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Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa.
Invest Ophthalmol Vis Sci 2019; 60(8):3135-3141IO

Abstract

Purpose

A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes.

Methods

This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed.

Results

The mean MMCI of RP patients (-13.73 ± 9.63 × 10-5 μm-1) was significantly lower than that of the controls (-6.63 ± 5.63 × 10-5 μm-1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r = 0.20; P = 0.016) and the axial length (r = -0.24; P = 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes.

Conclusions

There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.

Authors+Show Affiliations

Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Department of Ophthalmology, Lund University, Lund, Sweden.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.Nidek Co., Ltd., Gamagori, Japan.Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan.Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31335951

Citation

Komori, Shiori, et al. "Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa." Investigative Ophthalmology & Visual Science, vol. 60, no. 8, 2019, pp. 3135-3141.
Komori S, Ueno S, Ito Y, et al. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2019;60(8):3135-3141.
Komori, S., Ueno, S., Ito, Y., Sayo, A., Meinert, M., Kominami, T., ... Terasaki, H. (2019). Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science, 60(8), pp. 3135-3141. doi:10.1167/iovs.19-27334.
Komori S, et al. Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3135-3141. PubMed PMID: 31335951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa. AU - Komori,Shiori, AU - Ueno,Shinji, AU - Ito,Yasuki, AU - Sayo,Akira, AU - Meinert,Monika, AU - Kominami,Taro, AU - Inooka,Daiki, AU - Kitagawa,Masahiro, AU - Nishida,Kazuki, AU - Takahashi,Kunihiko, AU - Matsui,Shigeyuki, AU - Terasaki,Hiroko, PY - 2019/7/24/entrez SP - 3135 EP - 3141 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 60 IS - 8 N2 - Purpose: A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. Methods: This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. Results: The mean MMCI of RP patients (-13.73 ± 9.63 × 10-5 μm-1) was significantly lower than that of the controls (-6.63 ± 5.63 × 10-5 μm-1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r = 0.20; P = 0.016) and the axial length (r = -0.24; P = 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. Conclusions: There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/31335951/Steeper_Macular_Curvature_in_Eyes_With_Non-Highly_Myopic_Retinitis_Pigmentosa L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.19-27334 DB - PRIME DP - Unbound Medicine ER -