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The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection.
Life Sci 2019; 231:116688LS

Abstract

The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells, macrophages, neutrophils, mast cells, eosinophils, T cells and B cells are accumulated into the stomach. The interactions between chemokines and their respective receptors recruit particular types of the leukocytes that ultimately determine the nature of immune response and therefore, have a main influence on the consequence of infection. The suitable production of chemokines especially in the early stages of H. pylori infection shapes appropriate immune responses that contribute to the H. pylori elimination. The unbalanced expression of the chemokines can contribute in the induction of inappropriate responses that result in the tissue damage or malignancy. Thus, chemokines and their receptors may be promising potential targets for designing the therapeutic strategies against various types H. pylori-related gastrointestinal disorders. In this review, a comprehensive explanation regarding the roles played by chemokines in H. pylori-mediated peptic ulcer, gastritis and gastric malignancies was provided while presenting the potential utilization of these chemoattractants as therapeutic elements.

Authors+Show Affiliations

Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Electronic address: Jafarzadeh@kmu.ac.ir.Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Hematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, Iran.Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31348950

Citation

Jafarzadeh, Abdollah, et al. "The Important Role Played By Chemokines Influence the Clinical Outcome of Helicobacter Pylori Infection." Life Sciences, vol. 231, 2019, p. 116688.
Jafarzadeh A, Nemati M, Jafarzadeh S. The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection. Life Sci. 2019;231:116688.
Jafarzadeh, A., Nemati, M., & Jafarzadeh, S. (2019). The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection. Life Sciences, 231, p. 116688. doi:10.1016/j.lfs.2019.116688.
Jafarzadeh A, Nemati M, Jafarzadeh S. The Important Role Played By Chemokines Influence the Clinical Outcome of Helicobacter Pylori Infection. Life Sci. 2019 Aug 15;231:116688. PubMed PMID: 31348950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The important role played by chemokines influence the clinical outcome of Helicobacter pylori infection. AU - Jafarzadeh,Abdollah, AU - Nemati,Maryam, AU - Jafarzadeh,Sara, Y1 - 2019/07/23/ PY - 2019/04/21/received PY - 2019/06/30/revised PY - 2019/07/22/accepted PY - 2019/7/28/pubmed PY - 2019/9/20/medline PY - 2019/7/27/entrez KW - Chemokine receptors KW - Chemokines KW - Helicobacter pylori SP - 116688 EP - 116688 JF - Life sciences JO - Life Sci. VL - 231 N2 - The extended infection with Helicobacter pylori (H. pylori), one of the most frequent infectious agents in humans, may cause gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. During H. pylori infection, different kinds of inflammatory cells such as dendritic cells, macrophages, neutrophils, mast cells, eosinophils, T cells and B cells are accumulated into the stomach. The interactions between chemokines and their respective receptors recruit particular types of the leukocytes that ultimately determine the nature of immune response and therefore, have a main influence on the consequence of infection. The suitable production of chemokines especially in the early stages of H. pylori infection shapes appropriate immune responses that contribute to the H. pylori elimination. The unbalanced expression of the chemokines can contribute in the induction of inappropriate responses that result in the tissue damage or malignancy. Thus, chemokines and their receptors may be promising potential targets for designing the therapeutic strategies against various types H. pylori-related gastrointestinal disorders. In this review, a comprehensive explanation regarding the roles played by chemokines in H. pylori-mediated peptic ulcer, gastritis and gastric malignancies was provided while presenting the potential utilization of these chemoattractants as therapeutic elements. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/31348950/The_important_role_played_by_chemokines_influence_the_clinical_outcome_of_Helicobacter_pylori_infection L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(19)30614-9 DB - PRIME DP - Unbound Medicine ER -