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Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance.
Obesity (Silver Spring). 2019 09; 27(9):1443-1450.O

Abstract

OBJECTIVE

This study compared the effects of alternate-day fasting (ADF) with those of daily calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight or obesity and insulin resistance.

METHODS

This secondary analysis examined the data of insulin-resistant individuals (n = 43) who participated in a 12-month study that compared ADF (25% energy needs on "fast days"; 125% energy needs on alternating "feast days") with CR (75% energy needs every day) and a control group regimen.

RESULTS

In insulin-resistant participants, weight loss was not different between ADF (-8% ± 2%) and CR (-6% ± 1%) by month 12, relative to controls (P < 0.0001). Fat mass and BMI decreased (P < 0.05) similarly from ADF and CR. ADF produced greater decreases (P < 0.05) in fasting insulin (-52% ± 9%) and insulin resistance (-53% ± 9%) compared with CR (-14% ± 9%; -17% ± 11%) and the control regimen by month 12. Lean mass, visceral fat mass, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, blood pressure, C-reactive protein, tumor necrosis factor α, and interleukin 6 values remained unchanged.

CONCLUSIONS

These findings suggest that ADF may produce greater reductions in fasting insulin and insulin resistance compared with CR in insulin-resistant participants despite similar decreases in body weight.

Authors+Show Affiliations

Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA. Charles Perkins Center, The University of Sydney, Sydney, New South Wales, Australia.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31328895

Citation

Gabel, Kelsey, et al. "Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction On Insulin Resistance." Obesity (Silver Spring, Md.), vol. 27, no. 9, 2019, pp. 1443-1450.
Gabel K, Kroeger CM, Trepanowski JF, et al. Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance. Obesity (Silver Spring). 2019;27(9):1443-1450.
Gabel, K., Kroeger, C. M., Trepanowski, J. F., Hoddy, K. K., Cienfuegos, S., Kalam, F., & Varady, K. A. (2019). Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance. Obesity (Silver Spring, Md.), 27(9), 1443-1450. https://doi.org/10.1002/oby.22564
Gabel K, et al. Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction On Insulin Resistance. Obesity (Silver Spring). 2019;27(9):1443-1450. PubMed PMID: 31328895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance. AU - Gabel,Kelsey, AU - Kroeger,Cynthia M, AU - Trepanowski,John F, AU - Hoddy,Kristin K, AU - Cienfuegos,Sofia, AU - Kalam,Faiza, AU - Varady,Krista A, Y1 - 2019/07/22/ PY - 2019/02/12/received PY - 2019/05/22/accepted PY - 2019/7/23/pubmed PY - 2020/4/24/medline PY - 2019/7/23/entrez SP - 1443 EP - 1450 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 27 IS - 9 N2 - OBJECTIVE: This study compared the effects of alternate-day fasting (ADF) with those of daily calorie restriction (CR) on body weight and glucoregulatory factors in adults with overweight or obesity and insulin resistance. METHODS: This secondary analysis examined the data of insulin-resistant individuals (n = 43) who participated in a 12-month study that compared ADF (25% energy needs on "fast days"; 125% energy needs on alternating "feast days") with CR (75% energy needs every day) and a control group regimen. RESULTS: In insulin-resistant participants, weight loss was not different between ADF (-8% ± 2%) and CR (-6% ± 1%) by month 12, relative to controls (P < 0.0001). Fat mass and BMI decreased (P < 0.05) similarly from ADF and CR. ADF produced greater decreases (P < 0.05) in fasting insulin (-52% ± 9%) and insulin resistance (-53% ± 9%) compared with CR (-14% ± 9%; -17% ± 11%) and the control regimen by month 12. Lean mass, visceral fat mass, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, blood pressure, C-reactive protein, tumor necrosis factor α, and interleukin 6 values remained unchanged. CONCLUSIONS: These findings suggest that ADF may produce greater reductions in fasting insulin and insulin resistance compared with CR in insulin-resistant participants despite similar decreases in body weight. SN - 1930-739X UR - https://www.unboundmedicine.com/medline/citation/31328895/Differential_Effects_of_Alternate_Day_Fasting_Versus_Daily_Calorie_Restriction_on_Insulin_Resistance_ L2 - https://doi.org/10.1002/oby.22564 DB - PRIME DP - Unbound Medicine ER -