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Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid
J Drugs Dermatol 2019; 18(7):682-689JD

Abstract

Background:

It is important to study full-face aesthetic combination treatments to establish well-founded individual treatment plans.

Objective:

To evaluate clinical outcome and perception of treatment with either abobotulinumtoxinA (ABO) or hyaluronic acid (HA) filler followed by repeated combined treatment with ABO, HA filler, and Restylane® Skinboosters (RSB). Methods & Materials: This study was conducted at four sites in Sweden, France, and Brazil and included subjects aged 35-50 years with mild/moderate nasolabial folds and moderate/severe upper facial lines. Monotherapy was ≤125 s.U ABO in at least two upper facial indications with optional touch-up or ≤1 mL HA filler in nasolabial folds/cheeks. At months 6 and 12, both cohorts received ≤125 s.U. ABO in upper facial lines with optional touch-up, ≤2 mL HA filler in nasolabial folds/cheeks (and other facial areas as applicable), and ≤1 mL RSB. Assessments included global facial aesthetic appearance and improvement, first impression, perceived age, wrinkle severity, satisfaction questionnaires, and adverse events.

Results:

Repeated full-face treatment with ABO, HA filler, and RSB was associated with better aesthetic outcome and higher levels of satisfaction than treatment with ABO or HA filler alone. However, even modest volumes of HA filler achieved good aesthetic outcomes and high satisfaction. Treatment of several indications was well tolerated.

Conclusion:

Aesthetic improvement and subject satisfaction was high and increased with each treatment. All treatments were well tolerated. These data may be used as support when establishing individual treatment plans. J Drugs Dermatol. 2019;18(7):682-689.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

31334927

Citation

Hedén, Per, et al. "Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid." Journal of Drugs in Dermatology : JDD, vol. 18, no. 7, 2019, pp. 682-689.
Hedén P, Hexsel D, Cartier H, et al. Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid. J Drugs Dermatol. 2019;18(7):682-689.
Hedén, P., Hexsel, D., Cartier, H., Bergentz, P., Delmar, H., Camozzato, F., ... Kestemont, P. (2019). Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid. Journal of Drugs in Dermatology : JDD, 18(7), pp. 682-689.
Hedén P, et al. Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid. J Drugs Dermatol. 2019 Jul 1;18(7):682-689. PubMed PMID: 31334927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effective and Safe Repeated Full-Face Treatments With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin Boosting Hyaluronic Acid AU - Hedén,Per, AU - Hexsel,Doris, AU - Cartier,Hugues, AU - Bergentz,Per, AU - Delmar,Henry, AU - Camozzato,Fernanda, AU - Siega,Carolina, AU - Skoglund,Cecilia, AU - Edwartz,Carolina, AU - Norberg,Maria, AU - Kestemont,Philippe, PY - 2019/7/24/entrez SP - 682 EP - 689 JF - Journal of drugs in dermatology : JDD JO - J Drugs Dermatol VL - 18 IS - 7 N2 - Background: It is important to study full-face aesthetic combination treatments to establish well-founded individual treatment plans. Objective: To evaluate clinical outcome and perception of treatment with either abobotulinumtoxinA (ABO) or hyaluronic acid (HA) filler followed by repeated combined treatment with ABO, HA filler, and Restylane® Skinboosters (RSB). Methods & Materials: This study was conducted at four sites in Sweden, France, and Brazil and included subjects aged 35-50 years with mild/moderate nasolabial folds and moderate/severe upper facial lines. Monotherapy was ≤125 s.U ABO in at least two upper facial indications with optional touch-up or ≤1 mL HA filler in nasolabial folds/cheeks. At months 6 and 12, both cohorts received ≤125 s.U. ABO in upper facial lines with optional touch-up, ≤2 mL HA filler in nasolabial folds/cheeks (and other facial areas as applicable), and ≤1 mL RSB. Assessments included global facial aesthetic appearance and improvement, first impression, perceived age, wrinkle severity, satisfaction questionnaires, and adverse events. Results: Repeated full-face treatment with ABO, HA filler, and RSB was associated with better aesthetic outcome and higher levels of satisfaction than treatment with ABO or HA filler alone. However, even modest volumes of HA filler achieved good aesthetic outcomes and high satisfaction. Treatment of several indications was well tolerated. Conclusion: Aesthetic improvement and subject satisfaction was high and increased with each treatment. All treatments were well tolerated. These data may be used as support when establishing individual treatment plans. J Drugs Dermatol. 2019;18(7):682-689. SN - 1545-9616 UR - https://www.unboundmedicine.com/medline/citation/31334927/Effective_and_Safe_Repeated_Full-Face_Treatments_With_AbobotulinumtoxinA,_Hyaluronic_Acid_Filler,_and_Skin_Boosting_Hyaluronic_Acid L2 - http://jddonline.com/articles/dermatology/S1545961619P0682X DB - PRIME DP - Unbound Medicine ER -