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Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion.
Acta Ophthalmol. 2020 Feb; 98(1):e22-e28.AO

Abstract

PURPOSE

To study the prevalence of resolved paracentral acute middle maculopathy (PAMM) lesions in fellow eyes of patients with unilateral retinal vein occlusion (RVO) and eyes of healthy individuals.

METHODS

This case-control observational study took place in a referral university medical centre. Forty-five (17 males, 28 females, 64.7 ± 10.8 years) patients with branch retinal vein occlusion (BRVO), 21 (17 males, 4 females, 68.8 ± 11.2 years) patients with central retinal vein occlusion (CRVO) and 57 healthy individuals (25 males, 32 females, 67.4 ± 10.5 years) were included. Presence of resolved PAMM lesions was evaluated by reviewing cross-sectional scans of 8-mm optical coherence tomography angiography protocol. Resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexiform layer elevation.

RESULTS

Resolved PAMM lesions were found in 32/45 (71.1%) and 15/21 (71.4%) of BRVO and CRVO patients, respectively. In healthy volunteers, resolved PAMM lesions were found in 11/57 (19.3%) individuals with bilateral involvement in 8 individuals (72.7%). RVO patients demonstrated the presence of resolved PAMM lesions in fellow eye significantly more frequently than healthy individuals (odds ratio (OR) 10.6, p < 0.001, 95% CI 4.5-24.6). OR for the presence of large resolved PAMM lesions in BRVO patients and CRVO patients versus healthy individual was 12.1 (p = 0.02, 95% CI 1.5-100.9) and 22.4 (p = 0.005, 95% CI 2.5-200.6), respectively.

CONCLUSION

Resolved PAMM lesions defined as inner nuclear layer thinning associated with outer plexiform layer elevation are highly prevalent in fellow eyes of patients with unilateral RVO. Resolved PAMM lesions may have an association with RVO.

Authors+Show Affiliations

Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.Department of Ophthalmology, Military Medical Academy, St. Petersburg, Russia.Smt. Kanuri Santhamma Retina Vitreous Centre, L.V. Prasad Eye Institute, Hyderabad, India.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31347293

Citation

Maltsev, Dmitrii S., et al. "Prevalence of Resolved Paracentral Acute Middle Maculopathy Lesions in Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion." Acta Ophthalmologica, vol. 98, no. 1, 2020, pp. e22-e28.
Maltsev DS, Kulikov AN, Burnasheva MA, et al. Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion. Acta Ophthalmol. 2020;98(1):e22-e28.
Maltsev, D. S., Kulikov, A. N., Burnasheva, M. A., & Chhablani, J. (2020). Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion. Acta Ophthalmologica, 98(1), e22-e28. https://doi.org/10.1111/aos.14196
Maltsev DS, et al. Prevalence of Resolved Paracentral Acute Middle Maculopathy Lesions in Fellow Eyes of Patients With Unilateral Retinal Vein Occlusion. Acta Ophthalmol. 2020;98(1):e22-e28. PubMed PMID: 31347293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of resolved paracentral acute middle maculopathy lesions in fellow eyes of patients with unilateral retinal vein occlusion. AU - Maltsev,Dmitrii S, AU - Kulikov,Alexei N, AU - Burnasheva,Maria A, AU - Chhablani,Jay, Y1 - 2019/07/25/ PY - 2019/04/06/received PY - 2019/06/29/accepted PY - 2019/7/28/pubmed PY - 2020/11/20/medline PY - 2019/7/27/entrez KW - branch retinal vein occlusion KW - central retinal vein occlusion KW - deep capillary plexus KW - foveal avascular zone KW - optical coherence tomography angiography KW - paracentral acute middle maculopathy KW - retinal ischaemia SP - e22 EP - e28 JF - Acta ophthalmologica JO - Acta Ophthalmol VL - 98 IS - 1 N2 - PURPOSE: To study the prevalence of resolved paracentral acute middle maculopathy (PAMM) lesions in fellow eyes of patients with unilateral retinal vein occlusion (RVO) and eyes of healthy individuals. METHODS: This case-control observational study took place in a referral university medical centre. Forty-five (17 males, 28 females, 64.7 ± 10.8 years) patients with branch retinal vein occlusion (BRVO), 21 (17 males, 4 females, 68.8 ± 11.2 years) patients with central retinal vein occlusion (CRVO) and 57 healthy individuals (25 males, 32 females, 67.4 ± 10.5 years) were included. Presence of resolved PAMM lesions was evaluated by reviewing cross-sectional scans of 8-mm optical coherence tomography angiography protocol. Resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexiform layer elevation. RESULTS: Resolved PAMM lesions were found in 32/45 (71.1%) and 15/21 (71.4%) of BRVO and CRVO patients, respectively. In healthy volunteers, resolved PAMM lesions were found in 11/57 (19.3%) individuals with bilateral involvement in 8 individuals (72.7%). RVO patients demonstrated the presence of resolved PAMM lesions in fellow eye significantly more frequently than healthy individuals (odds ratio (OR) 10.6, p < 0.001, 95% CI 4.5-24.6). OR for the presence of large resolved PAMM lesions in BRVO patients and CRVO patients versus healthy individual was 12.1 (p = 0.02, 95% CI 1.5-100.9) and 22.4 (p = 0.005, 95% CI 2.5-200.6), respectively. CONCLUSION: Resolved PAMM lesions defined as inner nuclear layer thinning associated with outer plexiform layer elevation are highly prevalent in fellow eyes of patients with unilateral RVO. Resolved PAMM lesions may have an association with RVO. SN - 1755-3768 UR - https://www.unboundmedicine.com/medline/citation/31347293/Prevalence_of_resolved_paracentral_acute_middle_maculopathy_lesions_in_fellow_eyes_of_patients_with_unilateral_retinal_vein_occlusion_ L2 - https://doi.org/10.1111/aos.14196 DB - PRIME DP - Unbound Medicine ER -