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Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study.
BMC Infect Dis 2019; 19(1):665BI

Abstract

BACKGROUND

Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a vector survey to determine the risk factors for acquisition of scrub typhus.

METHODS

A case control study with a 1:2 case control ratio was conducted over a 2 year period at a tertiary care centre and its surrounding districts in South India. Cases were children < 15 years with confirmed scrub typhus. Controls were age and locality matched community controls without fever. Demographic, environmental and behavioural risk factors were obtained in cases and controls by an interview and an environmental survey. A vector survey was also undertaken in the immediate vicinity of the cases.

RESULTS

Case Control study: 101 cases and 167 controls were analysed. On multivariate analysis, significant association was observed with environmental factors such as the presence of a water body within 100 m of the house (OR 3.56(1.36,9.75); p 0.011), cooking outside the house (OR 5.61 (1.51,23.01); p 0.011), owning pets (OR 3.33(1.16,9.09); p 0.031), and the presence of bushes within 5 m of the house (OR 2.78 (1.11,7.69); p 0.033). Of the behavioural factors, the child going to school by a vehicle (OR 3.12 (2.29,8.37); p 0.006) was associated with an increased risk. Drying clothes on a clothesline showed a trend towards protection from acquiring scrub typhus (OR 0.31 (0.08, 1.08); p 0.077). Vector survey:26 rodents were trapped in as many houses. Trombiculid mites were isolated in 24 houses with 9(34.6%) being able to transmit scrub typhus. 254 trombiculid mites belonging to four species and two genera were collected. Leptotrombidium deliense, (33.5%). Schoengastiella ligula, (11.0%) of the total mite specimens collected. S. ligula always co-existed with L. deliense. The estimated Chigger index for Leptotrombidium deliense and Schoengastiella ligula was 3.27and 1.08 per animal respectively.

CONCLUSIONS

Our study highlights risk factors for scrub typhus, some of which may be modifiable. A clean peri-domestic environment free of vegetation, drying clothes on a clothesline and cooking indoors may decrease the risk of scrub typhus.

Authors+Show Affiliations

Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India. winsleyrose@cmcvellore.ac.in.Department of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India. Present Address: Translational Health Science and Technology Institute, Faridabad, Haryana, India.Department of Pediatrics, Christian Medical College, Vellore, Tamil Nadu, India.Department of Health Research, Vector Control Research Centre, Pondicherry, India.Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.Department of Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.Department of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31349809

Citation

Rose, Winsley, et al. "Risk Factors for Acquisition of Scrub Typhus in Children Admitted to a Tertiary Centre and Its Surrounding Districts in South India: a Case Control Study." BMC Infectious Diseases, vol. 19, no. 1, 2019, p. 665.
Rose W, Kang G, Verghese VP, et al. Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study. BMC Infect Dis. 2019;19(1):665.
Rose, W., Kang, G., Verghese, V. P., Candassamy, S., Samuel, P., Prakash, J. J. A., & Muliyil, J. (2019). Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study. BMC Infectious Diseases, 19(1), p. 665. doi:10.1186/s12879-019-4299-2.
Rose W, et al. Risk Factors for Acquisition of Scrub Typhus in Children Admitted to a Tertiary Centre and Its Surrounding Districts in South India: a Case Control Study. BMC Infect Dis. 2019 Jul 26;19(1):665. PubMed PMID: 31349809.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for acquisition of scrub typhus in children admitted to a tertiary centre and its surrounding districts in South India: a case control study. AU - Rose,Winsley, AU - Kang,Gagandeep, AU - Verghese,Valsan Philip, AU - Candassamy,Sadanandane, AU - Samuel,Prasanna, AU - Prakash,John Jude Antony, AU - Muliyil,Jayaprakash, Y1 - 2019/07/26/ PY - 2018/12/12/received PY - 2019/07/18/accepted PY - 2019/7/28/entrez PY - 2019/7/28/pubmed PY - 2019/10/8/medline KW - Children KW - Mites KW - Risk factors KW - Scrub typhus SP - 665 EP - 665 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 19 IS - 1 N2 - BACKGROUND: Scrub typhus is a mite borne zoonosis common in the tropics with no good preventive strategy. Children are also affected leading to considerable morbidity and mortality. We conducted a case control study and a vector survey to determine the risk factors for acquisition of scrub typhus. METHODS: A case control study with a 1:2 case control ratio was conducted over a 2 year period at a tertiary care centre and its surrounding districts in South India. Cases were children < 15 years with confirmed scrub typhus. Controls were age and locality matched community controls without fever. Demographic, environmental and behavioural risk factors were obtained in cases and controls by an interview and an environmental survey. A vector survey was also undertaken in the immediate vicinity of the cases. RESULTS: Case Control study: 101 cases and 167 controls were analysed. On multivariate analysis, significant association was observed with environmental factors such as the presence of a water body within 100 m of the house (OR 3.56(1.36,9.75); p 0.011), cooking outside the house (OR 5.61 (1.51,23.01); p 0.011), owning pets (OR 3.33(1.16,9.09); p 0.031), and the presence of bushes within 5 m of the house (OR 2.78 (1.11,7.69); p 0.033). Of the behavioural factors, the child going to school by a vehicle (OR 3.12 (2.29,8.37); p 0.006) was associated with an increased risk. Drying clothes on a clothesline showed a trend towards protection from acquiring scrub typhus (OR 0.31 (0.08, 1.08); p 0.077). Vector survey:26 rodents were trapped in as many houses. Trombiculid mites were isolated in 24 houses with 9(34.6%) being able to transmit scrub typhus. 254 trombiculid mites belonging to four species and two genera were collected. Leptotrombidium deliense, (33.5%). Schoengastiella ligula, (11.0%) of the total mite specimens collected. S. ligula always co-existed with L. deliense. The estimated Chigger index for Leptotrombidium deliense and Schoengastiella ligula was 3.27and 1.08 per animal respectively. CONCLUSIONS: Our study highlights risk factors for scrub typhus, some of which may be modifiable. A clean peri-domestic environment free of vegetation, drying clothes on a clothesline and cooking indoors may decrease the risk of scrub typhus. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/31349809/Risk_factors_for_acquisition_of_scrub_typhus_in_children_admitted_to_a_tertiary_centre_and_its_surrounding_districts_in_South_India:_a_case_control_study L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-019-4299-2 DB - PRIME DP - Unbound Medicine ER -