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An investigation of efficacy, safety, and prognostic factors of drug-eluting beads-transarterial chemoembolization operation with CalliSpheres® Microspheres in treating Chinese hepatocellular carcinoma patients.
J Clin Lab Anal. 2019 Oct; 33(8):e22975.JC

Abstract

BACKGROUND

We aimed to investigate treatment response, survival profiles, safety profiles, and predictive factors of drug-eluting beads-transarterial chemoembolization (DEB-TACE) with CalliSpheres® Microspheres (CSM) in treating Chinese hepatocellular carcinoma (HCC) patients.

METHODS

A total of 66 HCC patients about to receive DEB-TACE with CSM therapy were consecutively enrolled in this prospective cohort study. Treatment response was recorded. Besides, progression-free survival (PFS) and overall survival (OS) were also recorded. All adverse events including pain, nausea, vomiting, fever, and liver function damage were recorded during hospitalization.

RESULTS

37.9% of patients achieved complete response (CR) and 81.8% of patients achieved an objective response rate (ORR). For survival, mean PFS and OS were 13.7 (11.7-15.8) months and 18.8 (95% CI: 16.3-21.2) months, respectively. Multivariate logistic regression analysis revealed that a number of nodules ≥2 was an independent factor for worse CR; moreover, multivariate Cox's regression analysis disclosed that largest sample size ≥5 cm was an independent factor for shorter PFS, and Child-Pugh B and BCLC stage B/C were independent predictive factors for unfavorable OS. As to AEs, numbers of patients suffered liver function damage, pain, nausea, vomiting, and fever were 29 (43.9%), 27 (40.9%), 22 (33.3%), 13 (19.7%), and 37 (56.1%), respectively.

CONCLUSION

Drug-eluting beads-transarterial chemoembolization with CSM is an effective and tolerated treatment for Chinese HCC patients, and number of nodules ≥2, largest nodule size ≥5 cm, Child-Pugh stage B, and BCLC stage B/C correlates with unfavorable prognosis.

Authors+Show Affiliations

Department of Radiology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.Department of Radiology, Shengzhou People's Hospital, Shengzhou, China.Department of Radiology, Shengzhou People's Hospital, Shengzhou, China.Department of Radiology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31328832

Citation

Zhang, Xin, et al. "An Investigation of Efficacy, Safety, and Prognostic Factors of Drug-eluting Beads-transarterial Chemoembolization Operation With CalliSpheres® Microspheres in Treating Chinese Hepatocellular Carcinoma Patients." Journal of Clinical Laboratory Analysis, vol. 33, no. 8, 2019, pp. e22975.
Zhang X, Lin X, Qiu H, et al. An investigation of efficacy, safety, and prognostic factors of drug-eluting beads-transarterial chemoembolization operation with CalliSpheres® Microspheres in treating Chinese hepatocellular carcinoma patients. J Clin Lab Anal. 2019;33(8):e22975.
Zhang, X., Lin, X., Qiu, H., & Peng, Z. (2019). An investigation of efficacy, safety, and prognostic factors of drug-eluting beads-transarterial chemoembolization operation with CalliSpheres® Microspheres in treating Chinese hepatocellular carcinoma patients. Journal of Clinical Laboratory Analysis, 33(8), e22975. https://doi.org/10.1002/jcla.22975
Zhang X, et al. An Investigation of Efficacy, Safety, and Prognostic Factors of Drug-eluting Beads-transarterial Chemoembolization Operation With CalliSpheres® Microspheres in Treating Chinese Hepatocellular Carcinoma Patients. J Clin Lab Anal. 2019;33(8):e22975. PubMed PMID: 31328832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An investigation of efficacy, safety, and prognostic factors of drug-eluting beads-transarterial chemoembolization operation with CalliSpheres® Microspheres in treating Chinese hepatocellular carcinoma patients. AU - Zhang,Xin, AU - Lin,Xiao, AU - Qiu,Huafeng, AU - Peng,Zhiyi, Y1 - 2019/07/22/ PY - 2019/04/18/received PY - 2019/06/19/revised PY - 2019/06/21/accepted PY - 2019/7/23/pubmed PY - 2020/3/13/medline PY - 2019/7/23/entrez KW - drug-eluting beads-transarterial chemoembolization KW - hepatocellular carcinoma KW - predictive factor KW - safety KW - treatment response SP - e22975 EP - e22975 JF - Journal of clinical laboratory analysis JO - J. Clin. Lab. Anal. VL - 33 IS - 8 N2 - BACKGROUND: We aimed to investigate treatment response, survival profiles, safety profiles, and predictive factors of drug-eluting beads-transarterial chemoembolization (DEB-TACE) with CalliSpheres® Microspheres (CSM) in treating Chinese hepatocellular carcinoma (HCC) patients. METHODS: A total of 66 HCC patients about to receive DEB-TACE with CSM therapy were consecutively enrolled in this prospective cohort study. Treatment response was recorded. Besides, progression-free survival (PFS) and overall survival (OS) were also recorded. All adverse events including pain, nausea, vomiting, fever, and liver function damage were recorded during hospitalization. RESULTS: 37.9% of patients achieved complete response (CR) and 81.8% of patients achieved an objective response rate (ORR). For survival, mean PFS and OS were 13.7 (11.7-15.8) months and 18.8 (95% CI: 16.3-21.2) months, respectively. Multivariate logistic regression analysis revealed that a number of nodules ≥2 was an independent factor for worse CR; moreover, multivariate Cox's regression analysis disclosed that largest sample size ≥5 cm was an independent factor for shorter PFS, and Child-Pugh B and BCLC stage B/C were independent predictive factors for unfavorable OS. As to AEs, numbers of patients suffered liver function damage, pain, nausea, vomiting, and fever were 29 (43.9%), 27 (40.9%), 22 (33.3%), 13 (19.7%), and 37 (56.1%), respectively. CONCLUSION: Drug-eluting beads-transarterial chemoembolization with CSM is an effective and tolerated treatment for Chinese HCC patients, and number of nodules ≥2, largest nodule size ≥5 cm, Child-Pugh stage B, and BCLC stage B/C correlates with unfavorable prognosis. SN - 1098-2825 UR - https://www.unboundmedicine.com/medline/citation/31328832/An_investigation_of_efficacy_safety_and_prognostic_factors_of_drug_eluting_beads_transarterial_chemoembolization_operation_with_CalliSpheres®_Microspheres_in_treating_Chinese_hepatocellular_carcinoma_patients_ L2 - https://doi.org/10.1002/jcla.22975 DB - PRIME DP - Unbound Medicine ER -