Tags

Type your tag names separated by a space and hit enter

Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.
Toxicol Mech Methods. 2019 Nov; 29(9):644-653.TM

Abstract

The present study investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w.) diabetic rats at different dosages of (25, 50, 100 mg/kg b.w.) respectively for 30 days to evaluate its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin, and carbohydrate metabolic enzymes. The plasma glucose levels were significantly reduced in a dose-dependent manner in hesperdin-treated group of rats when compared to the diabetic control rats. In addition, concomitant increase in hemoglobin and insulin levels and a decrease in glycosylated hemoglobin were observed in treated group of rats. The activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased, whereas glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, hesperidin administration prevented the loss in body weight and improved the glycogen content in the hepatic tissue of diabetic animals by reinstating the activities of glycogen synthase and glycogen phosphorylase. These results showed that hesperidin has potential antihyperglycemic activity in streptozotocin-induced diabetic rats. This was further supported by the histological studies of pancreas and liver.

Authors+Show Affiliations

Meenakshi Academy of Higher Education and Research, Central Research Laboratory, Meenakshi Ammal Dental College , Chennai , India. Department of Biochemistry, Saveetha Dental College & Hospital, Saveetha Institute of Medical & Technical Sciences, Saveetha University , Chennai , India.Department of Biochemistry, Sri Muthukumaran Medical College Hospital and Research Institute , Chennai , India.Department of Pathology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras , Taramani Campus , Chennai , India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31345080

Citation

Sundaram, R, et al. "Hesperidin, a Citrus Flavonoid Ameliorates Hyperglycemia By Regulating Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats." Toxicology Mechanisms and Methods, vol. 29, no. 9, 2019, pp. 644-653.
Sundaram R, Nandhakumar E, Haseena Banu H. Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Toxicol Mech Methods. 2019;29(9):644-653.
Sundaram, R., Nandhakumar, E., & Haseena Banu, H. (2019). Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. Toxicology Mechanisms and Methods, 29(9), 644-653. https://doi.org/10.1080/15376516.2019.1646370
Sundaram R, Nandhakumar E, Haseena Banu H. Hesperidin, a Citrus Flavonoid Ameliorates Hyperglycemia By Regulating Key Enzymes of Carbohydrate Metabolism in Streptozotocin-induced Diabetic Rats. Toxicol Mech Methods. 2019;29(9):644-653. PubMed PMID: 31345080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hesperidin, a citrus flavonoid ameliorates hyperglycemia by regulating key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats. AU - Sundaram,R, AU - Nandhakumar,E, AU - Haseena Banu,H, Y1 - 2019/08/14/ PY - 2019/7/28/pubmed PY - 2020/2/11/medline PY - 2019/7/27/entrez KW - Diabetes KW - carbohydrate metabolic enzymes KW - glycogen KW - hesperidin KW - streptozotocin SP - 644 EP - 653 JF - Toxicology mechanisms and methods JO - Toxicol Mech Methods VL - 29 IS - 9 N2 - The present study investigated the protective effect of hesperidin on carbohydrate metabolizing enzymes in streptozotocin-induced diabetic rats. Hesperidin was administered to streptozotocin-induced (40 mg/kg b.w.) diabetic rats at different dosages of (25, 50, 100 mg/kg b.w.) respectively for 30 days to evaluate its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin, and carbohydrate metabolic enzymes. The plasma glucose levels were significantly reduced in a dose-dependent manner in hesperdin-treated group of rats when compared to the diabetic control rats. In addition, concomitant increase in hemoglobin and insulin levels and a decrease in glycosylated hemoglobin were observed in treated group of rats. The activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased, whereas glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, hesperidin administration prevented the loss in body weight and improved the glycogen content in the hepatic tissue of diabetic animals by reinstating the activities of glycogen synthase and glycogen phosphorylase. These results showed that hesperidin has potential antihyperglycemic activity in streptozotocin-induced diabetic rats. This was further supported by the histological studies of pancreas and liver. SN - 1537-6524 UR - https://www.unboundmedicine.com/medline/citation/31345080/Hesperidin_a_citrus_flavonoid_ameliorates_hyperglycemia_by_regulating_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/15376516.2019.1646370 DB - PRIME DP - Unbound Medicine ER -