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Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A.
Infect Immun. 1988 Aug; 56(8):2011-5.II

Abstract

The significance of interferons (IFNs) induced by Listeria monocytogenes in the antilisterial defense mechanism was studied in mice. Cyclosporin A (CsA) had no effect on IFN-alpha production that was induced in the bloodstream after intravenous infection of mice with L. monocytogenes, whereas IFN-gamma that was induced in the bloodstreams of control mice 6 h after stimulation with specific antigen in the late phase of infection was suppressed in CsA-treated mice, depending on the dose of the drug injected. The decrease in IFN-gamma production caused an increase in bacterial growth in the spleens and livers of CsA-treated mice. Furthermore, administration of a daily dose of CsA at 80 or 100 mg/kg of body weight resulted in fatal listeriosis, even though the dose was nonlethal for normal mice. The administration of recombinant murine IFN-gamma on day 0 of L. monocytogenes infection prevented CsA-treated mice from developing fatal listeriosis and restored their ability to produce IFN-gamma in the bloodstream, in response to specific antigen in the late phase of infection.

Authors+Show Affiliations

Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3135267

Citation

Nakane, A, et al. "Prevention By Gamma Interferon of Fatal Infection With Listeria Monocytogenes in Mice Treated With Cyclosporin A." Infection and Immunity, vol. 56, no. 8, 1988, pp. 2011-5.
Nakane A, Minagawa T, Yasuda I, et al. Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A. Infect Immun. 1988;56(8):2011-5.
Nakane, A., Minagawa, T., Yasuda, I., Yu, C., & Kato, K. (1988). Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A. Infection and Immunity, 56(8), 2011-5.
Nakane A, et al. Prevention By Gamma Interferon of Fatal Infection With Listeria Monocytogenes in Mice Treated With Cyclosporin A. Infect Immun. 1988;56(8):2011-5. PubMed PMID: 3135267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention by gamma interferon of fatal infection with Listeria monocytogenes in mice treated with cyclosporin A. AU - Nakane,A, AU - Minagawa,T, AU - Yasuda,I, AU - Yu,C, AU - Kato,K, PY - 1988/8/1/pubmed PY - 1988/8/1/medline PY - 1988/8/1/entrez SP - 2011 EP - 5 JF - Infection and immunity JO - Infect. Immun. VL - 56 IS - 8 N2 - The significance of interferons (IFNs) induced by Listeria monocytogenes in the antilisterial defense mechanism was studied in mice. Cyclosporin A (CsA) had no effect on IFN-alpha production that was induced in the bloodstream after intravenous infection of mice with L. monocytogenes, whereas IFN-gamma that was induced in the bloodstreams of control mice 6 h after stimulation with specific antigen in the late phase of infection was suppressed in CsA-treated mice, depending on the dose of the drug injected. The decrease in IFN-gamma production caused an increase in bacterial growth in the spleens and livers of CsA-treated mice. Furthermore, administration of a daily dose of CsA at 80 or 100 mg/kg of body weight resulted in fatal listeriosis, even though the dose was nonlethal for normal mice. The administration of recombinant murine IFN-gamma on day 0 of L. monocytogenes infection prevented CsA-treated mice from developing fatal listeriosis and restored their ability to produce IFN-gamma in the bloodstream, in response to specific antigen in the late phase of infection. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/3135267/Prevention_by_gamma_interferon_of_fatal_infection_with_Listeria_monocytogenes_in_mice_treated_with_cyclosporin_A_ L2 - http://iai.asm.org/cgi/pmidlookup?view=long&pmid=3135267 DB - PRIME DP - Unbound Medicine ER -