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Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO.
Biogerontology. 2019 10; 20(5):665-676.B

Abstract

Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have antiaging properties. In Eastern countries, LYG is used to delay functional declines related to aging and has an obvious antiaging effect in clinical practice. However, little data from evidence-based medicine is available regarding whether LYG is beneficial overall, particularly with respect to lifespan, and how LYG functions. To address these issues, Caenorhabditis elegans, a useful organism for such studies, was employed to explore the antiaging effect and mechanism of LYG in this study. The results showed that LYG could obviously extend lifespan and slow aging-related declines in N2 wild-type C. elegans. To further characterize these antiaging effects and stress resistance, reproductive tests and other aging-related tests were performed. We found that LYG enhanced resistance against oxidative and thermal stress, reproduction, pharynx pumping, motility and growth in N2 wild-type C. elegans. In addition, we analyzed the mechanism for these effects by measuring the activity of superoxide dismutase (SOD) and the expression levels of aging-related genes. We found that LYG enhanced the activities of antioxidant enzymes and upregulated the genes daf-16, sod-3 and sir-2.1, which mediated stress resistance and longevity. In conclusion, LYG had robust and reproducible life-prolonging and antiaging benefits in C. elegans via DAF-16/FOXO regulation.

Authors+Show Affiliations

The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.Guangdong Provincial Hospital of Chinese Medicine, 111 Da De Rd, Yuexiu District, Guangzhou, 510120, Guangdong Province, China.Department of Neurology, National Key Clinical, Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.Department of Neurology, National Key Clinical, Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.Department of Neurology, National Key Clinical, Department and Key Discipline of Neurology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.Guangdong Provincial Hospital of Chinese Medicine, 111 Da De Rd, Yuexiu District, Guangzhou, 510120, Guangdong Province, China. yangyo@vip.tom.com.Guangdong Provincial Hospital of Chinese Medicine, 111 Da De Rd, Yuexiu District, Guangzhou, 510120, Guangdong Province, China. xufuping163@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31332584

Citation

Zeng, Liling, et al. "Liangyi Gao Extends Lifespan and Exerts an Antiaging Effect in Caenorhabditis Elegans By Modulating DAF-16/FOXO." Biogerontology, vol. 20, no. 5, 2019, pp. 665-676.
Zeng L, Sun C, Pei Z, et al. Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. Biogerontology. 2019;20(5):665-676.
Zeng, L., Sun, C., Pei, Z., Yun, T., Fan, S., Long, S., Wu, T., Chen, Z., Yang, Z., & Xu, F. (2019). Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. Biogerontology, 20(5), 665-676. https://doi.org/10.1007/s10522-019-09820-7
Zeng L, et al. Liangyi Gao Extends Lifespan and Exerts an Antiaging Effect in Caenorhabditis Elegans By Modulating DAF-16/FOXO. Biogerontology. 2019;20(5):665-676. PubMed PMID: 31332584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO. AU - Zeng,Liling, AU - Sun,Chen, AU - Pei,Zhong, AU - Yun,Tianchan, AU - Fan,Shaoyi, AU - Long,Simei, AU - Wu,Tengteng, AU - Chen,Ziwen, AU - Yang,Zhimin, AU - Xu,Fuping, Y1 - 2019/07/22/ PY - 2019/04/02/received PY - 2019/07/10/accepted PY - 2019/7/25/pubmed PY - 2020/3/21/medline PY - 2019/7/24/entrez KW - Antiaging KW - Caenorhabditis elegans KW - DAF-16/FOXO regulation KW - Liangyi Gao KW - Traditional Chinese Medicine SP - 665 EP - 676 JF - Biogerontology JO - Biogerontology VL - 20 IS - 5 N2 - Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have antiaging properties. In Eastern countries, LYG is used to delay functional declines related to aging and has an obvious antiaging effect in clinical practice. However, little data from evidence-based medicine is available regarding whether LYG is beneficial overall, particularly with respect to lifespan, and how LYG functions. To address these issues, Caenorhabditis elegans, a useful organism for such studies, was employed to explore the antiaging effect and mechanism of LYG in this study. The results showed that LYG could obviously extend lifespan and slow aging-related declines in N2 wild-type C. elegans. To further characterize these antiaging effects and stress resistance, reproductive tests and other aging-related tests were performed. We found that LYG enhanced resistance against oxidative and thermal stress, reproduction, pharynx pumping, motility and growth in N2 wild-type C. elegans. In addition, we analyzed the mechanism for these effects by measuring the activity of superoxide dismutase (SOD) and the expression levels of aging-related genes. We found that LYG enhanced the activities of antioxidant enzymes and upregulated the genes daf-16, sod-3 and sir-2.1, which mediated stress resistance and longevity. In conclusion, LYG had robust and reproducible life-prolonging and antiaging benefits in C. elegans via DAF-16/FOXO regulation. SN - 1573-6768 UR - https://www.unboundmedicine.com/medline/citation/31332584/Liangyi_Gao_extends_lifespan_and_exerts_an_antiaging_effect_in_Caenorhabditis_elegans_by_modulating_DAF_16/FOXO_ L2 - https://doi.org/10.1007/s10522-019-09820-7 DB - PRIME DP - Unbound Medicine ER -