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Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy.
J Biomed Phys Eng 2019; 9(3):267-278JB

Abstract

Purpose

In the current study, using different radiobiological models, tumor control probability (TCP) and normal tissue complication probability (NTCP) of radiotherapy plans were calculated for three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) of prostate cancer.

Methods and Materials

10 prostate plans were randomly selected among patients undergoing radiation therapy of prostate cancer. For each patient, 3D-CRT and IMRT plans were designed to deliver, on average 76 Gy and 82 Gy to planning target volume, respectively. Using different radiobiological models including Poisson, equivalent uniform dose (EUD) and Lyman-Kutcher-Burman (LKB), TCP and NTCP were calculated for prostate and critical organs including bladder, rectum and femoral heads.

Results

IMRT plans provided significantly lower NTCP for bladder, rectum and femoral heads using LKB and EUD models (p-value <0.05). The EUD-calculated TCP for prostate cancer revealed no considerable improvement for IMRT plans relative to 3D-CRT plans. However, the TCPs calculated by Poisson model were dependent on α/β, and higher TCP for IMRT relative to 3D-CRT was seen for α/β higher than 5.

Conclusion

It can be concluded that IMRT plans were superior to 3D-CRT plans in terms of estimated NTCP for studied critical organs. On the other hand, different mathematical models provided different quantitative outcome for TCP of prostate cancer plans. More clinical studies are suggested to confirm the accuracy of studied radiobiological models.

Authors+Show Affiliations

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran. Radiation Oncology Department, Imam Hospital, Tabriz, Iran.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Medical Physics Department, Medical School, Tabriz University of Medical Sciences, Tabriz, Iran.Radiation Oncology Department, Imam Hospital, Tabriz, Iran.Radiation Oncology Department, Imam Hospital, Tabriz, Iran. Radiation Oncology Department, Tabriz International Hospital, Tabriz, Iran.Vocational School of Health Services, Üsküdar University, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31341872

Citation

A, Mesbahi, et al. "Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal Versus Intensity Modulated Radiation Therapy." Journal of Biomedical Physics & Engineering, vol. 9, no. 3, 2019, pp. 267-278.
A M, N R, M M, et al. Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy. J Biomed Phys Eng. 2019;9(3):267-278.
A, M., N, R., M, M., B, N. M., & H, O. T. (2019). Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy. Journal of Biomedical Physics & Engineering, 9(3), pp. 267-278. doi:10.31661/jbpe.v9i3Jun.655.
A M, et al. Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal Versus Intensity Modulated Radiation Therapy. J Biomed Phys Eng. 2019;9(3):267-278. PubMed PMID: 31341872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Radiobiological Models for Radiation Therapy Plans of Prostate Cancer: Three-dimensional Conformal versus Intensity Modulated Radiation Therapy. AU - A,Mesbahi, AU - N,Rasouli, AU - M,Mohammadzadeh, AU - B,Nasiri Motlagh, AU - H,Ozan Tekin, Y1 - 2019/06/01/ PY - 2016/09/24/received PY - 2016/12/08/accepted PY - 2019/7/26/entrez PY - 2019/7/26/pubmed PY - 2019/7/26/medline KW - 3D-CRT, Radiation Therapy KW - IMRT KW - Normal Tissue Complication Probability KW - Prostate Cancer KW - Radiobiological Modelling KW - Tumor Control Probability SP - 267 EP - 278 JF - Journal of biomedical physics & engineering JO - J Biomed Phys Eng VL - 9 IS - 3 N2 - Purpose: In the current study, using different radiobiological models, tumor control probability (TCP) and normal tissue complication probability (NTCP) of radiotherapy plans were calculated for three-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) of prostate cancer. Methods and Materials: 10 prostate plans were randomly selected among patients undergoing radiation therapy of prostate cancer. For each patient, 3D-CRT and IMRT plans were designed to deliver, on average 76 Gy and 82 Gy to planning target volume, respectively. Using different radiobiological models including Poisson, equivalent uniform dose (EUD) and Lyman-Kutcher-Burman (LKB), TCP and NTCP were calculated for prostate and critical organs including bladder, rectum and femoral heads. Results: IMRT plans provided significantly lower NTCP for bladder, rectum and femoral heads using LKB and EUD models (p-value <0.05). The EUD-calculated TCP for prostate cancer revealed no considerable improvement for IMRT plans relative to 3D-CRT plans. However, the TCPs calculated by Poisson model were dependent on α/β, and higher TCP for IMRT relative to 3D-CRT was seen for α/β higher than 5. Conclusion: It can be concluded that IMRT plans were superior to 3D-CRT plans in terms of estimated NTCP for studied critical organs. On the other hand, different mathematical models provided different quantitative outcome for TCP of prostate cancer plans. More clinical studies are suggested to confirm the accuracy of studied radiobiological models. SN - 2251-7200 UR - https://www.unboundmedicine.com/medline/citation/31341872/Comparison_of_Radiobiological_Models_for_Radiation_Therapy_Plans_of_Prostate_Cancer:_Three-dimensional_Conformal_versus_Intensity_Modulated_Radiation_Therapy L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31341872/ DB - PRIME DP - Unbound Medicine ER -