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Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys.
Psychopharmacology (Berl). 2019 Dec; 236(12):3677-3685.P

Abstract

RATIONALE

The availability and abuse of synthetic analogues of cathinone have increased dramatically around the world. Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone [MDPV] and α-pyrrolidinopentiophenone [α-PVP], are cocaine-like inhibitors of monoamine transporters and common constituents of "bath salts" or "flakka" preparations. Studies in rats suggest that MDPV and α-PVP are 3 to 4-fold more effective reinforcers than cocaine; however, comparisons of the relative reinforcing effectiveness of MDPV and α-PVP have not been reported in other species.

OBJECTIVES

Accordingly, in the present study, 4 adult male rhesus monkeys responding under a progressive ratio schedule of reinforcement were used to characterize the reinforcing effects of MDPV and α-PVP and to compare directly these effects with those of cocaine and methamphetamine.

RESULTS

MDPV was the most potent reinforcer, followed by α-PVP, methamphetamine, and cocaine. α-PVP was the most effective reinforcer, followed by MDPV, cocaine, and methamphetamine. In addition to making more responses to obtain MDPV and α-PVP, monkeys also responded for longer periods of time when MDPV or α-PVP was available compared with when either cocaine or methamphetamine was available for infusion.

CONCLUSIONS

These studies confirm recent reports from rodents and provide strong evidence that the synthetic cathinones MDPV and α-PVP are capable of maintaining high levels of responding for prolonged periods of time, and that they function as more effective reinforcers than either cocaine or methamphetamine. The relative strength of these reinforcing effects may account for the high rates of "bath salts" use reported in humans.

Authors+Show Affiliations

Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA. CollinsG@uthscsa.edu. Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center, San Antonio, TX, 78229, USA. CollinsG@uthscsa.edu. South Texas Veterans Health Care System, San Antonio, TX, 78229, USA. CollinsG@uthscsa.edu.Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20850, USA.Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20850, USA.Department of Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, Mail Code 7764, San Antonio, TX, 78229, USA. Addiction Research, Treatment & Training Center of Excellence, University of Texas Health Science Center, San Antonio, TX, 78229, USA. Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, 78229, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31346629

Citation

Collins, Gregory T., et al. "Self-administration of the Synthetic Cathinones 3,4-methylenedioxypyrovalerone (MDPV) and Α-pyrrolidinopentiophenone (α-PVP) in Rhesus Monkeys." Psychopharmacology, vol. 236, no. 12, 2019, pp. 3677-3685.
Collins GT, Sulima A, Rice KC, et al. Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys. Psychopharmacology (Berl). 2019;236(12):3677-3685.
Collins, G. T., Sulima, A., Rice, K. C., & France, C. P. (2019). Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys. Psychopharmacology, 236(12), 3677-3685. https://doi.org/10.1007/s00213-019-05339-4
Collins GT, et al. Self-administration of the Synthetic Cathinones 3,4-methylenedioxypyrovalerone (MDPV) and Α-pyrrolidinopentiophenone (α-PVP) in Rhesus Monkeys. Psychopharmacology (Berl). 2019;236(12):3677-3685. PubMed PMID: 31346629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-administration of the synthetic cathinones 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinopentiophenone (α-PVP) in rhesus monkeys. AU - Collins,Gregory T, AU - Sulima,Agnieszka, AU - Rice,Kenner C, AU - France,Charles P, Y1 - 2019/07/26/ PY - 2019/05/08/received PY - 2019/07/19/accepted PY - 2019/7/28/pubmed PY - 2020/3/4/medline PY - 2019/7/27/entrez KW - Cocaine KW - MDPV KW - Methamphetamine KW - Rhesus monkey KW - Self-administration KW - Synthetic cathinones KW - α-PVP SP - 3677 EP - 3685 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 236 IS - 12 N2 - RATIONALE: The availability and abuse of synthetic analogues of cathinone have increased dramatically around the world. Synthetic cathinones, such as 3,4-methylenedioxypyrovalerone [MDPV] and α-pyrrolidinopentiophenone [α-PVP], are cocaine-like inhibitors of monoamine transporters and common constituents of "bath salts" or "flakka" preparations. Studies in rats suggest that MDPV and α-PVP are 3 to 4-fold more effective reinforcers than cocaine; however, comparisons of the relative reinforcing effectiveness of MDPV and α-PVP have not been reported in other species. OBJECTIVES: Accordingly, in the present study, 4 adult male rhesus monkeys responding under a progressive ratio schedule of reinforcement were used to characterize the reinforcing effects of MDPV and α-PVP and to compare directly these effects with those of cocaine and methamphetamine. RESULTS: MDPV was the most potent reinforcer, followed by α-PVP, methamphetamine, and cocaine. α-PVP was the most effective reinforcer, followed by MDPV, cocaine, and methamphetamine. In addition to making more responses to obtain MDPV and α-PVP, monkeys also responded for longer periods of time when MDPV or α-PVP was available compared with when either cocaine or methamphetamine was available for infusion. CONCLUSIONS: These studies confirm recent reports from rodents and provide strong evidence that the synthetic cathinones MDPV and α-PVP are capable of maintaining high levels of responding for prolonged periods of time, and that they function as more effective reinforcers than either cocaine or methamphetamine. The relative strength of these reinforcing effects may account for the high rates of "bath salts" use reported in humans. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/31346629/Self_administration_of_the_synthetic_cathinones_34_methylenedioxypyrovalerone__MDPV__and_α_pyrrolidinopentiophenone__α_PVP__in_rhesus_monkeys_ L2 - https://dx.doi.org/10.1007/s00213-019-05339-4 DB - PRIME DP - Unbound Medicine ER -