
Cherian SV, Kumar A, Ocazionez D, et al. Developmental lung anomalies in adults: A pictorial review. Respir Med. 2019;155:86-96.
Cherian, S. V., Kumar, A., Ocazionez, D., Estrada-Y-Martin, R. M., & Restrepo, C. S. (2019). Developmental lung anomalies in adults: A pictorial review. Respiratory Medicine, 155, pp. 86-96. doi:10.1016/j.rmed.2019.07.011.
Cherian SV, et al. Developmental Lung Anomalies in Adults: a Pictorial Review. Respir Med. 2019;155:86-96. PubMed PMID: 31326738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Developmental lung anomalies in adults: A pictorial review. AU - Cherian,Sujith V, AU - Kumar,Anupam, AU - Ocazionez,Daniel, AU - Estrada-Y-Martin,Rosa M, AU - Restrepo,Carlos Santiago, Y1 - 2019/07/11/ PY - 2019/02/09/received PY - 2019/06/03/revised PY - 2019/07/05/accepted PY - 2019/7/22/pubmed PY - 2019/7/22/medline PY - 2019/7/22/entrez KW - Developmental anomalies KW - Lung KW - Radiology KW - Vascular SP - 86 EP - 96 JF - Respiratory medicine JO - Respir Med VL - 155 N2 - Developmental lung anomalies represent a heterogeneous group of diverse, yet related abnormalities that involve the lung parenchyma, pulmonary vasculature or a combination of both-which usually present prenatally and in early childhood. However, a substantial number of cases go unnoticed during childhood and present either incidentally or with recurrent respiratory infections progressing into adulthood. Defective development of the tracheobronchial tree and the pulmonary vasculature are proposed to cause these developmental anomalies. Encountering these lung anomalies in adults is a diagnostic challenge given their rarity and they are often mistaken as other serious pathological conditions, resulting in unnecessary diagnostic tests and procedures. The developmental lung anomalies in adults can be broadly divided into three categories: bronchopulmonary anomalies encompassing congenital bronchial atresia, bronchogenic cysts, congenital lobar emphysema and congenital pulmonary airway malformations. Vascular anomalies include pulmonary agenesis-aplasia- hypoplasia complex, unilateral absence of the pulmonary artery, pulmonary artery sling, partial anomalous pulmonary venous return, pulmonary venous varix and pulmonary arteriovenous malformations. Finally combined lung parenchymal-vascular anomalies of the lung involve hypogenetic lung (scimitar) syndrome and bronchopulmonary sequestration. This article discusses the spectrum of these developmental anomalies of the lung, their etiopathogenesis, clinical and radiographic presentations in adults and management in brief. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/31326738/Developmental_lung_anomalies_in_adults:_A_pictorial_review L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(19)30235-5 DB - PRIME DP - Unbound Medicine ER -