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Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population.
Forensic Sci Int Genet. 2019 Sep; 42:e13-e20.FS

Abstract

Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) frequency distributions provide resources for assessment of male population stratification among world-wide populations. Currently, the Y-STR Haplotype Reference Database (YHRD) contains numerous Y-chromosome haplotype profiles from various populations and countries around the world. However, for many of the recently discovered and already phylogenetically mapped Y-SNPs, the population data are scarce. Herein, the typing of 27 Y-STRs (Yfiler Plus) and 143 Y-SNPs (self-designed Y-SNP panel) was performed on 1269 unrelated males from 11 Han Chinese populations. Haplogroup O-M175 was the most predominant haplogroup in our Han Chinese data, ranging from 67.34% (Henan Han) to 93.16% (Guangdong Han). The highest haplogroup diversity (0.967056) was observed in Heilongjiang Han, with a discrimination capacity (DC) value of 0.3723. The number of alleles at single-copy loci varied from 2 for DYS391 (Guangdong Han) to 16 for DYS518 (Henan Han). For the majority of the populations (8/11), both the haplotype diversity and DC values are 1.0000. Furthermore, genetic differentiations were observed between Northern and Southern Han Chinese. These genetic differences were mainly reflected in haplogroup distribution and frequency, and they were confirmed by statistical analysis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

The Institute of Forensic Science and Technology, Henan Provincial Public Security Bureau, Zhengzhou 450003, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

The Institute of Forensic Science and Technology, Henan Provincial Public Security Bureau, Zhengzhou 450003, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Beijing Police College, Beijing 102202, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Department of Forensic genetics, Brain Hospital of Hunan Province, Hunan University of Chinese Medicine, Changsha 410007, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Criminal Detection Unit of Qingxiu District Public Security Sub-bureau in Nanning, Nanning 530000, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Department of Forensic Science, Zhejiang Police College, Hangzhou 310053, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Forensic Science Institute of Zhejiang Di'an Diagnosis Technology Co., Ltd, Hangzhou 310012, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Forensic Science Center Zhongding Guangdong, Zhanjiang 524000, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Beijing Tongda Shoucheng Institute of Forensic Science, Beijing 100085, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.

Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China. Electronic address: forensic@scu.edu.cn.

MeSH

Asian PeopleChinaChromosomes, Human, YDNA FingerprintingEthnicityGenetics, PopulationHaplotypesHumansMaleMicrosatellite RepeatsPhylogenyPolymorphism, Single Nucleotide

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31353318

Citation

Lang, Min, et al. "Forensic Characteristics and Genetic Analysis of Both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese Population." Forensic Science International. Genetics, vol. 42, 2019, pp. e13-e20.

Lang M, Liu H, Song F, et al. Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population. Forensic Sci Int Genet. 2019;42:e13-e20.

Lang, M., Liu, H., Song, F., Qiao, X., Ye, Y., Ren, H., Li, J., Huang, J., Xie, M., Chen, S., Song, M., Zhang, Y., Qian, X., Yuan, T., Wang, Z., Liu, Y., Wang, M., Liu, Y., Liu, J., & Hou, Y. (2019). Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population. Forensic Science International. Genetics, 42, e13-e20. https://doi.org/10.1016/j.fsigen.2019.07.011

Lang M, et al. Forensic Characteristics and Genetic Analysis of Both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese Population. Forensic Sci Int Genet. 2019;42:e13-e20. PubMed PMID: 31353318.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Forensic characteristics and genetic analysis of both 27 Y-STRs and 143 Y-SNPs in Eastern Han Chinese population. AU - Lang,Min, AU - Liu,Hai, AU - Song,Feng, AU - Qiao,Xianhua, AU - Ye,Yi, AU - Ren,He, AU - Li,Jienan, AU - Huang,Jian, AU - Xie,Mingkun, AU - Chen,Shengjie, AU - Song,Mengyuan, AU - Zhang,Youfang, AU - Qian,Xiaoqin, AU - Yuan,Taoxiu, AU - Wang,Zheng, AU - Liu,Yuming, AU - Wang,Mengge, AU - Liu,Yacheng, AU - Liu,Jing, AU - Hou,Yiping, Y1 - 2019/07/23/ PY - 2019/1/3/received PY - 2019/7/20/revised PY - 2019/7/20/accepted PY - 2019/7/30/pubmed PY - 2019/12/20/medline PY - 2019/7/30/entrez KW - Han Chinese KW - Y-chromosome SNP KW - Y-chromosome STR SP - e13 EP - e20 JF - Forensic science international. Genetics JO - Forensic Sci Int Genet VL - 42 N2 - Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) frequency distributions provide resources for assessment of male population stratification among world-wide populations. Currently, the Y-STR Haplotype Reference Database (YHRD) contains numerous Y-chromosome haplotype profiles from various populations and countries around the world. However, for many of the recently discovered and already phylogenetically mapped Y-SNPs, the population data are scarce. Herein, the typing of 27 Y-STRs (Yfiler Plus) and 143 Y-SNPs (self-designed Y-SNP panel) was performed on 1269 unrelated males from 11 Han Chinese populations. Haplogroup O-M175 was the most predominant haplogroup in our Han Chinese data, ranging from 67.34% (Henan Han) to 93.16% (Guangdong Han). The highest haplogroup diversity (0.967056) was observed in Heilongjiang Han, with a discrimination capacity (DC) value of 0.3723. The number of alleles at single-copy loci varied from 2 for DYS391 (Guangdong Han) to 16 for DYS518 (Henan Han). For the majority of the populations (8/11), both the haplotype diversity and DC values are 1.0000. Furthermore, genetic differentiations were observed between Northern and Southern Han Chinese. These genetic differences were mainly reflected in haplogroup distribution and frequency, and they were confirmed by statistical analysis. SN - 1878-0326 UR - https://www.unboundmedicine.com/medline/citation/31353318/Forensic_characteristics_and_genetic_analysis_of_both_27_Y_STRs_and_143_Y_SNPs_in_Eastern_Han_Chinese_population_ DB - PRIME DP - Unbound Medicine ER -