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J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study.
J Dermatol. 2019 Oct; 46(10):902-906.JD

Abstract

The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education.

Authors+Show Affiliations

Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan. Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan. Institute of General Education, Kyoto Sangyo University, Kyoto, Japan.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan.Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan. Shimane University Faculty of Medicine, Shimane, Japan.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan. Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.Center for Primary Health Care Research, Lund University, Malmö, Sweden.Center for Primary Health Care Research, Lund University, Malmö, Sweden.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan. Center for Primary Health Care Research, Lund University, Malmö, Sweden. Departments of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Center for Community-based Health Research and Education (CoHRE), Organization for Research and Academic Information, Shimane University, Izumo, Japan. Center for Primary Health Care Research, Lund University, Malmö, Sweden. Departments of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.Department of Dermatology, Shimane University Faculty of Medicine, Izumo, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31353631

Citation

Kohno, Kunie, et al. "J-curve Association Between Alcohol Intake and Varicose Veins in Japan: the Shimane CoHRE Study." The Journal of Dermatology, vol. 46, no. 10, 2019, pp. 902-906.
Kohno K, Niihara H, Hamano T, et al. J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study. J Dermatol. 2019;46(10):902-906.
Kohno, K., Niihara, H., Hamano, T., Takeda, M., Nakagawa, Y., Shiwaku, K., Nabika, T., Zöller, B., Li, X., Sundquist, K., Sundquist, J., & Morita, E. (2019). J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study. The Journal of Dermatology, 46(10), 902-906. https://doi.org/10.1111/1346-8138.15022
Kohno K, et al. J-curve Association Between Alcohol Intake and Varicose Veins in Japan: the Shimane CoHRE Study. J Dermatol. 2019;46(10):902-906. PubMed PMID: 31353631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - J-curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study. AU - Kohno,Kunie, AU - Niihara,Hiroyuki, AU - Hamano,Tsuyoshi, AU - Takeda,Miwako, AU - Nakagawa,Yusei, AU - Shiwaku,Kuninori, AU - Nabika,Toru, AU - Zöller,Bengt, AU - Li,Xinjun, AU - Sundquist,Kristina, AU - Sundquist,Jan, AU - Morita,Eishin, Y1 - 2019/07/29/ PY - 2019/01/18/received PY - 2019/07/01/accepted PY - 2019/7/30/pubmed PY - 2019/11/14/medline PY - 2019/7/30/entrez KW - alcohol drinking KW - epidemiology KW - lifestyle KW - varicose veins KW - venous thromboembolism SP - 902 EP - 906 JF - The Journal of dermatology JO - J Dermatol VL - 46 IS - 10 N2 - The effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross-sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle-related factors and medical history, compared with non-drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1-5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J-curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence-based patient education. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/31353631/J_curve_association_between_alcohol_intake_and_varicose_veins_in_Japan:_The_Shimane_CoHRE_Study_ L2 - https://doi.org/10.1111/1346-8138.15022 DB - PRIME DP - Unbound Medicine ER -