Tags

Type your tag names separated by a space and hit enter

Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway.
Biofactors. 2019 Jul; 45(4):598-606.B

Abstract

Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models of hepatic damage. Metformin (Met) is a potent antidiabetic and redox modulatory agent that has shown anticancer and protective effects on various organs. Therefore, addition of therapy with natural antioxidative agents or herbal extracts shows defensive impacts against different injuries inside the body. Luteolin (Lut) can be found in several customary Chinese remedies. It has been reported for various pharmacological actions such as antitumor, antioxidative, and anti-inflammatory impacts. Here, the liver injury rat model was established using CCl4 (1.00 mL/kg body weight) in vivo. The protective roles of Met and Lut separately or in combination were observed in hepatotoxicity induced by CCl4 . The result was shown that both Met and Lut, while individually used, were normally active in diminishing CCl4 -caused hepatotoxicity. The combination of two drugs performed synergistically to improve liver damage caused by CCl4 , as shown by the considerably improved liver dysfunction. Met and Lut showed highly antioxidative effects on CCl4 -treated rats moderately by increasing the activities and expression of the antioxidant enzymes. Along with this, a combination of Met and Lut significantly suppressed inflammatory responses, which is evidenced by the reduced level of inflammatory cytokines together with interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6). Additionally, CCl4 -agitated apoptosis was intensely reduced by Met and Lut through reducing cleaved caspase-3 and Bax (pro-apoptotic factor) while increasing Bcl-2 (antiapoptotic factor) signaling pathways. Cotreatments of Met and Lut upregulated nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1) expression in the CCl4 -intoxicated rat's liver. The above result recommended that combination of Met and Lut may have a substantial potential and synergizing impact against CCl4 -induced hepatotoxicity.

Authors+Show Affiliations

Department of Digestive Medicine, Hefei Second People's Hospital, Hefei, China.Department of Digestive Medicine, Hefei Second People's Hospital, Hefei, China.Department of Digestive Medicine, Hefei Second People's Hospital, Hefei, China.Department of Internal Medicine, CAS Cancer Hospital, Hefei, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31336028

Citation

Yan, Yang, et al. "Combination of Metformin and Luteolin Synergistically Protects Carbon Tetrachloride-induced Hepatotoxicity: Mechanism Involves Antioxidant, Anti-inflammatory, Antiapoptotic, and Nrf2/HO-1 Signaling Pathway." BioFactors (Oxford, England), vol. 45, no. 4, 2019, pp. 598-606.
Yan Y, Jun C, Lu Y, et al. Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway. Biofactors. 2019;45(4):598-606.
Yan, Y., Jun, C., Lu, Y., & Jiangmei, S. (2019). Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway. BioFactors (Oxford, England), 45(4), 598-606. https://doi.org/10.1002/biof.1521
Yan Y, et al. Combination of Metformin and Luteolin Synergistically Protects Carbon Tetrachloride-induced Hepatotoxicity: Mechanism Involves Antioxidant, Anti-inflammatory, Antiapoptotic, and Nrf2/HO-1 Signaling Pathway. Biofactors. 2019;45(4):598-606. PubMed PMID: 31336028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway. AU - Yan,Yang, AU - Jun,Chen, AU - Lu,Yang, AU - Jiangmei,Song, Y1 - 2019/07/23/ PY - 2019/04/18/received PY - 2019/05/06/accepted PY - 2019/7/25/pubmed PY - 2020/1/11/medline PY - 2019/7/24/entrez KW - CCl4 KW - HO-1 KW - Nrf2 KW - apoptosis KW - inflammatory cytokines KW - luteolin KW - metformin SP - 598 EP - 606 JF - BioFactors (Oxford, England) JO - Biofactors VL - 45 IS - 4 N2 - Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models of hepatic damage. Metformin (Met) is a potent antidiabetic and redox modulatory agent that has shown anticancer and protective effects on various organs. Therefore, addition of therapy with natural antioxidative agents or herbal extracts shows defensive impacts against different injuries inside the body. Luteolin (Lut) can be found in several customary Chinese remedies. It has been reported for various pharmacological actions such as antitumor, antioxidative, and anti-inflammatory impacts. Here, the liver injury rat model was established using CCl4 (1.00 mL/kg body weight) in vivo. The protective roles of Met and Lut separately or in combination were observed in hepatotoxicity induced by CCl4 . The result was shown that both Met and Lut, while individually used, were normally active in diminishing CCl4 -caused hepatotoxicity. The combination of two drugs performed synergistically to improve liver damage caused by CCl4 , as shown by the considerably improved liver dysfunction. Met and Lut showed highly antioxidative effects on CCl4 -treated rats moderately by increasing the activities and expression of the antioxidant enzymes. Along with this, a combination of Met and Lut significantly suppressed inflammatory responses, which is evidenced by the reduced level of inflammatory cytokines together with interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL-6). Additionally, CCl4 -agitated apoptosis was intensely reduced by Met and Lut through reducing cleaved caspase-3 and Bax (pro-apoptotic factor) while increasing Bcl-2 (antiapoptotic factor) signaling pathways. Cotreatments of Met and Lut upregulated nuclear factor erythroid 2-related factor 2 (NRF2) and heme oxygenase-1 (HO-1) expression in the CCl4 -intoxicated rat's liver. The above result recommended that combination of Met and Lut may have a substantial potential and synergizing impact against CCl4 -induced hepatotoxicity. SN - 1872-8081 UR - https://www.unboundmedicine.com/medline/citation/31336028/Combination_of_metformin_and_luteolin_synergistically_protects_carbon_tetrachloride_induced_hepatotoxicity:_Mechanism_involves_antioxidant_anti_inflammatory_antiapoptotic_and_Nrf2/HO_1_signaling_pathway_ L2 - https://doi.org/10.1002/biof.1521 DB - PRIME DP - Unbound Medicine ER -