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Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films.
Curr Pharm Biotechnol. 2019; 20(12):1064-1071.CP

Abstract

BACKGROUND

Biodegradable films are appropriate alternatives to synthetic polymers due to their potential to enhance food safety and their function as a carrier for wide a range of food additives especially natural antioxidants.

OBJECTIVE

The aim of this study was to compare the potential antioxidant activities of sodium alginate films containing resveratrol (RES) alone and in combination with Zataria multiflora essential oil (ZEO) using an in vitro model.

METHODS

At first, the major chemical compositions of ZEO were evaluated by GC/MS. Then, the amount of phenolic compounds of sodium alginate films were evaluated by total phenolic contents assay and antioxidant activities of films were evaluated by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Finally, the concentrations of ZEO and RES which showed better antioxidant activities in sodium alginate films were incorporated to films in combination forms to evaluate their synergistic effects.

RESULTS

According to gas chromatography-mass spectrometry (GC/MS) analysis, 35 compounds of ZEO were identified and Thymol (37.94%), p-Cymene (9.50%) and 3-Carene (4.98%) were the most important compounds of essential oil, respectively. The results of the radical scavenging evaluations, showed better antioxidant activities of the films containing RES than the films containing ZEO and Butylated hydroxytoluene (BHT). Also, the combined uses of ZEO and RES into alginate films had the synergistic effects (P<0.05).

CONCLUSION

Therefore, it can be concluded that alginate films incorporated with the combination of ZEO and RES is the appropriate option to postpone the oxidative reactions and can be used as natural antioxidant in the food packaging industry.

Authors+Show Affiliations

Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran. Student Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran.Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.Department of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31333125

Citation

Hashemi, Mahsa, et al. "Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria Multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films." Current Pharmaceutical Biotechnology, vol. 20, no. 12, 2019, pp. 1064-1071.
Hashemi M, Hashemi M, Amiri E, et al. Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films. Curr Pharm Biotechnol. 2019;20(12):1064-1071.
Hashemi, M., Hashemi, M., Amiri, E., Hassanzadazar, H., Daneshamooz, S., & Aminzare, M. (2019). Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films. Current Pharmaceutical Biotechnology, 20(12), 1064-1071. https://doi.org/10.2174/1389201020666190719143910
Hashemi M, et al. Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria Multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films. Curr Pharm Biotechnol. 2019;20(12):1064-1071. PubMed PMID: 31333125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the Synergistic Antioxidant Effect of Resveratrol and Zataria multiflora Boiss Essential Oil in Sodium Alginate Bioactive Films. AU - Hashemi,Mahsa, AU - Hashemi,Mohammad, AU - Amiri,Elham, AU - Hassanzadazar,Hassan, AU - Daneshamooz,Shahrzad, AU - Aminzare,Majid, PY - 2019/03/05/received PY - 2019/05/13/revised PY - 2019/05/15/accepted PY - 2019/7/25/pubmed PY - 2020/1/22/medline PY - 2019/7/24/entrez KW - Resveratrol KW - Zataria multiflora KW - alginate film KW - essential oil KW - natural antioxidant KW - radical scavenging activity. SP - 1064 EP - 1071 JF - Current pharmaceutical biotechnology JO - Curr Pharm Biotechnol VL - 20 IS - 12 N2 - BACKGROUND: Biodegradable films are appropriate alternatives to synthetic polymers due to their potential to enhance food safety and their function as a carrier for wide a range of food additives especially natural antioxidants. OBJECTIVE: The aim of this study was to compare the potential antioxidant activities of sodium alginate films containing resveratrol (RES) alone and in combination with Zataria multiflora essential oil (ZEO) using an in vitro model. METHODS: At first, the major chemical compositions of ZEO were evaluated by GC/MS. Then, the amount of phenolic compounds of sodium alginate films were evaluated by total phenolic contents assay and antioxidant activities of films were evaluated by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Finally, the concentrations of ZEO and RES which showed better antioxidant activities in sodium alginate films were incorporated to films in combination forms to evaluate their synergistic effects. RESULTS: According to gas chromatography-mass spectrometry (GC/MS) analysis, 35 compounds of ZEO were identified and Thymol (37.94%), p-Cymene (9.50%) and 3-Carene (4.98%) were the most important compounds of essential oil, respectively. The results of the radical scavenging evaluations, showed better antioxidant activities of the films containing RES than the films containing ZEO and Butylated hydroxytoluene (BHT). Also, the combined uses of ZEO and RES into alginate films had the synergistic effects (P<0.05). CONCLUSION: Therefore, it can be concluded that alginate films incorporated with the combination of ZEO and RES is the appropriate option to postpone the oxidative reactions and can be used as natural antioxidant in the food packaging industry. SN - 1873-4316 UR - https://www.unboundmedicine.com/medline/citation/31333125/Evaluation_of_the_Synergistic_Antioxidant_Effect_of_Resveratrol_and_Zataria_multiflora_Boiss_Essential_Oil_in_Sodium_Alginate_Bioactive_Films_ DB - PRIME DP - Unbound Medicine ER -