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Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial.
Asian Pac J Cancer Prev. 2019 07 01; 20(7):2065-2072.AP

Abstract

Background:

Low levels of vitamin D are found in a great part of breast cancer women. Study subjects using vitamin D3 supplement had lower rates of cancers and fewer markers of inflammation. Additionally, recent studies demonstrate the power of vitamin D supplementation to lower inflammation and oxidative stress biomarkers associate with VDR polymorphism to reduce inflammation. This study was aimed to assess the impact of vitamin D3 supplementation on the serum concentration of inflammatory markers and antioxidant capacity with regard to VDR polymorphism in the VDR gene in breast cancer women.

Methods:

A randomized, double-blind, placebo-controlled trial was conducted on 56 breast cancer women. Participants were assigned to 2 treatment arms: placebo and vitamin D3 for 2 months intervention. Supplementation group received 50,000 IU of vitamin weekly. Blood samples were collected at baseline and after the intervention to measure the 25(OH) D3, TNF-α, TGF- β and TAC. Genotyping was performed for FokI, BsmI, ApaI, and TaqI polymorphism.

Results:

After eight weeks supplementation, the intervention group showed a significant increase in the serum concentration of 25(OH) D3 (28±2.6 to 39±3.5; p=0.004 and TAC (48.9±13.3 to 63.5±13.3; p= 0.017). Changes in TNF-α, TGF- β1 were not significant. Serum TAC levels of participants with the TT/Tt, Ff genotypes were more responsive to supplementation.

Conclusions:

Supplementation with a vitamin D3 increased the TAC in breast cancer women, although it had no effect on inflammatory markers. Serum TAC in the TT/Tt, Ff were more responsive to vitamin D supplement compared with those with the FF/ff and tt genotypes.

Authors+Show Affiliations

Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Diabetes Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Email: amani-r@ajums.ac.ir Food Security Research Center, Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran.Nutrition and Metabolic Disease Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Infectious and Tropical Diseases Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Diabetes Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Email: amani-r@ajums.ac.ir

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31350967

Citation

Mohseni, Houra, et al. "Genetic Variations in VDR Could Modulate the Efficacy of Vitamin D3 Supplementation On Inflammatory Markers and Total Antioxidant Capacity Among Breast Cancer Women: a Randomized Double Blind Controlled Trial." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 20, no. 7, 2019, pp. 2065-2072.
Mohseni H, Amani R, Hosseini SA, et al. Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial. Asian Pac J Cancer Prev. 2019;20(7):2065-2072.
Mohseni, H., Amani, R., Hosseini, S. A., Ekrami, A., Ahmadzadeh, A., & Latifi, S. M. (2019). Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial. Asian Pacific Journal of Cancer Prevention : APJCP, 20(7), 2065-2072. https://doi.org/10.31557/APJCP.2019.20.7.2065
Mohseni H, et al. Genetic Variations in VDR Could Modulate the Efficacy of Vitamin D3 Supplementation On Inflammatory Markers and Total Antioxidant Capacity Among Breast Cancer Women: a Randomized Double Blind Controlled Trial. Asian Pac J Cancer Prev. 2019 07 1;20(7):2065-2072. PubMed PMID: 31350967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic Variations in VDR could Modulate the Efficacy of Vitamin D3 Supplementation on Inflammatory Markers and Total Antioxidant Capacity among Breast Cancer Women: A Randomized Double Blind Controlled Trial. AU - Mohseni,Houra, AU - Amani,Reza, AU - Hosseini,Seyed Ahmad, AU - Ekrami,Alireza, AU - Ahmadzadeh,Ahmad, AU - Latifi,Seyed Mahmoud, Y1 - 2019/07/01/ PY - 2018/10/11/received PY - 2019/7/28/entrez PY - 2019/7/28/pubmed PY - 2020/1/7/medline KW - Inflammation KW - Supplementation KW - VDR polymorphisms KW - Vitamin D3 KW - breast cancer SP - 2065 EP - 2072 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac J Cancer Prev VL - 20 IS - 7 N2 - Background: Low levels of vitamin D are found in a great part of breast cancer women. Study subjects using vitamin D3 supplement had lower rates of cancers and fewer markers of inflammation. Additionally, recent studies demonstrate the power of vitamin D supplementation to lower inflammation and oxidative stress biomarkers associate with VDR polymorphism to reduce inflammation. This study was aimed to assess the impact of vitamin D3 supplementation on the serum concentration of inflammatory markers and antioxidant capacity with regard to VDR polymorphism in the VDR gene in breast cancer women. Methods: A randomized, double-blind, placebo-controlled trial was conducted on 56 breast cancer women. Participants were assigned to 2 treatment arms: placebo and vitamin D3 for 2 months intervention. Supplementation group received 50,000 IU of vitamin weekly. Blood samples were collected at baseline and after the intervention to measure the 25(OH) D3, TNF-α, TGF- β and TAC. Genotyping was performed for FokI, BsmI, ApaI, and TaqI polymorphism. Results: After eight weeks supplementation, the intervention group showed a significant increase in the serum concentration of 25(OH) D3 (28±2.6 to 39±3.5; p=0.004 and TAC (48.9±13.3 to 63.5±13.3; p= 0.017). Changes in TNF-α, TGF- β1 were not significant. Serum TAC levels of participants with the TT/Tt, Ff genotypes were more responsive to supplementation. Conclusions: Supplementation with a vitamin D3 increased the TAC in breast cancer women, although it had no effect on inflammatory markers. Serum TAC in the TT/Tt, Ff were more responsive to vitamin D supplement compared with those with the FF/ff and tt genotypes. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/31350967/Genetic_Variations_in_VDR_could_Modulate_the_Efficacy_of_Vitamin_D3_Supplementation_on_Inflammatory_Markers_and_Total_Antioxidant_Capacity_among_Breast_Cancer_Women:_A_Randomized_Double_Blind_Controlled_Trial_ L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:31350967&key=2019.20.7.2065 DB - PRIME DP - Unbound Medicine ER -