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Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody.
Neuropediatrics. 2019 10; 50(5):273-279.N

Abstract

Acute disseminated encephalomyelitis (ADEM) is a common yet clinically heterogenous syndrome characterized by encephalopathy, focal neurologic findings, and abnormal neuroimaging. Differentiating ADEM from other demyelinating disorders of childhood can be difficult and appropriate interpretation of the historical, clinical, and neurodiagnostic components of a patient's presentation is critical. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are a recently recognized set of disorders, which include ADEM presentations, among other phenotypes. This review article discusses the clinical diagnosis, differential diagnosis, interpretation of data, and treatment/prognosis of this unique syndrome with distinctive review of the spectrum of MOG antibodies.

Authors+Show Affiliations

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States. Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States. Department of Neurology, Children's Hospital of Los Angeles, Los Angeles, California, United States. Keck School of Medicine, University of Southern California, Los Angeles, California, United States.Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, United States. Department of Neurology, Harvard Medical School, Boston, Massachusetts, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31340401

Citation

Santoro, Jonathan D., and Tanuja Chitnis. "Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface With MOG Antibody." Neuropediatrics, vol. 50, no. 5, 2019, pp. 273-279.
Santoro JD, Chitnis T. Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. Neuropediatrics. 2019;50(5):273-279.
Santoro, J. D., & Chitnis, T. (2019). Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. Neuropediatrics, 50(5), 273-279. https://doi.org/10.1055/s-0039-1693152
Santoro JD, Chitnis T. Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface With MOG Antibody. Neuropediatrics. 2019;50(5):273-279. PubMed PMID: 31340401.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic Considerations in Acute Disseminated Encephalomyelitis and the Interface with MOG Antibody. AU - Santoro,Jonathan D, AU - Chitnis,Tanuja, Y1 - 2019/07/24/ PY - 2019/7/25/pubmed PY - 2020/6/10/medline PY - 2019/7/25/entrez SP - 273 EP - 279 JF - Neuropediatrics JO - Neuropediatrics VL - 50 IS - 5 N2 - Acute disseminated encephalomyelitis (ADEM) is a common yet clinically heterogenous syndrome characterized by encephalopathy, focal neurologic findings, and abnormal neuroimaging. Differentiating ADEM from other demyelinating disorders of childhood can be difficult and appropriate interpretation of the historical, clinical, and neurodiagnostic components of a patient's presentation is critical. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated diseases are a recently recognized set of disorders, which include ADEM presentations, among other phenotypes. This review article discusses the clinical diagnosis, differential diagnosis, interpretation of data, and treatment/prognosis of this unique syndrome with distinctive review of the spectrum of MOG antibodies. SN - 1439-1899 UR - https://www.unboundmedicine.com/medline/citation/31340401/Diagnostic_Considerations_in_Acute_Disseminated_Encephalomyelitis_and_the_Interface_with_MOG_Antibody_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0039-1693152 DB - PRIME DP - Unbound Medicine ER -