Tags

Type your tag names separated by a space and hit enter

Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia.

Abstract

Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate fasciculus (Arc) and superior longitudinal fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure.

Authors+Show Affiliations

School of Life Science and Technology, Xidian University, Xi'an, Shanxi, 710071, People's Republic of China. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.School of Life Science and Technology, Xidian University, Xi'an, Shanxi, 710071, People's Republic of China. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.School of Life Science and Technology, Xidian University, Xi'an, Shanxi, 710071, People's Republic of China. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China.Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China.Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. fmydh@imust.edu.cn.School of Life Science and Technology, Xidian University, Xi'an, Shanxi, 710071, People's Republic of China. kyuan@xidian.edu.cn. Engineering Research Center of Molecular and Neuro Imaging Ministry of Education, Xi'an, People's Republic of China. kyuan@xidian.edu.cn. Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, Information Processing Laboratory, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, People's Republic of China. kyuan@xidian.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31327125

Citation

Cai, Wanye, et al. "Right Arcuate Fasciculus and Superior Longitudinal Fasciculus Abnormalities in Primary Insomnia." Brain Imaging and Behavior, 2019.
Cai W, Zhao M, Liu J, et al. Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia. Brain Imaging Behav. 2019.
Cai, W., Zhao, M., Liu, J., Liu, B., Yu, D., & Yuan, K. (2019). Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia. Brain Imaging and Behavior, doi:10.1007/s11682-019-00160-1.
Cai W, et al. Right Arcuate Fasciculus and Superior Longitudinal Fasciculus Abnormalities in Primary Insomnia. Brain Imaging Behav. 2019 Jul 20; PubMed PMID: 31327125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Right arcuate fasciculus and superior longitudinal fasciculus abnormalities in primary insomnia. AU - Cai,Wanye, AU - Zhao,Meng, AU - Liu,Jingjing, AU - Liu,Bo, AU - Yu,Dahua, AU - Yuan,Kai, Y1 - 2019/07/20/ PY - 2019/7/22/entrez PY - 2019/7/22/pubmed PY - 2019/7/22/medline KW - Insomnia KW - Pittsburgh sleep quality index KW - Tractography KW - White matter JF - Brain imaging and behavior JO - Brain Imaging Behav N2 - Primary insomnia (PI) is a very common phenomenon and associated with functional impairments of attention, memory and mood regulation. However, its neurobiology is poorly understood. To date, the studies about integrity of white matter (WM) tracts in PI patients have been still rare. In the present study, we used Automated Fiber Quantification (AFQ), which reliably and efficiently quantified diffusion measurements at multiple locations along the WM trajectory based on diffusion tensor imaging (DTI), to assess WM diffusion properties differences between 23 PI patients and 32 matched healthy controls in 18 tracts. The relationships between neuroimaging differences and sleep behaviors were explored, including Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index Scale (ISI). Compared with healthy control group, right arcuate fasciculus (Arc) and superior longitudinal fasciculus (SLF) showed significant higher fractional anisotropy (FA), mean diffusivity (MD) and radial diffusivity (RD) along tract length in PI patients (FWE corrected, p < 0.01). Axial diffusivity (AD) for PI patients was higher in right Arc and lower in right SLF. Correlation analyses revealed that FA of right Arc and MD of right SLF were negatively correlated with PSQI score in PI patients, and AD of right Arc and FA of right SLF were positively correlated with PSQI score. Negative correlation was observed between FA of right Arc and AD of right SLF and ISI score in PI patients. Our findings can help us to improve the understanding of the neural mechanisms of primary insomnia at abnormalities in WM microstructure. SN - 1931-7565 UR - https://www.unboundmedicine.com/medline/citation/31327125/Right_arcuate_fasciculus_and_superior_longitudinal_fasciculus_abnormalities_in_primary_insomnia L2 - https://dx.doi.org/10.1007/s11682-019-00160-1 DB - PRIME DP - Unbound Medicine ER -