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A case of group infections with Paraginimus species in Henan, Central China.
Acta Trop 2019; :105111AT

Abstract

In July of 2012, mass infections with Paragonimus species were detected in the Henan province sickening 11 of 51 people. In May 2011, these individuals had participated in an excursion during which freshwater crabs were caught and served after being toasted. Before the group infections with Paraginimus species was confirmed, 5 of the 11 patients had been misdiagnosed as tuberculosis (TB) and treated with an anti-TB drug regimen for six months. The most common and typical manifestations were eosinophilia (11/11, 100%) and pulmonary manifestations including, among others, stethalgia and cough (7/11 63.6%). Sero-examination revealed that all 11 patients were seropositive for Paragonimus species. Surprisingly, in our case, one patient presented with hemoptysis and eggs in respiratory secretions, and this is the first time P. skrjabini eggs are detected in the sputum of a patient from the Henan province. Paragonimus metacercariae were collected from 6 of 11 (54.5%) crabs caught at the infection site and were identified as Paraginiumus skrjabini by morphological and molecular examinations. Epidemiological and laboratory evidence confirmed that this is a case of group infection with P. skrjabini. As one of the most neglected tropical diseases (NTD), paragonimiasis should be differentiated diagnosed from TB to avoid the delay of treatment. To our knowledge, this is the second report of a case of group infections with Paraginimus species in Henan, Central China. The first case was reported in 1995. As a kind of food-borne parasitic disease, paragonimiasis should be included in the public health education agenda.

Authors+Show Affiliations

Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Tropical Diseases, National Center for International Research on Tropical Disease, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Tropical Diseases, National Center for International Research on Tropical Disease, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China. Electronic address: chenjx@nipd.chinacdc.cn.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Division of Parasitic Diseases and vectors, Jiyuan Center for Disease Control and Prevention, Jiyuan, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China. Electronic address: bianlixu@163.com.Institute of Parasitic Diseases and vectors, Henan Center for Disease Control and Prevention, Zhengzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31351073

Citation

Chen, Wei-Qi, et al. "A Case of Group Infections With Paraginimus Species in Henan, Central China." Acta Tropica, 2019, p. 105111.
Chen WQ, Deng Y, Zhang YL, et al. A case of group infections with Paraginimus species in Henan, Central China. Acta Trop. 2019.
Chen, W. Q., Deng, Y., Zhang, Y. L., Ai, L., Chen, J. X., Lin, X. M., ... Zhao, Y. L. (2019). A case of group infections with Paraginimus species in Henan, Central China. Acta Tropica, p. 105111. doi:10.1016/j.actatropica.2019.105111.
Chen WQ, et al. A Case of Group Infections With Paraginimus Species in Henan, Central China. Acta Trop. 2019 Jul 24;105111. PubMed PMID: 31351073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case of group infections with Paraginimus species in Henan, Central China. AU - Chen,Wei-Qi, AU - Deng,Yan, AU - Zhang,Ya-Lan, AU - Ai,Lin, AU - Chen,Jia-Xu, AU - Lin,Xi-Meng, AU - Du,Xiao-Bo, AU - Li,Peng, AU - Zhou,Rui-Min, AU - Yang,Cheng-Yun, AU - Liu,Ying, AU - Zhang,Hong-Wei, AU - Xu,Bian-Li, AU - Zhao,Yu-Ling, Y1 - 2019/07/24/ PY - 2019/04/05/received PY - 2019/07/15/revised PY - 2019/07/23/accepted PY - 2019/7/28/entrez PY - 2019/7/28/pubmed PY - 2019/7/28/medline KW - China KW - Henan province KW - Investigation KW - Paragonimiasis SP - 105111 EP - 105111 JF - Acta tropica JO - Acta Trop. N2 - In July of 2012, mass infections with Paragonimus species were detected in the Henan province sickening 11 of 51 people. In May 2011, these individuals had participated in an excursion during which freshwater crabs were caught and served after being toasted. Before the group infections with Paraginimus species was confirmed, 5 of the 11 patients had been misdiagnosed as tuberculosis (TB) and treated with an anti-TB drug regimen for six months. The most common and typical manifestations were eosinophilia (11/11, 100%) and pulmonary manifestations including, among others, stethalgia and cough (7/11 63.6%). Sero-examination revealed that all 11 patients were seropositive for Paragonimus species. Surprisingly, in our case, one patient presented with hemoptysis and eggs in respiratory secretions, and this is the first time P. skrjabini eggs are detected in the sputum of a patient from the Henan province. Paragonimus metacercariae were collected from 6 of 11 (54.5%) crabs caught at the infection site and were identified as Paraginiumus skrjabini by morphological and molecular examinations. Epidemiological and laboratory evidence confirmed that this is a case of group infection with P. skrjabini. As one of the most neglected tropical diseases (NTD), paragonimiasis should be differentiated diagnosed from TB to avoid the delay of treatment. To our knowledge, this is the second report of a case of group infections with Paraginimus species in Henan, Central China. The first case was reported in 1995. As a kind of food-borne parasitic disease, paragonimiasis should be included in the public health education agenda. SN - 1873-6254 UR - https://www.unboundmedicine.com/medline/citation/31351073/A_case_of_group_infections_with_Paraginimus_species_in_Henan,_Central_China L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(19)30449-8 DB - PRIME DP - Unbound Medicine ER -