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A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk.
J Nutr. 2019 11 01; 149(11):1920-1929.JN

Abstract

BACKGROUND

Adherence to a Mediterranean diet (MedDiet) is thought to reduce liver steatosis.

OBJECTIVES

To explore the associations with liver steatosis of 3 different diets: a MedDiet + extra-virgin olive oil (EVOO), MedDiet + nuts, or a control diet.

METHODS

This was a subgroup analysis nested within a multicenter, randomized, parallel-group clinical trial, PREvención con DIeta MEDiterránea (PREDIMED trial: ISRCTN35739639), aimed at assessing the effect of a MedDiet on the primary prevention of cardiovascular disease. One hundred men and women (mean age: 64 ± 6 y), at high cardiovascular risk (62% with type 2 diabetes) from the Bellvitge-PREDIMED center were randomly assigned to a MedDiet supplemented with EVOO, a MedDiet supplemented with mixed nuts, or a control diet (advice to reduce all dietary fat). No recommendations to lose weight or increase physical activity were given. Main measurements were the percentage of liver fat and the diagnosis of steatosis, which were determined by NMR imaging. The association of diet with liver fat content was analyzed by bivariate analysis after a median follow-up of 3 y.

RESULTS

Baseline adiposity and cardiometabolic risk factors were similar among the 3 treatment arms. At 3 y after the intervention hepatic steatosis was present in 3 (8.8%), 12 (33.3%), and 10 (33.3%) of the participants in the MedDiet + EVOO, MedDiet + nuts, and control diet groups, respectively (P = 0.027). Respective mean values of liver fat content were 1.2%, 2.7%, and 4.1% (P = 0.07). A tendency toward significance was observed for the MedDiet + EVOO group compared with the control group. Median values of urinary 12(S)-hydroxyeicosatetraenoic acid/creatinine concentrations were significantly (P = 0.001) lower in the MedDiet + EVOO (2.3 ng/mg) than in the MedDiet + nuts (5.0 ng/mg) and control (3.9 ng/mg) groups. No differences in adiposity or glycemic control changes were seen between groups.

CONCLUSIONS

An energy-unrestricted MedDiet supplemented with EVOO, a food with potent antioxidant and anti-inflammatory properties, is associated with a reduced prevalence of hepatic steatosis in older individuals at high cardiovascular risk.

Authors+Show Affiliations

Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain. Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain. Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain. Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.Departament de Biologia Cel.lular, Fisiologia i Immunologia, Facultat de Biologia, INSA-UB, Universidad de Barcelona, Barcelona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Departamento de Nutrición, Ciencias de la Alimentación y Gastronomía, Facultad de Farmacia y Ciencias de la Alimentación, Campus de la Alimentación Torribera, INSA-UB, Universidad de Barcelona, Barcelona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Internal Medicine, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Preventive Medicine, University of Valencia, Valencia, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Human Nutrition Department, Hospital Universitari Sant Joan, Institut d'Investigació Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Cardiovascular and Nutrition Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Department of Nutrition and Physiology, University of Navarra, Pamplona, Spain. IMDEA Food, Madrid, Spain.Ciber Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Lipid Clinic, Endocrinology, and Nutrition Service, Hospital Clínic, IDIBAPS, Barcelona, Spain.No affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31334554

Citation

Pintó, Xavier, et al. "A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated With a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk." The Journal of Nutrition, vol. 149, no. 11, 2019, pp. 1920-1929.
Pintó X, Fanlo-Maresma M, Corbella E, et al. A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk. J Nutr. 2019;149(11):1920-1929.
Pintó, X., Fanlo-Maresma, M., Corbella, E., Corbella, X., Mitjavila, M. T., Moreno, J. J., Casas, R., Estruch, R., Corella, D., Bulló, M., Ruiz-Canela, M., Castañer, O., Martinez, J. A., & Ros, E. (2019). A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk. The Journal of Nutrition, 149(11), 1920-1929. https://doi.org/10.1093/jn/nxz147
Pintó X, et al. A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated With a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk. J Nutr. 2019 11 1;149(11):1920-1929. PubMed PMID: 31334554.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk. AU - Pintó,Xavier, AU - Fanlo-Maresma,Marta, AU - Corbella,Emili, AU - Corbella,Xavier, AU - Mitjavila,M Teresa, AU - Moreno,Juan J, AU - Casas,Rosa, AU - Estruch,Ramon, AU - Corella,Dolores, AU - Bulló,Mònica, AU - Ruiz-Canela,Miguel, AU - Castañer,Olga, AU - Martinez,J Alfredo, AU - Ros,Emilio, AU - ,, PY - 2018/11/02/received PY - 2018/11/30/revised PY - 2019/06/04/accepted PY - 2019/7/25/pubmed PY - 2020/6/27/medline PY - 2019/7/24/entrez KW - Mediterranean diet KW - PREDIMED KW - dietary fat KW - hepatic steatosis KW - nuts KW - olive oil SP - 1920 EP - 1929 JF - The Journal of nutrition JO - J. Nutr. VL - 149 IS - 11 N2 - BACKGROUND: Adherence to a Mediterranean diet (MedDiet) is thought to reduce liver steatosis. OBJECTIVES: To explore the associations with liver steatosis of 3 different diets: a MedDiet + extra-virgin olive oil (EVOO), MedDiet + nuts, or a control diet. METHODS: This was a subgroup analysis nested within a multicenter, randomized, parallel-group clinical trial, PREvención con DIeta MEDiterránea (PREDIMED trial: ISRCTN35739639), aimed at assessing the effect of a MedDiet on the primary prevention of cardiovascular disease. One hundred men and women (mean age: 64 ± 6 y), at high cardiovascular risk (62% with type 2 diabetes) from the Bellvitge-PREDIMED center were randomly assigned to a MedDiet supplemented with EVOO, a MedDiet supplemented with mixed nuts, or a control diet (advice to reduce all dietary fat). No recommendations to lose weight or increase physical activity were given. Main measurements were the percentage of liver fat and the diagnosis of steatosis, which were determined by NMR imaging. The association of diet with liver fat content was analyzed by bivariate analysis after a median follow-up of 3 y. RESULTS: Baseline adiposity and cardiometabolic risk factors were similar among the 3 treatment arms. At 3 y after the intervention hepatic steatosis was present in 3 (8.8%), 12 (33.3%), and 10 (33.3%) of the participants in the MedDiet + EVOO, MedDiet + nuts, and control diet groups, respectively (P = 0.027). Respective mean values of liver fat content were 1.2%, 2.7%, and 4.1% (P = 0.07). A tendency toward significance was observed for the MedDiet + EVOO group compared with the control group. Median values of urinary 12(S)-hydroxyeicosatetraenoic acid/creatinine concentrations were significantly (P = 0.001) lower in the MedDiet + EVOO (2.3 ng/mg) than in the MedDiet + nuts (5.0 ng/mg) and control (3.9 ng/mg) groups. No differences in adiposity or glycemic control changes were seen between groups. CONCLUSIONS: An energy-unrestricted MedDiet supplemented with EVOO, a food with potent antioxidant and anti-inflammatory properties, is associated with a reduced prevalence of hepatic steatosis in older individuals at high cardiovascular risk. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/31334554/A_Mediterranean_Diet_Rich_in_Extra_Virgin_Olive_Oil_Is_Associated_with_a_Reduced_Prevalence_of_Nonalcoholic_Fatty_Liver_Disease_in_Older_Individuals_at_High_Cardiovascular_Risk_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxz147 DB - PRIME DP - Unbound Medicine ER -